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Animal Models Core
Scripps Research animal models core scientist working under red light conditions in a specialized animal care facility.

About the Core

Scripps Research Animal Models Core Facility has been established to provide a wide range of in vivo tests to the Scripps Research community as well as to the greater San Diego research community and beyond. A primary focus of this core is to provide tests that allow investigators to make transitions from laboratory findings to clinical applications by enabling the modeling of human diseases and the development of medications and other treatment strategies.

For example, in addition to general test batteries, specific panels have been developed for neuropsychiatric disorders, including anxiety disorders, depressive disorders, disorders of learning and memory, disorders of motor functioning, sleep disorders, and drug and alcohol abuse and dependence. Core services include designing and implementing specific behavioral tests, general test batteries, surgical procedures, and drug administration protocols, as well as training in all of these areas. Included in a service package is experimental design advice, assistance with IACUC animal protocol submission, assistance with writing descriptions of these tests in grant proposals and manuscripts, data analysis, and results interpretation.

Service Categories

Publications

  • Turner NP, Bajo M, Roberts AJ, Roberto M, Yates JR 3rd. The effects of alcohol dependence on the CSF proteome in mice: Evidence for blood-brain barrier dysfunction and neuroinflammation. Neurobiol Dis. 2025 Dec 30;219:107254. doi: 10.1016/j.nbd.2025.107254. Epub ahead of print. PMID: 41478511.

  • Hashimoto JG, Mangieri RA, Roberts AJ, Lime T, Davis BA, Carbone L, Roberto M, Guizzetti M. Alcohol dependence-induced astrocyte immune activation in the nucleus accumbens. Neurobiol Dis. 2025 Dec;217:107171. doi: 10.1016/j.nbd.2025.107171. Epub 2025 Nov 3. PMID: 41192645; PMCID: PMC12721001.

  • Restagno D, Saraswat M, Aziz PV, Smith K, Roberts AJ, Hintze J, Marth JD. Mrc1 (MMR, CD206) controls the blood proteome in reducing inflammation, age-associated organ dysfunction and mortality in sepsis. Nat Commun. 2025 Jul 7;16(1):6267. doi: 10.1038/s41467-025-61346-4. PMID: 40624023; PMCID: PMC12234678.

  • Borgonetti V, St Onge CM, Cruz B, Zalfa C, Nadav T, Roberts AJ, Galeotti N, Bajo M, Roberto M. Targeting IL-6 as a novel therapeutic approach for alcohol abstinence - related mechanical allodynia. Neuropharmacology. 2025 Nov 1;278:110584. doi: 10.1016/j.neuropharm.2025.110584. Epub 2025 Jun 28. PMID: 40588184; PMCID: PMC12341569.

  • Favoretto CA, Nguyen A, Chacon GR, Roberts AJ, Nadav T, Ranjan S, Bertotto LB, Cruz FC, Zorrilla EP. Impacts of chronic intermittent ethanol vapor and predator odor on ethanol intake and striatal D1 and CB1 cannabinoid receptor-expressing medium spiny neurons. Front Neurosci. 2025 May 27;19:1568952. doi: 10.3389/fnins.2025.1568952. PMID: 40497136; PMCID: PMC12149174.

  • Vozella V, Borgonetti V, Cruz B, Onge CMS, Bullard R, Vlkolinsky R, Ceballos DG, Ozburn AR, Roberts AJ, Ciccocioppo R, Bajo M, Roberto M. Apremilast reduces co-occurring alcohol drinking and mechanical allodynia and regulates central amygdala GABAergic transmission. JCI Insight. 2025 Apr 22;10(8):e189732. doi: 10.1172/jci.insight.189732. PMID: 40260918; PMCID: PMC12016922.

  • Banerjee P, Wang Y, Carnevale LN, Patel P, Raspur CK, Tran N, Zhang X, Natarajan R, Roberts AJ, Baran PS, Lipton SA. diAcCA, a Pro-Drug for Carnosic Acid That Activates the Nrf2 Transcriptional Pathway, Shows Efficacy in the 5xFAD Transgenic Mouse Model of Alzheimer's Disease. Antioxidants (Basel). 2025 Feb 28;14(3):293. doi: 10.3390/antiox14030293. PMID: 40227330; PMCID: PMC11939361.

  • Harahap-Carrillo IS, Fok D, Wong F, Malik G, Maung R, Qiu X, Ojeda-Juárez D, Thaney VE, Sanchez AB, Godzik A, Roberts AJ, Kaul M. Chronic, Low-Dose Methamphetamine Reveals Sexual Dimorphism of Memory Performance, Histopathology, and Gene Expression Affected by HIV-1 Tat Protein in a Transgenic Model of NeuroHIV. Viruses. 2025 Feb 28;17(3):361. doi: 10.3390/v17030361. PMID: 40143289; PMCID: PMC11946854.

  • Alvarez-Kuglen M, Ninomiya K, Qin H, Rodriguez D, Fiengo L, Farhy C, Hsu WM, Kirk B, Havas A, Feng GS, Roberts AJ, Anderson RM, Serrano M, Adams PD, Sharpee TO, Terskikh AV. ImAge quantitates aging and rejuvenation. Nat Aging. 2024 Sep;4(9):1308-1327. doi: 10.1038/s43587-024-00685-1. Epub 2024 Aug 29. PMID: 39210148.

  • Jones JA, Zhou J, Dong J, Huitron-Resendiz S, Boussaty E, Chavez E, Wei N, Dumitru CD, Morodomi Y, Kanaji T, Ryan AF, Friedman R, Zhou T, Kanaji S, Wortham M, Schenk S, Roberts AJ, Yang XL. Murine nuclear tyrosyl-tRNA synthetase deficiency leads to fat storage deficiency and hearing loss. J Biol Chem. 2024 Oct;300(10):107756. doi: 10.1016/j.jbc.2024.107756. Epub 2024 Sep 12. PMID: 39260699; PMCID: PMC11470617.

  • Lim EW, Fallon RJ, Bates C, Ideguchi Y, Nagasaki T, Handzlik MK, Joulia E, Bonelli R, Green CR, Ansell BRE, Kitano M, Polis I, Roberts AJ, Furuya S, Allikmets R, Wallace M, Friedlander M, Metallo CM, Gantner ML. Serine and glycine physiology reversibly modulate retinal and peripheral nerve function. Cell Metab. 2024 Oct 1;36(10):2315-2328.e6. doi: 10.1016/j.cmet.2024.07.021. Epub 2024 Aug 26. PMID: 39191258.

  • Patel RR, Gandhi P, Spencer K, Salem NA, Erikson CM, Borgonetti V, Vlkolinsky R, Rodriguez L, Nadav T, Bajo M, Roberts AJ, Dayne Mayfield R, Roberto M. Functional and morphological adaptation of medial prefrontal corticotropin releasing factor receptor 1-expressing neurons in male mice following chronic ethanol exposure. Neurobiol Stress. 2024 Jun 17;31:100657. doi: 10.1016/j.ynstr.2024.100657. PMID: 38983690; PMCID: PMC11231756.

  • Chen XQ, Becker A, Albay R, Nguyen PD, Karachentsev D, Roberts AJ, Rynearson KD, Tanzi RE, Mobley WC. γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome. Ann Neurol. 2024 May 15. doi: 10.1002/ana.26958. Epub ahead of print. PMID: 38747498.

  • Yuan NY, Medders KE, Sanchez AB, Shah R, de Rozieres CM, Ojeda-Juárez D, Maung R, Williams R, Gelman BB, Baaten BJ, Roberts AJ, Kaul M. A critical role for Macrophage-derived Cysteinyl-Leukotrienes in HIV-1 induced neuronal injury. Brain Behav Immun. 2024 Feb 27;118:149-166. doi: 10.1016/j.bbi.2024.02.023. Epub ahead of print. PMID: 38423397.

  • Singh H, Koury J, Maung R, Roberts AJ, Kaul M. Interferon-β deficiency alters brain response to chronic HIV-1 envelope protein exposure in a transgenic model of NeuroHIV. Brain Behav Immun. 2024 Feb 13;118:1-21. doi: 10.1016/j.bbi.2024.02.014. Epub ahead of print. PMID: 38360376.

  • Mason BJ, Estey D, Roberts A, de Guglielmo G, George O, Light J, Stoolmiller M, Quello S, Skinner M, Shadan F, Begovic A, Kyle MC, Harris RA. A reverse translational study of PPAR-α agonist efficacy in human and rodent models relevant to alcohol use disorder. Neurobiol Stress. 2024 Jan 5;29:100604. doi: 10.1016/j.ynstr.2023.100604. PMID: 38292518; PMCID: PMC10825428.

  • Salem NA, Manzano L, Keist MW, Ponomareva O, Roberts AJ, Roberto M, Mayfield RD. Cell-type brain-region specific changes in prefrontal cortex of a mouse model of alcohol dependence. Neurobiol Dis. 2024 Jan;190:106361. doi: 10.1016/j.nbd.2023.106361. Epub 2023 Nov 20. PMID: 37992784.

  • Okhuarobo A, Kreifeldt M, Gandhi PJ, Lopez C, Martinez B, Fleck K, Bajo M, Bhattacharyya P, Dopico AM, Roberto M, Roberts AJ, Homanics GE, Contet C. Ethanol's interaction with BK channel α subunit residue K361 does not mediate behavioral responses to alcohol in mice. Mol Psychiatry. 2023 Dec 22. doi: 10.1038/s41380-023-02346-y. Epub ahead of print. PMID: 38135755.

  • Siddiqi MT, Podder D, Pahng AR, Athanason AC, Nadav T, Cates-Gatto C, Kreifeldt M, Contet C, Roberts AJ, Edwards S, Roberto M, Varodayan FP. Prefrontal cortex glutamatergic adaptations in a mouse model of alcohol use disorder. Addict Neurosci. 2023 Dec 15;9:100137. doi: 10.1016/j.addicn.2023.100137. Epub 2023 Nov 14. PMID: 38152067; PMCID: PMC10752437.

  • Gruol DL, Calderon D, Huitron-Resendiz S, Cates-Gatto C, Roberts AJ. Impact of Elevated Brain IL-6 in Transgenic Mice on the Behavioral and Neurochemical Consequences of Chronic Alcohol Exposure. Cells. 2023; 12(18):2306. https://doi.org/10.3390/cells12182306

  • Overk C, Fiorini E, Babolin C, Vukicevic M, Morici C, Madani R, Eligert V, Kosco-Vilbois M, Roberts A, Becker A, Pfeifer A, Mobley WC. Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior. Front Neurosci. 2023 Jun 28;17:1202208. doi: 10.3389/fnins.2023.1202208. PMID: 37449271; PMCID: PMC10336548.

  • Sanna PP, Cabrelle C, Kawamura T, Mercatelli D, O'Connor N, Roberts AJ, Repunte-Canonigo V, Giorgi FM. A History of Repeated Alcohol Intoxication Promotes Cognitive Impairment and Gene Expression Signatures of Disease Progression in the 3xTg Mouse Model of Alzheimer's Disease. eNeuro. 2023 Jul 7;10(7):ENEURO.0456-22.2023. doi: 10.1523/ENEURO.0456-22.2023. PMID: 37308288.

  • Athanason AC, Nadav T, Cates-Gatto C, Roberts AJ, Roberto M, Varodayan FP. Chronic ethanol alters adrenergic receptor gene expression and produces cognitive deficits in male mice. Neurobiol Stress. 2023 Apr 27;24:100542. doi: 10.1016/j.ynstr.2023.100542. PMID: 37197395; PMCID: PMC10184141.

  • Borgonetti V, Roberts AJ, Bajo M, Galeotti N, Roberto M. Chronic alcohol induced mechanical allodynia by promoting neuroinflammation: a mouse model of alcohol-evoked neuropathic pain. Br J Pharmacol. 2023 Apr 12. doi: 10.1111/bph.16091. Epub ahead of print. PMID: 37050867.

  • Varodayan FP, Pahng AR, Davis TD, Gandhi P, Bajo M, Steinman MQ, Kiosses WB, Blednov YA, Burkart MD, Edwards S, Roberts AJ, Roberto M. Chronic ethanol induces a pro-inflammatory switch in interleukin-1β regulation of GABAergic signaling in the medial prefrontal cortex of male mice. Brain Behav Immun. 2023 May;110:125-139. doi: 10.1016/j.bbi.2023.02.020. Epub 2023 Feb 28. PMID: 36863493; PMCID: PMC10106421.

  • Gruol DL, Calderon D, French K, Melkonian C, Huitron-Resendiz S, Cates-Gatto C, Roberts AJ. Neuroimmune interactions with binge alcohol drinking in the cerebellum of IL-6 transgenic mice. Neuropharmacology. 2023 Feb 10:109455. doi: 10.1016/j.neuropharm.2023.109455. Epub ahead of print. PMID: 36775097.

  • Grigsby KB, Mangieri RA, Roberts AJ, Lopez MF, Firsick EJ, Townsley KG, Beneze A, Bess J, Eisenstein TK, Meissler JJ, Light JM, Miller J, Quello S, Shadan F, Skinner MH, Aziz HC, Metten P, Morissett RA, Crabbe JC, Roberto M, Becker HC, Mason BJ, Ozburn AR. Pre-clinical and clinical evidence for suppression of alcohol intake by apremilast. J Clin Invest. 2023 Jan 19:e159103. doi: 10.1172/JCI159103. Epub ahead of print. PMID: 36656645.

  • Lordén G, Wozniak JM, Doré K, Dozier LE, Cates-Gatto C, Patrick GN, Gonzalez DJ, Roberts AJ, Tanzi RE, Newton AC. Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model. Nat Commun. 2022 Nov 23;13(1):7200. doi: 10.1038/s41467-022-34679-7. PMID: 36418293; PMCID: PMC9684486.

  • Oh CK, Nakamura T, Beutler N, Zhang X, Piña-Crespo J, Talantova M, Ghatak S, Trudler D, Carnevale LN, McKercher SR, Bakowski MA, Diedrich JK, Roberts AJ, Woods AK, Chi V, Gupta AK, Rosenfeld MA, Kearns FL, Casalino L, Shaabani N, Liu H, Wilson IA, Amaro RE, Burton DR, Yates JR 3rd, Becker C, Rogers TF, Chatterjee AK, Lipton SA. Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection. Nat Chem Biol. 2022 Sep 29. doi: 10.1038/s41589-022-01149-6. Epub ahead of print. PMID: 36175661.

  • Patel RR, Wolfe SA, Borgonetti V, Gandhi PJ, Rodriguez L, Snyder AE, D'Ambrosio S, Bajo M, Domissy A, Head S, Contet C, Dayne Mayfield R, Roberts AJ, Roberto M. Ethanol withdrawal-induced adaptations in prefrontal corticotropin releasing factor receptor 1-expressing neurons regulate anxiety and conditioned rewarding effects of ethanol. Mol Psychiatry. 2022 Aug;27(8):3441-3451. doi: 10.1038/s41380-022-01642-3. Epub 2022 Jun 6. PMID: 35668157; PMCID: PMC9708587.

  • Ledderose JMT, Benitez JA, Roberts AJ, Reed R, Bintig W, Larkum ME, Sachdev RNS, Furnari F, Eickholt BJ. The impact of phosphorylated PTEN at threonine 366 on cortical connectivity and behaviour. Brain. 2022 May 23:awac188. doi: 10.1093/brain/awac188. Epub ahead of print. PMID: 35603900.

  • Gutierrez A, Creehan KM, de Guglielmo G, Roberts AJ, Taffe MA. Behavioral effects of ethanol in the Red Swamp Crayfish (Procambarus clarkii). J Exp Anal Behav. 2022 Mar 9. doi: 10.1002/jeab.746. Epub ahead of print. PMID: 35261037.

  • Ferguson LB, Roberts AJ, Mayfield RD, Messing RO. Blood and brain gene expression signatures of chronic intermittent ethanol consumption in mice. PLoS Comput Biol. 2022 Feb 17;18(2):e1009800. doi: 10.1371/journal.pcbi.1009800. PMID: 35176017; PMCID: PMC8853518.

  • Walker SM, Malkmus S, Eddinger K, Steinauer J, Roberts AJ, Shubayev VI, Grafe MR, Powell SB, Yaksh TL. Evaluation of neurotoxicity and long-term function and behavior following intrathecal 1 % 2-chloroprocaine in juvenile rats. Neurotoxicology. 2022 Jan;88:155-167. doi: 10.1016/j.neuro.2021.11.010. Epub 2021 Nov 18. PMID: 34801587.

  • Zhu M, Echeveste Sanchez M, Douglass EA, Jahad JV, Hanback TD, Guhr Lee TN, Esther CR Jr, Cole M, Roberts AJ, Herman MA. Electronic Nicotine Vapor Exposure Produces Differential Changes in Central Amygdala Neuronal Activity, Thermoregulation and Locomotor Behavior in Male Mice. eNeuro. 2021 Aug 11;8(4):ENEURO.0189-21.2021. doi: 10.1523/ENEURO.0189-21.2021. PMID: 34321216; PMCID: PMC8362686.

  • Bakowski MA, Beutler N, Wolff KC, Kirkpatrick MG, Chen E, Nguyen TH, Riva L, Shaabani N, Parren M, Ricketts J, Gupta AK, Pan K, Kuo P, Fuller M, Garcia E, Teijaro JR, Yang L, Sahoo D, Chi V, Huang E, Vargas N, Roberts AJ, Das S, Ghosh P, Woods AK, Joseph SB, Hull MV, Schultz PG, Burton DR, Chatterjee AK, McNamara CW, Rogers TF. Drug repurposing screens identify chemical entities for the development of COVID-19 interventions. Nat Commun. 2021 Jun 3;12(1):3309. doi: 10.1038/s41467-021-23328-0. PMID: 34083527; PMCID: PMC8175350.

  • Moreno AM, Alemán F, Catroli GF, Hunt M, Hu M, Dailamy A, Pla A, Woller SA, Palmer N, Parekh U, McDonald D, Roberts AJ, Goodwill V, Dryden I, Hevner RF, Delay L, Gonçalves Dos Santos G, Yaksh TL, Mali P. Long-lasting analgesia via targeted in situ repression of NaV1.7 in mice. Sci Transl Med. 2021 Mar 10;13(584):eaay9056. doi: 10.1126/scitranslmed.aay9056. PMID: 33692134.

  • Frank K, Abeynaike S, Nikzad R, Patel RR, Roberts AJ, Roberto M, Paust S. Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice. PLoS One. 2020 Dec 21;15(12):e0239246. doi: 10.1371/journal.pone.0239246. PMID: 33347446.

  • Patel RR, Wolfe SA, Bajo M, Abeynaike S, Pahng A, Borgonetti V, D'Ambrosio S, Nikzad R, Edwards S, Paust S, Roberts AJ, Roberto M. IL-10 normalizes aberrant amygdala GABA transmission and reverses anxiety-like behavior and dependence-induced escalation of alcohol intake. Prog Neurobiol. 2020 Nov 13:101952. doi: 10.1016/j.pneurobio.2020.101952. Epub ahead of print. PMID: 33197496.

  • Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020 Feb 13;5(3):e131277. doi: 10.1172/jci.insight.131277. PMID: 32051339; PMCID: PMC7098802.

  • Ichu TA, Reed A, Ogasawara D, Ulanovskaya O, Roberts A, Aguirre CA, Bar-Peled L, Gao J, Germain J, Barbas S, Masuda K, Conti B, Tontonoz P, Cravatt BF. ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease. Biochemistry. 2020 May 19;59(19):1793-1799. doi: 10.1021/acs.biochem.0c00292. Epub 2020 May 4. PMID: 32364701; PMCID: PMC7394188.

  • Singh H, Ojeda-Juárez D, Maung R, Shah R, Roberts AJ, Kaul M. A pivotal role for Interferon-α receptor-1 in neuronal injury induced by HIV-1. J Neuroinflammation. 2020;17(1):226. Published 2020 Jul 29. doi:10.1186/s12974-020-01894-2

  • Warden AS, Wolfe SA, Khom S, et al. Microglia Control Escalation of Drinking in Alcohol-Dependent Mice: Genomic and Synaptic Drivers [published online ahead of print, 2020 May 19]. Biol Psychiatry. 2020;S0006-3223(20)31598-5. doi:10.1016/j.biopsych.2020.05.011

  • Gruol DL, Melkonian C, Ly K, Sisouvanthong J, Tan Y, Roberts AJ. Alcohol and IL-6 Alter Expression of Synaptic Proteins in Cerebellum of Transgenic Mice with Increased Astrocyte Expression of IL-6 [published online ahead of print, 2020 Jul 4]. Neuroscience. 2020;442:124-137. doi:10.1016/j.neuroscience.2020.06.043

  • Gruol DL, Hernandez RV, Roberts A. Alcohol Enhances Responses to High Frequency Stimulation in Hippocampus from Transgenic Mice with Increased Astrocyte Expression of IL-6. Cell Mol Neurobiol. 2020 Jun 19:10.1007/s10571-020-00902-6. doi: 10.1007/s10571-020-00902-6. Epub ahead of print. PMID: 32562098; PMCID: PMC7749046.

  • Gruol DL, Melkonian C, Huitron-Resendiz S, Roberts AJ. Alcohol alters IL-6 Signal Transduction in the CNS of Transgenic Mice with Increased Astrocyte Expression of IL-6 [published online ahead of print, 2020 May 23]. Cell Mol Neurobiol. 2020;10.1007/s10571-020-00879-2. doi:10.1007/s10571-020-00879-2

  • Roberts AJ, Khom S, Bajo M, Vlkolinsky R, Polis I, Cates-Gatto C, Roberto M, Gruol DL. Increased IL-6 expression in astrocytes is associated with emotionality, alterations in central amygdala GABAergic transmission, and excitability during alcohol withdrawal. Brain Behav Immun. 2019 Nov;82:188-202. doi: 10.1016/j.bbi.2019.08.185. Epub 2019 Aug 19. PubMed PMID: 31437534; PubMed Central PMCID: PMC6800653.

  • Ojeda-Juárez D, Shah R, Fields JA, et al. Lipocalin-2 mediates HIV-1 induced neuronal injury and behavioral deficits by overriding CCR5-dependent protection [published online ahead of print, 2020 Jun 11]. Brain Behav Immun. 2020;S0889-1591(20)30332-9.

  • Pinto-Duarte A, Roberts AJ, Ouyang K, Sejnowski TJ. Impairments in remote memory caused by the lack of Type 2 IP(3) receptors. Glia. 2019 Oct;67(10):1976-1989. doi: 10.1002/glia.23679. Epub 2019 Jul 26. PubMed PMID: 31348567.

  • Blednov YA, Bajo M, Roberts AJ, Da Costa AJ, Black M, Edmunds S, Mayfield J, Roberto M, Homanics GE, Lasek AW, Hitzemann RJ, Harris RA. Scn4b regulates the hypnotic effects of ethanol and other sedative drugs. Genes Brain Behav. 2019 Jul;18(6):e12562. doi: 10.1111/gbb.12562. Epub 2019 May 2. PubMed PMID: 30817077; PubMed Central PMCID: PMC6612599.

  • Patel RR, Khom S, Steinman MQ, Varodayan FP, Kiosses WB, Hedges DM, Vlkolinsky R, Nadav T, Polis I, Bajo M, Roberts AJ, Roberto M. IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala. Brain Behav Immun. 2019 Jan;75:208-219. doi: 10.1016/j.bbi.2018.10.009. Epub 2018 Oct 26. PubMed PMID: 30791967; PubMed Central PMCID: PMC6383367.

  • Ogasawara D, Ichu TA, Vartabedian VF, Benthuysen J, Jing H, Reed A, Ulanovskaya OA, Hulce JJ, Roberts A, Brown S, Rosen H, Teijaro JR, Cravatt BF. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo. Nat Chem Biol. 2018 Dec;14(12):1099-1108. doi: 10.1038/s41589-018-0155-8. Epub 2018 Nov 12. PubMed PMID: 30420694; PubMed Central PMCID: PMC6263940.

  • Courchet V, Roberts AJ, Meyer-Dilhet G, Del Carmine P, Lewis TL Jr, Polleux F, Courchet J. Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice. Nat Commun. 2018 Oct 16;9(1):4289. doi: 10.1038/s41467-018-06584-5. PubMed PMID: 30327473; PubMed Central PMCID: PMC6191442.

  • Long JZ, Roche AM, Berdan CA, Louie SM, Roberts AJ, Svensson KJ, Dou FY, Bateman LA, Mina AI, Deng Z, Jedrychowski MP, Lin H, Kamenecka TM, Asara JM, Griffin PR, Banks AS, Nomura DK, Spiegelman BM. Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception. Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6937-E6945. PMID: 29967167

  • Gruol DL, Huitron-Resendiz S, Roberts AJ. Altered brain activity during withdrawal from chronic alcohol is associated with changes in IL-6 signal transduction and GABAergic mechanisms in transgenic mice with increased astrocyte expression of IL-6. Neuropharmacology. 2018 Aug;138:32-46. PMID: 29787738.

  • Roberts AJ, Casal L, Huitron-Resendiz S, Thompson T, Tarantino LM. Intravenous cocaine self-administration in a panel of inbred mouse strains differing in acute locomotor sensitivity to cocaine. Psychopharmacology (Berl). 2018 Apr;235(4):1179-1189. PMID: 29423710.

  • Bray JG, Reyes KC, Roberts AJ, Gruol DL. Altered hippocampal synaptic function in transgenic mice with increased astrocyte expression of CCL2 after withdrawal from chronic alcohol. Neuropharmacology. 2018; 135:113-125. PMCID:PMC5975123

  • Huitron-Resendiz S, Nadav T, Krause S, Cates-Gatto C, Polis I, Roberts AJ. Effects of Withdrawal from Chronic Intermittent Ethanol Exposure on Sleep Characteristics of Female and Male Mice. Alcohol Clin Exp Res. 2018 Mar;42(3):540-550. PMCID: PMC5832570.
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