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Scripps Research scientists train the immune system to make antibodies against numerous HIV strains
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Scripps Research scientists train the immune system to make antibodies against numerous HIV strains

Joan Pulupa. Credit: Timothy White
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Joan Pulupa joins Scripps Research faculty to study the organization of DNA in brain cells and its links to neurodegeneration

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  • Numerous Scripps Research scientists named Highly Cited Researchers
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    Numerous Scripps Research scientists named Highly Cited Researchers

    Clarivate’s annual, global list represents researchers who have demonstrated significant and broad influence in their field of research.

  • Scripps Research welcomes three visionary scientists
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    Scripps Research welcomes three visionary scientists

    Immunology assistant professor Joseph Jardine and assistant neuroscience professor Chen Ran join the faculty, while RNA-targeting expert Megan Ken becomes the newest fellow

  • Scripps Research neuroscientist Li Ye honored with esteemed Chan Zuckerberg Initiative award
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    Scripps Research neuroscientist Li Ye honored with esteemed Chan Zuckerberg Initiative award

    The Ben Barres Early Career Acceleration Award recognizes Ye’s pioneering research into how the communication between our brain and body impacts neurodegenerative diseases.

  • Multiple sclerosis drug invented at Scripps Research slows long-term devastating disease progression
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    Multiple sclerosis drug invented at Scripps Research slows long-term devastating disease progression

    Late-breaking data reinforces the effectiveness and safety of ozanimod, invented in the labs of professors Hugh Rosen and Edward Roberts.

  • New cancer drug targets uncovered using base editing and chemical proteomics
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    New cancer drug targets uncovered using base editing and chemical proteomics

    Combining precise genome engineering and protein activity profiling to methodically study thousands of cancer genes, Scripps Research scientists were able to pinpoint promising cancer drug targets.

  • Keren Lasker named a 2023 Moore Inventor Fellow
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    Keren Lasker named a 2023 Moore Inventor Fellow

    The prestigious award will support Lasker’s inventive research in membraneless organelles and their application in neurodegenerative diseases.

  • Michael Bollong named a 2023 Amgen Young Investigator
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    Michael Bollong named a 2023 Amgen Young Investigator

    The prestigious award will support Bollong’s research identifying new molecular targets and therapeutics, including in regenerative organ repair.

  • Philip Dawson receives 2024 American Chemical Society National Award
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    Philip Dawson receives 2024 American Chemical Society National Award

    Dawson is honored with the Arthur C. Cope Late Careers Scholar Award for his foundational contributions in organic chemistry.

  • Scripps Research chemists devise a method for C-H activation of alcohols
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    Scripps Research chemists devise a method for C-H activation of alcohols

    The method represents a new toolkit for making drugs and other compounds.

  • Insomnia drug helps prevent oxycodone relapse, Scripps Research study shows
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    Insomnia drug helps prevent oxycodone relapse, Scripps Research study shows

    New findings suggest that treating insomnia can stop opioid-seeking behavior, even after ending treatment.

  • Scripps Research receives $1.5M to surveil infectious disease threats in wastewater
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    Scripps Research receives $1.5M to surveil infectious disease threats in wastewater

    Bill & Melinda Gates Foundation award to support the development of multi-pathogen wastewater surveillance tools and protocols.

  • How cold temperatures trigger the brain to boost appetite
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    How cold temperatures trigger the brain to boost appetite

    Scripps Research scientists’ discovery could lead to new weight loss and metabolic health treatments.

  • Scripps Research scientists reveal how sensory protein changes shape with nanometer resolution
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    Scripps Research scientists reveal how sensory protein changes shape with nanometer resolution

    The sensory receptor PIEZO1 changes shape in response to mechanical stimuli. The super high-resolution microscopy technology used in this discovery is a breakthrough in enabling protein structures to be studied within the cellular environment.

  • Human antibody that targets carfentanil, fentanyl and related opioids reverses overdose effects in preclinical study
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    Human antibody that targets carfentanil, fentanyl and related opioids reverses overdose effects in preclinical study

    Scripps Research-developed antibody therapy appears to have advantages over existing opioid-overdose treatments.

  • “Spider-like” mitochondrial structure initiates cell-wide stress response
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    “Spider-like” mitochondrial structure initiates cell-wide stress response

    Scripps Research scientists discovered the unique molecular structure, which could have implications in age-related diseases like neurodegeneration.

  • How sensory neurons impact the gut
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    How sensory neurons impact the gut

    Scripps Research scientists show that the receptor PIEZO2 in sensory neurons controls gut motility and transit time, which are important for digestion and nutrient absorption.

  • AbbVie and Calibr Expand Strategic Collaboration to Advance Several Preclinical and Early-stage Clinical Assets
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    AbbVie and Calibr Expand Strategic Collaboration to Advance Several Preclinical and Early-stage Clinical Assets

    The expanded strategic collaboration will advance several innovative assets across AbbVie’s core therapeutic growth areas including immunology, oncology, neuroscience.

  • Calibr launches first-in-human phase 1 clinical trial in healthy volunteers evaluating PDM608, an investigative drug developed for the treatment of neurodegenerative diseases
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    Calibr launches first-in-human phase 1 clinical trial in healthy volunteers evaluating PDM608, an investigative drug developed for the treatment of neurodegenerative diseases

    Calibr scientists engineered a cytokine protein that has shown evidence of providing neuroprotective effects to Parkinson’s disease patients.

  • Blocking glutamate release reduces oxycodone intake and seeking behavior
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    Blocking glutamate release reduces oxycodone intake and seeking behavior

    In a preclinical study, Scripps Research scientists show that the drug ADX106772 (Addex Therapeutics) reduced oxycodone intake and relapse, without disrupting the brain’s natural reward system.

  • Scripps Research scientists develop AI-based tracking and early-warning system for viral pandemics
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    Scripps Research scientists develop AI-based tracking and early-warning system for viral pandemics

    Machine-learning system effectively predicts emergence of prominent variants.

  • Major depressive disorder therapy to enter Phase 3 pivotal clinical trials
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    Major depressive disorder therapy to enter Phase 3 pivotal clinical trials

    Navacaprant, a monotherapy discovered at Scripps Research, showed clinically meaningful improvements for people with moderate-to-severe MDD in a recently completed Phase 2 study.

  • Scripps Research awarded $9.8 million by NIH to address deadly bacterial infections
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    Scripps Research awarded $9.8 million by NIH to address deadly bacterial infections

    The program grant will support the development of high-affinity antibodies that can target skin and lung infections, as well as sexually transmitted diseases.

  • Scripps Research mourns passing of immunology professor and virology pioneer Michael Oldstone
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    Scripps Research mourns passing of immunology professor and virology pioneer Michael Oldstone

    A leader in viral pathogenesis, Oldstone helped shape our modern understanding of viruses and how the immune system responds to these microbial threats.

  • Monitoring T cells may allow prevention of type 1 diabetes
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    Monitoring T cells may allow prevention of type 1 diabetes

    Scripps Research study shows that analyzing T cells in blood samples could be used to select at-risk patients for type 1 diabetes preventive therapy.

Groundbreaking Science.
Life-changing Medicine.