Cores

Animal Models Core

The Animal Models Core provides in vivo tests relevant to human diseases and the development of medications and other treatment strategies. In addition to general test batteries, the core offers panels for disorders of learning and memory, affective states, social behaviors, motor functioning, pain and sensation, sleep, metabolism, and drug and alcohol abuse and dependence. Core services include customized design and implementation of tests, including surgical procedures, drug administration protocols, and tissue collection, as well as training in all these areas.

Automated Synthesis Facility

The Automated Synthesis Facility accelerates discovery through data-rich, high-throughput experimentation, combining expertise in organic chemistry with advanced analytical and preparative chromatography and mass spectrometry. We design, execute, and deliver actionable insights that accelerate projects at every stage of the research process.

Biophysics & Biochemistry Core

The Biophysics & Biochemistry Core offers access to state-of-the-art instrumentation for characterizing protein, nucleic acid, and small molecule structures and their interactions. We support researchers by studying spectroscopic and biophysical traits of molecules, identifying structures and interactions that are essential to the drug discovery process, and elucidating biological mechanisms. We also train researchers to design and perform the experiments.

Flow Cytometry Core

The Flow Cytometry Core offers state-of-the-art instrumentation and expertise for high-speed cell sorting and spectral analysis, enabling precise cellular research and discovery.

Genomics Core

The Genomics Core provides cutting-edge genomic technologies, resources, and solutions. Our expertise includes Next-Generation Sequencing (NGS), NGS library prep, single-cell genomics, spatialomics, metagenomics, and custom microarray fabrication and analysis. In addition, the core supports experimental design, grant applications, interpretation of sequencing and microarray results, and user education. We aim to stay aligned with the ever-evolving "omics" technologies to support scientific advancements both within Scripps Research and beyond.

Gnotobiotic & Cryobank Facility

The Gnotobiotic & Cryobank Facility is an essential resource for investigators studying immunology, microbiome interactions, intestinal biology, and much more. The facility provides gnotobiotic husbandry, quality control, microbiota transplantations, sample collection, and other assays and experiments. It also provides services for cryopreservation, storage, and rederivatization of research strains.

High Performance Computing

High Performance Computing provides compute, storage, and archival capabilities in support of high-throughput scientific computation and data processing. The staff also works closely with research groups to develop computational workflows involving both on- and off-premise compute resources.

Mass Spectrometry Core

The Mass Spectrometry Core provides advanced expertise in mass spectrometry, metabolomics, lipidomics, protein analysis, pharmacology, and quantitative analysis. We support researchers through high-quality analytical workflows that enable molecular discovery and biomarker identification, and precise measurement of metabolites, lipids, proteins, and drugs across diverse biological, biomedical, and translational research applications. We also provide six mass spectrometers for Open Access analyses.

Microscopy Core

The Microscopy Core provides advanced instrumentation and expertise required for multi-dimensional imaging of cells and tissues at high resolution. Resources include widefield, fluorescence, confocal, multi-photon, TIRF, super-resolution (MINFLUX, STED, STORM) and electron microscopy (TEM and SEM). Services offered include consultation, sample preparation (EM and histology), training, imaging, and image analysis.

Normal Blood Donor Service

Normal Blood Donor Service (NBDS) provides normal human blood for scientific studies. The blood is collected from volunteer donors a central location by licensed and experienced technicians and screened for infectious agents such as HIV and the hepatitis viruses. NBDS serves both Scripps Research and scientists in the surrounding community.

Nuclear Magnetic Resonance Facility

The NMR Facility offers state-of-the-art solution-state NMR instrumentation to support chemistry and biomolecular research at Scripps Research and within the broader scientific community. In addition to routine spectroscopic services, the facility’s experienced staff implement advanced methodologies for high-resolution structural, dynamic, and kinetic studies that enable a broad range of research programs.

Protein Production Core

The Protein Production Core aims to provide the highest quality recombinant proteins and antibodies for investigators to use as diagnostic and therapeutic reagents in their research studies. We also provide testing services for mycoplasma and maintain an automatic liquid nitrogen storage system for critical cell lines.

Proteomics Core

The Proteomics Core provides mass spectrometry-based proteomics services, focusing on quantitative proteomics using label-free or multiplexed analysis. Services include analysis of samples from a wide variety of experimental designs, including but not limited to: proximity and metabolic labeling, drug target discovery, comparative analysis of affinity-based enrichments, protein-protein interactions, and post-translational modifications. Services include assistance with experimental design and data analysis.

Scripps Research Library

Scripps Research’s Kresge Library helps our research community find, evaluate, create, and use information to empower scientific discovery and improve human health. We strategically curate and share scholarly content, and develop trainings, partnerships, and user-centered tools that connect researchers with resources at any time and from anywhere.

Worm Institute for Research and Medicine

X-ray Crystallography

Small molecule X-ray crystallographic services are provided by the UCSD X-Ray Crystallography Facility, located one mile away from Scripps Research. The facility provides data collection, processing, and analysis for small molecule structure determination, including determination of absolute stereochemistry.