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Automated Synthesis Facility

About the Core

The Automated Synthesis Facility accelerates discovery through data-rich, high-throughput experimentation, combining expertise in organic chemistry with advanced analytical and preparative chromatography and mass spectrometry. We design, execute and deliver actionable insights that accelerate projects at every stage of the research process.

Equipment

Publications

  • J. Sun, Y. Hu, C. X. Liao, S. Yang, Q. N. Wong, P. Liu, K. M. Engle, "Dual catalytic C(sp2)—H activation of azaheterocycles toward C—N atropoisomers," ACS Catalysis, 2025, 15, 3700-3710. doi.org/10.1021/acscatal.4c06788

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  • N. Chakrabort, J. Momirov, A. Radakovic, S. Chatterjee, A. M. Kirchhoff, A. Kolb, T. J. West, B. B. Sanchez, S. Martinez-Bartolome, A. Saviola, D. McClatchy, J. R. Yates III, J. S. Chen, L. L. Lairson, B. H. Felding, D. L. Boger, "Insights into free drug release from efficacious N-acyl O-aminophenol duocarmycin prodrugs," ACS Chem. Biol. 2025, 20, 442-454. doi.org/10.1021/acschembio.4c00754

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  • M. Kissai, E. N. Chin, F. Martínez-Peña, A. Sulpizio, E. P. Stout, I. Usui, F. Barmare, B. Sanchez, E. Esquenazi, R. L. Stanfield, I. A. Wilson, L. L. Lairson, "Cladophorol-A is an inhibitor of cyclic GMP-AMP synthase," Bioorg. Med. Chem. Lett. 2025, 115, 130007. doi.org/10.1016/j.bmcl.2024.130007

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  • K. Simlandy, T. M. alturaifi, J. M. Nguyen, L. J. Oxtoby, Q. N. Wong, J. S. Chen, P. Liu, K. M. Engle, “Enantioselective hydroalkeylation and hydroalkynylation of alkenes enabled by a transient directing group: Catalyst generality through rigidification,” Angew. Chem. Int. Ed. 2023, 62, e202304013.

  • T. Tran, N. Kim, C. Z. Rubel, X. Wu, T. Kang, T. C. Jankins, Z.-Q. Li, W. V. Joannou, S. Ayers, M. Gembicky, J. Baily, E. J. Sturgell, B. B. Sanchez, J. S. Chen, S. Lin, M. D. Eastgate, S. R. Wisniewski, K. M. Engle, “Structurally diverse bench-stable nickel(0) pre-catalysts: A practical toolkit for in situ ligation protocols,” Angew. Chem. Int. Ed. 2023, 62, e202211794.

  • Apolinar, T. Kang, T. M. Alturaifi, P. G. Bedekar, C. Z. Rubel, J. Derosa, B. B. Sanchez, Q. N. Wong, E. J. Sturgell, J. S. Chen, S. R. Wisniewski, P. Liu, K. M. Engle, “Three-component asymmetric Ni-catalyzed 1,2-dicarbofunctionalization of unactivated alkenes via stereoselective migratory insertion,” J. Am. Chem. Soc. 2022, 144, 19337 – 19343.

  • Hao, C. L. Joe, A. Darù, S. Ayers, A. Ramirez, B. Sandhu, R. A. Daley, J. S. Chen, M. A. Schmidt, D. G. Blackmond, “Kinetic and thermodynamic considerations in the Rh-catalyzed enantioselective hydrogenation of 2-pyridyl-substituted alkenes,” ACS Catal. 2022, 12, 5961 – 5969.

  • -C. Lin, F. Schneider, K. J. Eberle, D. Chiodi, H. Nakamura, S. H. Reisberg, J. Chen, M. Saito, P. S. Baran, “Atropselective total synthesis of darobactin A,” J. Am. Chem. Soc. 2022, 144, 14458 – 14462.

  • He, Y. Wang, C. Bi, D. S. Peters, T. J. Gallagher, J. Teske, J. S. Chen, R. Corsetti, A. D’Onofrio, K. Lewis, P. S. Baran, “Total synthesis of kibdelomycin,” Angew. Chem. Int. Ed., 2022, 61, e20226183.

  • Gu, K. X. Rodriguez, Y. Kanda, S. Yang, M. Ociepa, H. Wilke, A. V. Abrishami, L. Jørgensen, T. Shak-Nielsen, J. S. Chen, P. S. Baran, “Convergent total synthesis of (+)-calcipotriol: A scalable, modular approach to vitamin D analogs,” Proc. Natl. Acad. Sci. 2022, 119, e2200814119.

  • C. Jankins, W. C. Bell, Y. Zhang, Z.-Y. Qin, J. S. Chen, M. Gembicky, P. Liu, K. M. Engle, “Low-valent tungsten redox catalysis enables controlled isomerization and carbonylative functionalization of alkenes,” Nature Chem. 2022, 14, 632 – 639.

  • Hao, C. L. Joe, S. Ayers, A. Darù, R. A. Daley, M. Domanski, J. S. Chen, M. A. Schmidt, D. G. Blackmond, “Ru-catalyzed enantioselective hydrogenation of 2-pyridyl-substituted alkenes and substrate-mediated H/D exchange,” ACS Catal. 2022, 12, 1150 – 1160.

  • G. Saint-Denis, N. Y. S. Lam, N. Chekshin, P. F. Richardson, J. S. Chen, J. Elleraas, K. D. Hesp, D. C. Schmitt, Y. Lian, C. W. Huh, J.-Q. Yu, “Mechanistic study of enantioselective Pd-catalyzed C(sp3)–H activation of thioethers involving two distinct stereomodels,” ACS Catal. 2021, 11, 9738 – 9753.

  • Ociepa, K. W. Knouse, D. He, J. C. Vantourout, D. T. Flood, N. M. Padial, J. S. Chen, B. B. Sanchez, E. J. Sturgell, B. Zheng, S. Qiu, M. A. Schmidt, M. D. Eastgate, P. S. Baran, “Mild and chemoselective phosphorylation of alcohols using a Y-reagent,” Org. Lett. 2021, 23, 9337 – 9342.

  • L. D. Turner, A. L. Nielsen, L. Lin, A. J. Campedelli, N. R. Silvaggi, J. S. Chen, A. E. Wakefield, K. N. Allen, K. D. Janda, “Use of crystallography and molecular modeling for the inhibition of the botulinum neurotoxin A protease,” ACS Med. Chem. Lett. 2021, 12, 1318 – 1324.

  • D. A. Dik, N. Zhang, E. J. Sturgell, B. B. Sanchez, J. S. Chen, B. Webb, K. G. Vanderpool, P. G. Schultz, “A synthetic 5,3-cross-link in the cell wall of rod-shaped Gram-positive bacteria,” Proc. Natl. Acad. Sci. 2021, 118, e2100137118.

  • D. T. Flood, J. C. J. Hintzen, K. W. Knouse, D. E. Hill, C. Lu, P. A. Cistrone, J. S. Chen, T. Otomo, P. E. Dawson, “Selenomethionine as an expressible handle for bioconjugations,” Proc. Natl. Acad. Sci. 2021, 118, e2005164118 D. T. Flood, K. W. Knouse, J. C. Vantourout, S. Kitamura, B. B. Sanchez, E. J. Sturgell, J. S. Chen, D. W. Wolan, P. S. Baran, P. E. Dawson, “Synthetic elaboration of native DNA by RASS (SENDR),” ACS Central Sci. 2020, 6, 1789 – 1799.

  • Z. Fan, S. Zhao, T. Liu, P.-X. Shen, Z.-N. Cui, Z. Zhuang, Q. Shao, J. S. Chen, A. S. Ratnayake, M. E. Flanagan, D. K. Kölmel, D. W. Piotrowski, P. Richardson, J.-Q. Yu, “Merging C(sp3)-H activation with DNA-encoding,” Chem. Sci. 2020, 11, 12282 – 12288.

  • N. Yan, D. Santos-Martins, E. Rennella, B. B. Sanchez, J. S. Chen, L. E. Kay, I. A. Wilson, G. J. Morgan, S. Forli, J. W. Kelly, “Structural basis for the stabilization of amyloidogenic immunoglobin light chains by hydantoins,” Bioorg. Med. Chem. Lett. 2020, 30, article 127356.

  • A. X. Jones, L. Wen, L. Legnani, J. Chen, D. G. Blackmond, “Asymmetric amplification in peptide-catalyzed formation of tetrose sugars from nearly racemic amino acids,” J. Systems Chem. 2020, 8, 63 - 72.

  • D. A. Dik, N. Zhang, J. S. Chen, B. Webb, P. G. Schultz, “Semi-synthesis of a bacterium with non-canonical cell wall crosslinks,” J. Am. Chem. Soc. 2020, 142, 10910 – 10913.

  • Y. Wang, J. Sun, Y. Li, D. A. Cagan, O. T. Ring, X. Zheng, L. Massaro, J. E. Smith, B. J. Orzolek, M. R. Collins, Y. Kawamata, P. S. Baran, "Stereoretentive radical-based alkyl-alkyl cross-coupling," Science, 2026, 392 (6802), 1075-1081.

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