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Where hypotheses become headlines: Featured coverage of the breakthroughs—and the people—driving our research forward

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The Scripps Research scientists leading the Huang Foundation-supported projects. From left: Terrence Messmer, Sarah Burbach, Matthew Holcomb, Bryan Briney, Stefano Forli, Benjamin Cravatt, Christopher Parker, Andrew Ward and Charles Bowman.
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Scripps Research garners major support for AI innovations in biomedicine with compute grant from Jen-Hsun and Lori Huang Foundation

Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

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  • Molecular scissors caught in action: A structural blueprint for RNA therapeutics
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    Molecular scissors caught in action: A structural blueprint for RNA therapeutics

    A Scripps Research team has captured the first high-resolution structural images of human Argonaute 2 in its cutting-ready state, revealing why some small interfering RNA (siRNA) molecules work better than others and how to design more effective ones for this emerging therapy.

  • Newly identified molecule strengthens the eye’s response to damage in retinal disease
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    Newly identified molecule strengthens the eye’s response to damage in retinal disease

    Scripps Research discovery finds that restoring the naturally occurring compound erucamide in the eye stabilized tissue in preclinical models of retinal degeneration.

  • Lab studies explain how new cancer drug works as it enters patient testing
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    Lab studies explain how new cancer drug works as it enters patient testing

    Immunologists at Scripps Research show how a new, experimental drug revives immune cells to fight cancer.

  • Calibr-Skaggs awarded $5.1M by NIH to develop long-acting hepatitis B virus therapy
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    Calibr-Skaggs awarded $5.1M by NIH to develop long-acting hepatitis B virus therapy

    A new program aims to replace a daily HBV drug with once-monthly—or even quarterly—injections for people managing both HIV and HBV.

  • Two Scripps Research assistant professors named 2026 Baxter Young Investigators
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    Two Scripps Research assistant professors named 2026 Baxter Young Investigators

    The Baxter Foundation annually support early-career researchers whose work in science and technology holds promise for improving patient care.

  • A fentanyl countermeasure that adapts to combat future black-market drugs
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    A fentanyl countermeasure that adapts to combat future black-market drugs

    Scripps Research scientists developed a vaccine that teaches the immune system to rapidly neutralize fentanyl and new emerging synthetic fentanyl analogs.

  • Chemists snap together complex 3D molecules from highly reactive ‘radicals’—without losing their shape
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    Chemists snap together complex 3D molecules from highly reactive ‘radicals’—without losing their shape

    Scripps Research team develops stereoretentive radical-radical cross-coupling, a simpler way to build chiral drug candidates.

  • Calibr-Skaggs advances CLF065, a regenerative GLP-2 therapy, into two Phase 2 IBD studies
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    Calibr-Skaggs advances CLF065, a regenerative GLP-2 therapy, into two Phase 2 IBD studies

    CLF065, a long-acting, once-weekly GLP-2 receptor agonist, advances in two inflammatory bowel disease indications. The studies aim to bring a regenerative treatment option to patients living with IBD, who currently have few therapies that repair the damaged intestinal lining at the root of their disease.

  • Experimental HIV vaccine achieves a long-sought goal
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    Experimental HIV vaccine achieves a long-sought goal

    In a first for the field, all non-human primates given a new series of vaccines generated antibodies capable of fighting multiple strains of HIV.

  • Scripps Research chemist Jin-Quan Yu is named a Fellow of the Royal Society
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    Scripps Research chemist Jin-Quan Yu is named a Fellow of the Royal Society

    Yu is honored by the U.K.’s national academy of sciences for his work in synthetic organic chemistry.

    Chemistry Jian-Quan Yu
  • Scripps Research’s Skaggs Graduate School awards doctoral degrees to 34th graduating class
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    Scripps Research’s Skaggs Graduate School awards doctoral degrees to 34th graduating class

  • Scripps Research establishes endowed chair honoring renowned structural biologist Ian Wilson
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    Scripps Research establishes endowed chair honoring renowned structural biologist Ian Wilson

    Keren Lasker to be inaugural chair holder

  • How changes to proteins can alter drug interactions for new precision therapies
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    How changes to proteins can alter drug interactions for new precision therapies

    Scripps Research team maps how chemical modifications to proteins affect drug binding across the human proteome.

  • Scripps Research immunologist Dennis Burton elected to American Academy of Arts and Sciences
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    Scripps Research immunologist Dennis Burton elected to American Academy of Arts and Sciences

    A leader in broadly neutralizing antibodies, Burton has helped drive global efforts to develop vaccines for HIV, influenza and more.

  • Scripps Research chemist Benjamin Cravatt elected to American Philosophical Society
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    Scripps Research chemist Benjamin Cravatt elected to American Philosophical Society

  • Scripps Research ranks third in 2026 Cure Innovation Index
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    Scripps Research ranks third in 2026 Cure Innovation Index

  • Jin-Quan Yu elected to the National Academy of Sciences
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    Jin-Quan Yu elected to the National Academy of Sciences

    Yu is recognized for his pioneering work in synthetic organic chemistry.

  • How a chemical reaction triggers brain inflammation in Alzheimer’s disease
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    How a chemical reaction triggers brain inflammation in Alzheimer’s disease

    Scripps Research scientists discovered that a chemically modified protein puts the brain’s immune cells in a state of damaging, chronic overactivation—and that blocking it protects brain cell connections.

  • Improving vaccine design for Ebola, HIV and more
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    Improving vaccine design for Ebola, HIV and more

    Scripps Research scientists and colleagues develop a nanodisc platform that offers a clearer view of how key viral proteins interact with antibodies.

  • NIH expected to award Scripps Research nearly $4.2 million over 5 years to advance tools for vaccine design
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    NIH expected to award Scripps Research nearly $4.2 million over 5 years to advance tools for vaccine design

    Funding will expand methods for studying viral proteins and immune responses in more realistic settings for HIV and other severe pathogens.

  • New technique for synthesizing branched molecules could accelerate the development of future medicines
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    New technique for synthesizing branched molecules could accelerate the development of future medicines

    Scripps Research chemists solve a longstanding problem in the construction of branched molecular frameworks, unlocking a faster path to the complex structures found in drugs and materials.

  • Scripps Research’s Skaggs Graduate School ranked #1 in Biological Sciences by U.S. News & World Report
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    Scripps Research’s Skaggs Graduate School ranked #1 in Biological Sciences by U.S. News & World Report

    The doctoral program also placed #7 in Chemistry in the publication’s latest issue ranking top science graduate schools.

  • Scripps Research scientists uncover new mechanism cancer cells use to survive DNA damage
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    Scripps Research scientists uncover new mechanism cancer cells use to survive DNA damage

    Discovery reshapes understanding of how tumor cells repair broken DNA, pointing toward more precise cancer therapies.

  • Study shows new drug compounds dial down inflammation without compromising immunity
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    Study shows new drug compounds dial down inflammation without compromising immunity

    First-in-class molecules block a specific protein interaction in immune cells, offering a potential targeted approach to autoimmune diseases like lupus and rheumatoid arthritis.

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