Our scientists investigate cancer at multiple levels, from individual proteins to whole cells and tissues. We map how cancer starts, adapts and spreads in order to uncover new strategies to detect and treat this oftentimes devastating disease.
Nearly 1 in 5 deaths are caused by cancer worldwide, according to the World Health Organization. Cancer can arise when cells grow out of control, often by hijacking the body’s biological processes.
Here at Scripps Research, our scientists are investigating cancer at multiple levels—from the chemistry of individual proteins to the behavior of whole cells and tissues—to uncover vulnerabilities and translate them into new therapies. Through our drug-discovery arm, the Calibr-Skaggs Institute for Innovative Medicines, we can advance promising ideas toward clinical development.
For more information on our cancer research programs, please contact us.
Scientists find cancer weak spot in backup DNA repair system
New findings from Scripps Research reveal how certain tumors survive DNA damage—and point to a strategy for targeting them.
Cancer isn’t a single disease—there are so many tumor types, and they’re completely different from each other. Disruption of circadian rhythms increases tumor formation in various kinds of cancer.
Our scientists pursue multiple angles to outsmart cancer—from understanding how tumors evolve to designing therapies that home in on the right cells at the right time.
Our scientists use advanced proteomics, metabolomics and other molecular tools to identify biological signatures of cancer. These biomarkers can reveal how tumors develop, progress or respond to treatment, and may help guide earlier detection strategies or more personalized therapies.
Cancer cells can rapidly evolve in response to therapy. We study how tumors repair DNA damage, alter signaling networks and adapt to survive drug treatment. Understanding these escape mechanisms helps researchers design therapies that remain effective longer or prevent resistance from emerging.
Many proteins linked to cancer are difficult to block using traditional drugs. Scientists at Scripps Research are developing new chemical strategies to act on these challenging targets, discovering compounds that can modulate the activity of proteins involved in tumor growth and survival.
