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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award
Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart
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  • Dyna-1 predicted millisecond-scale movements in regions of KRAS (pictured), a cancer-associated protein that has been notoriously difficult to target. “Switch I” and “Switch II” indicate the protein’s movements in this timescale. The thickness of the circular dashed lines indicates Dyna-1’s predictions compared to the experimentally measured us-ms exchange in color.
    News

    Where milliseconds matter: Scripps Research scientists build new ML model to predict protein movements essential for biological function

    Integrative Structural & Computational Biology
  • From left: Michael Ko and Giorgio Quer
    News

    New AI algorithm could improve detection and prediction of heart diseases

    Translational Medicine Integrative Structural & Computational Biology
  • Image shows a stabilized CA09 influenza HA trimer, with the 60-mer self-assembling protein nanoparticle (SApNP) HA-E2p-L4P on the left and HA-I3-01v9b-L7P on the right.
    News

    New design strategy expands nanoparticle vaccine approach to influenza viruses

    Integrative Structural & Computational Biology
  • Left to right: Lingran Kong, Brandon Orzolek, Ryan Shenvi and Kevin Zong.
    News

    Chemists develop simpler method to make molecular building block for drug development

    Chemistry
  • Pete Schultz, president and CEO of Scripps Research. Credit: Scripps Research
    News

    Scripps Research establishes endowed fund honoring institute president and CEO Pete Schultz

    Philanthropy
  • Vial-gripping arm of the Unchained Labs Big Kahuna, the node’s core piece of automation equipment
    News

    Scripps Research and collaborators awarded $19.5 million to establish an open-access autonomous chemistry laboratory

    Chemistry
  • Jeff Kelly
    News

    Scripps Research professor Jeffery Kelly elected to the European Academy of Engineering

    Chemistry
  • Tiantian Liu
    News

    Scripps Research scientist to receive $2.76 million NIAID New Innovators Award

    Immunology & Microbiology
  • Greg Tabor
    News

    Paying It Forward: Greg Tabor on Giving Back to the Next Generation

    Chemistry
  • New research offers fresh insights for how to make better vaccines
    News

    New research offers fresh insights for how to make better vaccines

    Immunology & Microbiology
  • peter vogt
    News

    Scripps Research establishes endowed chair honoring Peter K. Vogt, influential pioneer in cancer research

    Molecular & Cellular Biology
  • From left, professor Xiang-Lei Yang and postdoctoral associate Huimin Zhang.
    News

    A double “off-switch” helps cells respond to stress

    Integrative Structural & Computational Biology
  • Scripps Research scientists train the immune system to make antibodies against numerous HIV strains
    News

    Scripps Research scientists train the immune system to make antibodies against numerous HIV strains

    Immunology & Microbiology
  • Joan Pulupa. Credit: Timothy White
    News

    Joan Pulupa joins Scripps Research faculty to study the organization of DNA in brain cells and its links to neurodegeneration

    Molecular & Cellular Biology
  • Scripps Research Professor Kristian Andersen (far left), Dylan Pilz (second from left) and Senior Project Scientist Josh Levy (far right) with their NICD colleagues at a recent conference in Accra, Ghana. Credit: Scripps Research
    News

    Scripps Research scientists awarded $2M to advance global disease surveillance

    Translational Medicine
  • Scripps Research scientists demonstrate a faster, cheaper route to making critical drugs using common table sugar
    News

    Scripps Research scientists demonstrate a faster, cheaper route to making critical drugs using common table sugar

    New method illustrates how to build a tough chemical bond found in carbohydrate-based drugs, such as those for treating diabetes.

    Chemistry
  • New research offers fresh insights for how to make better vaccines
    News

    Back in action: Researchers make drug-resistant bacteria vulnerable again

    New findings from Scripps Research show that disabling a single bacterial protein can restore vancomycin’s power against resistant bacteria–and point to a new strategy for overcoming antibiotic resistance.

    Immunology & Microbiology
  • Immune molecule may drive excessive drinking in alcohol use disorder
    News

    Immune molecule may drive excessive drinking in alcohol use disorder

    Scripps Research scientists showed that blocking an immune molecule tied to inflammation reduced alcohol consumption in mice.

    Translational Medicine
  • Molecular scissors caught in action: A structural blueprint for RNA therapeutics
    News

    Molecular scissors caught in action: A structural blueprint for RNA therapeutics

    A Scripps Research team has captured the first high-resolution structural images of human Argonaute 2 in its cutting-ready state, revealing why some small interfering RNA (siRNA) molecules work better than others and how to design more effective ones for this emerging therapy.

    Integrative Structural & Computational Biology
  • Newly identified molecule strengthens the eye’s response to damage in retinal disease
    News

    Newly identified molecule strengthens the eye’s response to damage in retinal disease

    Scripps Research discovery finds that restoring the naturally occurring compound erucamide in the eye stabilized tissue in preclinical models of retinal degeneration.

    Neuroscience
  • Lab studies explain how new cancer drug works as it enters patient testing
    News

    Lab studies explain how new cancer drug works as it enters patient testing

    Immunologists at Scripps Research show how a new, experimental drug revives immune cells to fight cancer.
  • Calibr-Skaggs awarded $5.1M by NIH to develop long-acting hepatitis B virus therapy
    News

    Calibr-Skaggs awarded $5.1M by NIH to develop long-acting hepatitis B virus therapy

    A new program aims to replace a daily HBV drug with once-monthly—or even quarterly—injections for people managing both HIV and HBV.

    Chemistry Calibr-Skaggs
  • Two Scripps Research assistant professors named 2026 Baxter Young Investigators
    News

    Two Scripps Research assistant professors named 2026 Baxter Young Investigators

    The Baxter Foundation annually support early-career researchers whose work in science and technology holds promise for improving patient care.

    Chemistry Molecular & Cellular Biology
  • A fentanyl countermeasure that adapts to combat future black-market drugs
    News

    A fentanyl countermeasure that adapts to combat future black-market drugs

    Scripps Research scientists developed a vaccine that teaches the immune system to rapidly neutralize fentanyl and new emerging synthetic fentanyl analogs.

    Chemistry
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