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Scripps Research scientists train the immune system to make antibodies against numerous HIV strains
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Scripps Research scientists train the immune system to make antibodies against numerous HIV strains

Joan Pulupa. Credit: Timothy White
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Joan Pulupa joins Scripps Research faculty to study the organization of DNA in brain cells and its links to neurodegeneration

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  • New technique for synthesizing branched molecules could accelerate the development of future medicines
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    New technique for synthesizing branched molecules could accelerate the development of future medicines

    Scripps Research chemists solve a longstanding problem in the construction of branched molecular frameworks, unlocking a faster path to the complex structures found in drugs and materials.

  • Scripps Research’s Skaggs Graduate School ranked #1 in Biological Sciences by U.S. News & World Report
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    Scripps Research’s Skaggs Graduate School ranked #1 in Biological Sciences by U.S. News & World Report

    The doctoral program also placed #7 in Chemistry in the publication’s latest issue ranking top science graduate schools.

  • Scripps Research scientists uncover new mechanism cancer cells use to survive DNA damage
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    Scripps Research scientists uncover new mechanism cancer cells use to survive DNA damage

    Discovery reshapes understanding of how tumor cells repair broken DNA, pointing toward more precise cancer therapies.

  • Study shows new drug compounds dial down inflammation without compromising immunity
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    Study shows new drug compounds dial down inflammation without compromising immunity

    First-in-class molecules block a specific protein interaction in immune cells, offering a potential targeted approach to autoimmune diseases like lupus and rheumatoid arthritis.

  • Scripps Research scientists awarded nearly $5 million by NIH to investigate cancer growth
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    Scripps Research scientists awarded nearly $5 million by NIH to investigate cancer growth

    Researchers will investigate how a common dietary nutrient may control a hidden layer of gene regulation in cancer cells.

  • Scientists pinpoint protein shapes that track Alzheimer’s progression
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    Scientists pinpoint protein shapes that track Alzheimer’s progression

    New findings from Scripps Research show that changes in protein shape—rather than quantity of proteins—offer a potential new way to detect and track Alzheimer’s disease.

  • A new clue to how the body detects physical force
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    A new clue to how the body detects physical force

    Scripps Research scientists offer new insight into how the body detects light touch and how disruptions in that process may contribute to sensory disorders.

  • Nanoparticle vaccine approach takes on a new target: Hepatitis C virus
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    Nanoparticle vaccine approach takes on a new target: Hepatitis C virus

    Scripps Research scientists reengineer critical proteins on the surface of HCV, paving the way for a new vaccine design.

  • Scripps Research welcomes healthcare innovator Joe Kiani to the Board of Directors
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    Scripps Research welcomes healthcare innovator Joe Kiani to the Board of Directors

    Kiani brings decades of experience in patient safety and public service.

  • New way to intentionally discover molecular glues could expand drug discovery
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    New way to intentionally discover molecular glues could expand drug discovery

    Scripps Research scientists and colleagues show how drugs that eliminate certain disease-driving proteins can be discovered systematically rather than by chance.

  • Hidden architecture inside cellular droplets reveals new targets for cancer and neurodegeneration
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    Hidden architecture inside cellular droplets reveals new targets for cancer and neurodegeneration

    Scripps Research scientists discover that some membrane-less compartments are built from tiny filaments—a finding that could shape drug development.

  • Mapping protein production in brain cells yields new insights for brain disease
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    Mapping protein production in brain cells yields new insights for brain disease

    Scripps Research and UC San Diego scientists used a novel method to show that some memory neurons produce proteins at higher rates than others.

  • Calibr-Skaggs and Kainomyx launch collaboration to pioneer novel malaria treatments
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    Calibr-Skaggs and Kainomyx launch collaboration to pioneer novel malaria treatments

    Partnering to speed up the discovery of new malaria drugs that target parasite cytoskeletal pathways, with a focus on global access and affordability.

  • TIME100 Health list features Scripps Research Professor Darrell Irvine
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    TIME100 Health list features Scripps Research Professor Darrell Irvine

    Irvine is recognized for his work in empowering the immune system to fight disease, which includes enhancing vaccines against HIV and cancer. 

  • Fentanyl makeover: Core structural redesign could lead to safer pain medications
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    Fentanyl makeover: Core structural redesign could lead to safer pain medications

    Modified molecule shows diminished respiratory depression—the leading cause of opioid overdose deaths—while retaining full pain-blocking capability.

  • How “invisible” vaccine scaffolding boosts HIV immune response
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    How “invisible” vaccine scaffolding boosts HIV immune response

    Scripps Research scientists designed a DNA scaffold that carries HIV vaccine proteins into the body and sharpens the immune response against the virus.

  • Scientists measure cellular membrane thickness inside cells for the first time
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    Scientists measure cellular membrane thickness inside cells for the first time

    Measuring membrane thickness was previously only possible in artificial membranes—now scientists can do it inside intact cells, providing crucial context for understanding how cells work.

  • Scripps Research study links sleep variability with sleep apnea and hypertension
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    Scripps Research study links sleep variability with sleep apnea and hypertension

    How consumers’ digital activity trackers could enable personalized health screening and early intervention for cardiovascular health and beyond.

  • Study uncovers disrupted brain balance in alcohol dependence
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    Study uncovers disrupted brain balance in alcohol dependence

    Experiments show how dependence on alcohol rewires the brain's "go" and "stop drinking" signaling systems, with implications for preventing relapse.

  • New technique lights up where drugs go in the body, cell by cell
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    New technique lights up where drugs go in the body, cell by cell

    Scripps Research scientists developed a technique that maps drug binding in individual cells throughout the body, potentially explaining side effects and guiding safer drug development.

  • A jolt to the system: Scripps Research biophysicists uncover new electrical transmission in cells
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    A jolt to the system: Scripps Research biophysicists uncover new electrical transmission in cells

    “Tiny biological batteries” can change the cell membrane’s electrical properties—a discovery that has big implications for health, as many essential cellular processes hinge upon precise electrical activity.

  • Study reveals a key hormonal circuit in the kidneys
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    Study reveals a key hormonal circuit in the kidneys

    Scripps Research scientists identify the protein that helps kidney cells regulate renin, providing foundational insight into how kidneys function.

  • Nanoparticle vaccine strategy could protect against Ebola and other deadly filoviruses
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    Nanoparticle vaccine strategy could protect against Ebola and other deadly filoviruses

    Scripps Research scientists turn nanoparticles into virus “showcases” to help the immune system recognize deadly threats.

  • Study reveals high stakes of early immune development—and a potential probiotic fix
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    Study reveals high stakes of early immune development—and a potential probiotic fix

    Scripps Research scientists find that certain gut bacteria are essential for building immune defenses during infancy, pointing to new strategies for protecting children’s health.

Groundbreaking Science.
Life-changing Medicine.