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Scripps Research scientists train the immune system to make antibodies against numerous HIV strains
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Scripps Research scientists train the immune system to make antibodies against numerous HIV strains

Joan Pulupa. Credit: Timothy White
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Joan Pulupa joins Scripps Research faculty to study the organization of DNA in brain cells and its links to neurodegeneration

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  • Researchers identify brain region involved in oxycodone relapse
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    Researchers identify brain region involved in oxycodone relapse

    Study by Scripps Research scientists suggests future therapies for opioid and alcohol addiction.

  • Nine new faculty join Scripps Research
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    Nine new faculty join Scripps Research

    The newly appointed faculty are making transformative discoveries in areas ranging across drug discovery, neuroscience, chemistry, immunity and more.

  • Advancing toward a preventative HIV vaccine
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    Advancing toward a preventative HIV vaccine

    Across four preclinical studies, Scripps Research, IAVI, and additional collaborators make headway in stimulating the rare antibodies needed to fight HIV.

    Jon Steichen
  • Keary Engle Named Dean of Scripps Research’s Skaggs Graduate School of Chemical and Biological Sciences
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    Keary Engle Named Dean of Scripps Research’s Skaggs Graduate School of Chemical and Biological Sciences

    Scripps Research has appointed Professor Keary Engle to the role of Dean of Graduate and Postdoctoral Studies, effective July 1, 2024, and will lead the institute's Skaggs Graduate School of Chemical and Biological Sciences and other education and training programs.

  • A new method for improving checkpoint inhibitor therapy for cancer
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    A new method for improving checkpoint inhibitor therapy for cancer

    Scripps Research scientists found that a “one-two punch” of combining the immunosuppressive drug ruxolitinib with existing checkpoint inhibitor therapies may be a more effective way to fight some cancers, including Hodgkin lymphoma.

  • Neuroscientist Xin Jin granted Pew and McKnight awards
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    Neuroscientist Xin Jin granted Pew and McKnight awards

    Jin is named a 2024 Pew Scholar and receives the McKnight Scholar Award, supporting her research in mapping the genes and cell types in brain development.

  • Esteemed life sciences attorney Barbara Kosacz joins Scripps Research Board of Directors
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    Esteemed life sciences attorney Barbara Kosacz joins Scripps Research Board of Directors

    Scripps Research’s vision to translate basic scientific discovery into effective treatments that benefit human health strikes a chord with Barbara Kosacz, JD—making her addition to the institution’s Board of Directors fitting.

  • Scripps Research’s Skaggs Graduate School awards doctoral degrees to 32nd graduating class
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    Scripps Research’s Skaggs Graduate School awards doctoral degrees to 32nd graduating class

    Skaggs family also honored at commencement ceremony as first recipients of Scripps Research Presidential Medal

  • Scripps Research scientists uncover new molecular drivers of Alzheimer’s
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    Scripps Research scientists uncover new molecular drivers of Alzheimer’s

    By recording detailed electrical and protein measurements of individual brain cells, researchers revealed new potential drug targets for the neurodegenerative disease.

  • Drug-like inhibitor shows promise in preventing flu
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    Drug-like inhibitor shows promise in preventing flu

    Scripps Research scientists have developed a potential drug-like molecule that blocks the first stage of type A influenza infection.

  • New method to reveal what drives brain diseases
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    New method to reveal what drives brain diseases

    Scripps Research scientists develop CRISPR screen technology to determine disease mechanism from tissues with accelerated speed.

  • Scripps Research chemists develop new method for making gamma chiral centers on simple carboxylic acids
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    Scripps Research chemists develop new method for making gamma chiral centers on simple carboxylic acids

    C-H activation-based method should speed drug molecule design and diversification.

  • Scripps Research chemist Donna Blackmond elected to the Royal Society of the U.K.
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    Scripps Research chemist Donna Blackmond elected to the Royal Society of the U.K.

    Blackmond’s wide-ranging work has shaped origin of life theories, our understanding of complex organic reaction mechanisms, drug development and much more.

  • Professor emeritus John (Jack) Johnson elected to the National Academy of Sciences
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    Professor emeritus John (Jack) Johnson elected to the National Academy of Sciences

    Johnson’s multi-disciplinary research has been instrumental in shaping our modern understanding of viruses.

  • TIME100 Health list features Scripps Research Executive Vice President Eric Topol
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    TIME100 Health list features Scripps Research Executive Vice President Eric Topol

    New list honors 100 individuals who most influenced global health in 2024.

  • New technique improves T cell-based immunotherapies for solid tumors
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    New technique improves T cell-based immunotherapies for solid tumors

    Scripps Research scientists help T cells more effectively kill solid tumors cells in vitro and in mice by tweaking an existing cancer immunotherapy.

  • New copper-catalyzed C-H activation strategy from Scripps Research
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    New copper-catalyzed C-H activation strategy from Scripps Research

    Two-mode reactions inspired by human detox enzymes offer powerful new tools for drug discovery and optimization

  • Scripps Research chemists devise easier new method for making a common type of building block for drugs
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    Scripps Research chemists devise easier new method for making a common type of building block for drugs

    Scientists transform simple linear amines into saturated heterocycles—ring-shaped structures critical for drug development.

  • Scripps Research study reveals new approach for combating “resting” bacteria
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    Scripps Research study reveals new approach for combating “resting” bacteria

    Blocking long phosphate molecules could eventually help treat chronic infections in which slow-growing bacteria evade typical antibiotics.

  • How a new drug prototype regenerates lung tissue
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    How a new drug prototype regenerates lung tissue

    A new study from Scripps Research and Calibr-Skaggs scientists provides pharmacological proof of concept for an upcoming phase 1 clinical trial.

  • A simple, inexpensive way to make carbon atoms bind together
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    A simple, inexpensive way to make carbon atoms bind together

    A Scripps Research team uncovers a cost-effective method for producing quaternary carbon molecules, which are critical for drug development.

  • Developing a vaccine for the “zombie drug” xylazine
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    Developing a vaccine for the “zombie drug” xylazine

    Scripps Research chemical biologists design an early “proof-of-concept” vaccine that could lead to the first effective treatment of xylazine overdose in people.

  • New enzyme models reveal key disease insights
    News

    New enzyme models reveal key disease insights

    Scripps Research scientists create near-atomic-level structural models of enzymes associated with autoimmune and inflammatory diseases, including lupus and Alzheimer’s.

  • How blocking a neural receptor responsible for addiction could reduce alcohol use
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    How blocking a neural receptor responsible for addiction could reduce alcohol use

    A Scripps Research team found that a new therapeutic that targets the kappa opioid receptor in the brain may reduce alcohol dependence.

Groundbreaking Science.
Life-changing Medicine.