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Where hypotheses become headlines: Featured coverage of the breakthroughs—and the people—driving our research forward

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The Scripps Research scientists leading the Huang Foundation-supported projects. From left: Terrence Messmer, Sarah Burbach, Matthew Holcomb, Bryan Briney, Stefano Forli, Benjamin Cravatt, Christopher Parker, Andrew Ward and Charles Bowman.
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Scripps Research garners major support for AI innovations in biomedicine with compute grant from Jen-Hsun and Lori Huang Foundation

Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

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  • From left: K. Barry Sharpless, Ardem Patapoutian and Dr. Herbert Wertheim Credit: Scripps Research
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    Scripps Research Nobel laureates Ardem Patapoutian and K. Barry Sharpless among first honored by new Wertheim Laureate Prize

  • Ron Burkle Credit: Ron Burkle
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    Scripps Research names Ron Burkle chair of its Board of Directors

  • From left: Richard Ulevitch, professor emeritus at Scripps Research, and Rob Garbaccio, senior vice president at Merck. Credit: Scripps Research.
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    Scripps Research bestows inaugural Distinguished Alumni Awards

  • Keren Lasker
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    Scripps Research associate professor Keren Lasker receives DARPA Young Faculty Award to develop “toxin traps”

  • A newly designed transmembrane peptide (blue) binds to the TLR4 (orange) transmembrane helix, blocking receptor dimerization and reducing LPS-driven NF-κB inflammatory signaling. Credit: Scripps Research
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    Computer-designed protein targets immune receptor linked to inflammation at a new “undruggable” site

  • Li Ye, PhD Credit: Scripps Research
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    Scripps Research professor Li Ye named finalist for Blavatnik National Awards for Young Scientists

  • Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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    Scientists discover a new way that a disease-linked protein comes apart

  • Dyna-1 predicted millisecond-scale movements in regions of KRAS (pictured), a cancer-associated protein that has been notoriously difficult to target. “Switch I” and “Switch II” indicate the protein’s movements in this timescale. The thickness of the circular dashed lines indicates Dyna-1’s predictions compared to the experimentally measured us-ms exchange in color.
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    Where milliseconds matter: Scripps Research scientists build new ML model to predict protein movements essential for biological function

  • From left: Michael Ko and Giorgio Quer
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    New AI algorithm could improve detection and prediction of heart diseases

  • Image shows a stabilized CA09 influenza HA trimer, with the 60-mer self-assembling protein nanoparticle (SApNP) HA-E2p-L4P on the left and HA-I3-01v9b-L7P on the right.
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    New design strategy expands nanoparticle vaccine approach to influenza viruses

  • Left to right: Lingran Kong, Brandon Orzolek, Ryan Shenvi and Kevin Zong.
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    Chemists develop simpler method to make molecular building block for drug development

  • Pete Schultz, president and CEO of Scripps Research. Credit: Scripps Research
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    Scripps Research establishes endowed fund honoring institute president and CEO Pete Schultz

    Philanthropy
  • Vial-gripping arm of the Unchained Labs Big Kahuna, the node’s core piece of automation equipment
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    Scripps Research and collaborators awarded $19.5 million to establish an open-access autonomous chemistry laboratory

  • Tiantian Liu
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    Scripps Research scientist to receive $2.76 million NIAID New Innovators Award

  • Greg Tabor
    News

    Paying It Forward: Greg Tabor on Giving Back to the Next Generation

  • New research offers fresh insights for how to make better vaccines
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    New research offers fresh insights for how to make better vaccines

  • peter vogt
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    Scripps Research establishes endowed chair honoring Peter K. Vogt, influential pioneer in cancer research

  • From left, professor Xiang-Lei Yang and postdoctoral associate Huimin Zhang.
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    A double “off-switch” helps cells respond to stress

  • Scripps Research scientists train the immune system to make antibodies against numerous HIV strains
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    Scripps Research scientists train the immune system to make antibodies against numerous HIV strains

  • Joan Pulupa. Credit: Timothy White
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    Joan Pulupa joins Scripps Research faculty to study the organization of DNA in brain cells and its links to neurodegeneration

  • Scripps Research Professor Kristian Andersen (far left), Dylan Pilz (second from left) and Senior Project Scientist Josh Levy (far right) with their NICD colleagues at a recent conference in Accra, Ghana. Credit: Scripps Research
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    Scripps Research scientists awarded $2M to advance global disease surveillance

  • Scripps Research scientists demonstrate a faster, cheaper route to making critical drugs using common table sugar
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    Scripps Research scientists demonstrate a faster, cheaper route to making critical drugs using common table sugar

    New method illustrates how to build a tough chemical bond found in carbohydrate-based drugs, such as those for treating diabetes.

  • New research offers fresh insights for how to make better vaccines
    News

    Back in action: Researchers make drug-resistant bacteria vulnerable again

    New findings from Scripps Research show that disabling a single bacterial protein can restore vancomycin’s power against resistant bacteria–and point to a new strategy for overcoming antibiotic resistance.

  • Immune molecule may drive excessive drinking in alcohol use disorder
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    Immune molecule may drive excessive drinking in alcohol use disorder

    Scripps Research scientists showed that blocking an immune molecule tied to inflammation reduced alcohol consumption in mice.

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