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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • New technology lets researchers track brain cells’ “off switches”
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    New technology lets researchers track brain cells’ “off switches”

    The method could shed light on what goes awry in numerous brain conditions when neurons are correctly and incorrectly activated or inhibited.

  • New immune system-targeting compounds show early promise in treating lupus
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    New immune system-targeting compounds show early promise in treating lupus

    Scripps Research scientists developed a compound that can block a protein previously considered challenging to drug and is implicated in autoimmune diseases, including lupus.

  • Three decades of giving: Announcing the Calibr-Skaggs Institute for Innovative Medicines
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    Three decades of giving: Announcing the Calibr-Skaggs Institute for Innovative Medicines

    The ALSAM Foundation, founded by the Skaggs family, provides lasting gift to Scripps Research’s drug discovery and development arm.

  • Scripps Research scientists give new insight into a molecular target of alcohol
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    Scripps Research scientists give new insight into a molecular target of alcohol

    By investigating a molecule in the brain tied to cellular communication, scientists uncover important information about the proteins that do—and do not—influence alcohol drinking behavior. 

  • 100 years of Science Changing Life: Scripps Research celebrates a century of transforming human health
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    100 years of Science Changing Life: Scripps Research celebrates a century of transforming human health

    For the last century, institute leaders and renowned scientists have made Scripps Research what it is today: the world’s leading independent and nonprofit biomedical research institute at the forefront of innovation.

  • Calibr announces license agreement with Gilead to develop a long-acting HIV antiviral agent for treatment in combination with lenacapavir
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    Calibr announces license agreement with Gilead to develop a long-acting HIV antiviral agent for treatment in combination with lenacapavir

    Long-acting combination HIV regimens have the potential to transform the future of coordinated HIV clinical care.  A Phase 1 trial has been initiated to evaluate GS-1614 - a novel prodrug of a nucleoside reverse transcriptase translocation inhibitor (NRTTI).

  • Life science entrepreneur Gene Lay joins Scripps Research Board of Directors
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    Life science entrepreneur Gene Lay joins Scripps Research Board of Directors

    Lay, founder of the global biotech company BioLegend, brings invaluable experience as an industry leader and innovator. 

  • New method illuminates druggable sites on proteins
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    New method illuminates druggable sites on proteins

    Scripps Research scientists develop a new, high-resolution technique for finding potential therapeutic targets on proteins in living cells. The findings could lead to more targeted therapeutics for nearly any human disease.

  • Novel HIV-1 vaccine candidates invented at Scripps Research to enter phase 1 clinical trial
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    Novel HIV-1 vaccine candidates invented at Scripps Research to enter phase 1 clinical trial

    Following approval from Australia’s HREC, the clinical trial investigating UVAX-1107 and UXAX-1197 will initiate in January 2024.  

  • Taming a plant-derived toxin
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    Taming a plant-derived toxin

    Scripps Research team modifies the traditional poison picrotoxinin for potential neurological drugs and anti-parasite treatments.

  • Scripps Research Executive Vice President Eric Topol gives TED talk on transformative power of AI in medicine
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    Scripps Research Executive Vice President Eric Topol gives TED talk on transformative power of AI in medicine

    Topol provides an overview of how AI models can improve diagnostic accuracy, liberate clinicians from keyboards and restore the doctor-patient relationship.

  • Social distancing was more effective at preventing local COVID-19 transmission than international border closures
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    Social distancing was more effective at preventing local COVID-19 transmission than international border closures

    Scripps Research scientists and collaborators uncovered the relative effectiveness of different COVID-19 mandates, helping guide public health policy for future viral threats.

  • New AI-powered algorithm could better assess people’s risk of common heart condition
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    New AI-powered algorithm could better assess people’s risk of common heart condition

    Early detection of atrial fibrillation can reduce the risk of stroke and heart failure, but screening people for the condition has been historically challenging.

  • “Nanoparticle” flu vaccine design shows promise in early tests
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    “Nanoparticle” flu vaccine design shows promise in early tests

    Scripps Research-designed vaccine could provide broad, enduring protection against influenza A strains, including pandemic strains

  • Numerous Scripps Research scientists named Highly Cited Researchers
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    Numerous Scripps Research scientists named Highly Cited Researchers

    Clarivate’s annual, global list represents researchers who have demonstrated significant and broad influence in their field of research.

  • Scripps Research welcomes three visionary scientists
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    Scripps Research welcomes three visionary scientists

    Immunology assistant professor Joseph Jardine and assistant neuroscience professor Chen Ran join the faculty, while RNA-targeting expert Megan Ken becomes the newest fellow

  • Scripps Research neuroscientist Li Ye honored with esteemed Chan Zuckerberg Initiative award
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    Scripps Research neuroscientist Li Ye honored with esteemed Chan Zuckerberg Initiative award

    The Ben Barres Early Career Acceleration Award recognizes Ye’s pioneering research into how the communication between our brain and body impacts neurodegenerative diseases.

  • Multiple sclerosis drug invented at Scripps Research slows long-term devastating disease progression
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    Multiple sclerosis drug invented at Scripps Research slows long-term devastating disease progression

    Late-breaking data reinforces the effectiveness and safety of ozanimod, invented in the labs of professors Hugh Rosen and Edward Roberts.

  • New cancer drug targets uncovered using base editing and chemical proteomics
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    New cancer drug targets uncovered using base editing and chemical proteomics

    Combining precise genome engineering and protein activity profiling to methodically study thousands of cancer genes, Scripps Research scientists were able to pinpoint promising cancer drug targets.

  • Keren Lasker named a 2023 Moore Inventor Fellow
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    Keren Lasker named a 2023 Moore Inventor Fellow

    The prestigious award will support Lasker’s inventive research in membraneless organelles and their application in neurodegenerative diseases.

  • Michael Bollong named a 2023 Amgen Young Investigator
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    Michael Bollong named a 2023 Amgen Young Investigator

    The prestigious award will support Bollong’s research identifying new molecular targets and therapeutics, including in regenerative organ repair.

  • Philip Dawson receives 2024 American Chemical Society National Award
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    Philip Dawson receives 2024 American Chemical Society National Award

    Dawson is honored with the Arthur C. Cope Late Careers Scholar Award for his foundational contributions in organic chemistry.

  • Scripps Research chemists devise a method for C-H activation of alcohols
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    Scripps Research chemists devise a method for C-H activation of alcohols

    The method represents a new toolkit for making drugs and other compounds.

  • Insomnia drug helps prevent oxycodone relapse, Scripps Research study shows
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    Insomnia drug helps prevent oxycodone relapse, Scripps Research study shows

    New findings suggest that treating insomnia can stop opioid-seeking behavior, even after ending treatment.

Groundbreaking Science.
Life-changing Medicine.