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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • NIH awards two Scripps Research fellows more than $1 million each for their high-risk, high-impact work
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    NIH awards two Scripps Research fellows more than $1 million each for their high-risk, high-impact work

    Fellows Shannon Miller and Megan Ken have both received NIH Director’s Awards from the NIH Common Fund’s High-Risk, High-Reward Research program.

  • Professor Stuart Lipton awarded $5 million to study the chemical biology of air pollution on the human brain
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    Professor Stuart Lipton awarded $5 million to study the chemical biology of air pollution on the human brain

    The grant from the NIA/NIH will support research into how air pollution could lead to the development of Alzheimer’s disease.

  • Seeing double: Designing drugs that target “twin” cancer proteins
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    Seeing double: Designing drugs that target “twin” cancer proteins

    Scripps Research scientists used knowledge about a protein to characterize drugs that selectively bind to its “twin,” or paralog.

  • Scripps Research scientist Ilia Droujinine receives over $3 million to reveal the body’s interorgan networks
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    Scripps Research scientist Ilia Droujinine receives over $3 million to reveal the body’s interorgan networks

    The awards from the NIDDK and the LLHF will let Droujinine uncover how interorgan communication goes awry in metabolic disease and aging, paving the way for new treatments.

  • Genetic tracing at the Huanan Seafood market further supports COVID animal origins
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    Genetic tracing at the Huanan Seafood market further supports COVID animal origins

    An international collaboration between Scripps Research, University of Arizona, CNRS and others provides additional analysis of how the pandemic began.

  • Scripps Research scientists expand the genetic alphabet to create new proteins
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    Scripps Research scientists expand the genetic alphabet to create new proteins

    The novel method uses sets of four RNA nucleotides—rather than the natural three—to encode new, synthetic building blocks into proteins.

  • New way to potentially slow cancer growth
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    New way to potentially slow cancer growth

    Using a combination of two protein-mapping methods, Scripps Research scientists uncover novel proteins that could be targeted by future cancer drugs.

  • Gut molecule slows fat burning during fasting
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    Gut molecule slows fat burning during fasting

    Scripps Research scientists discovered a molecule produced by roundworm intestines that signals the brain to slow fat loss when food is not available. 

  • Scripps Research chemists develop new sustainable reaction for creating unique molecular building blocks
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    Scripps Research chemists develop new sustainable reaction for creating unique molecular building blocks

    The building blocks can be used to create polymers with previously unexplored structures and fine-tunable properties, with applications across energy storage and more.

  • Giorgio Quer and Evan Muse
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    New AI tool simplifies heart monitoring: Fewer leads, same accuracy

    Scripps Research scientists showed that, with help from an AI tool, cardiologists can diagnose heart attacks using a simpler, easier and more accessible electrocardiogram technology.

  • Timing matters: Scripps Research study shows ways to improve health alerts
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    Timing matters: Scripps Research study shows ways to improve health alerts

    Wearable health sensors are a powerful tool in disease detection and in stemming the spread of infections.

  • Scripps Research neuroscientist Li Ye named an HHMI Investigator
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    Scripps Research neuroscientist Li Ye named an HHMI Investigator

    This honor from the Howard Hughes Medical Institute recognizes Ye’s “whole-body” approach to studying the how the brain functions in healthy versus diseased states.

  • New sleep study aims to understand cognitive decline in women
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    New sleep study aims to understand cognitive decline in women

    Scripps Research launches digital trial to identify sleep-related risk factors for Alzheimer’s disease and other dementias using activity trackers.

  • Researchers pinpoint brain cells that delay first bite of food
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    Researchers pinpoint brain cells that delay first bite of food

    A set of neurons identified by Scripps Research scientists influence the start of eating and drinking.

  • Researchers identify brain region involved in oxycodone relapse
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    Researchers identify brain region involved in oxycodone relapse

    Study by Scripps Research scientists suggests future therapies for opioid and alcohol addiction.

  • Nine new faculty join Scripps Research
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    Nine new faculty join Scripps Research

    The newly appointed faculty are making transformative discoveries in areas ranging across drug discovery, neuroscience, chemistry, immunity and more.

  • Advancing toward a preventative HIV vaccine
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    Advancing toward a preventative HIV vaccine

    Across four preclinical studies, Scripps Research, IAVI, and additional collaborators make headway in stimulating the rare antibodies needed to fight HIV.

    Jon Steichen
  • Keary Engle Named Dean of Scripps Research’s Skaggs Graduate School of Chemical and Biological Sciences
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    Keary Engle Named Dean of Scripps Research’s Skaggs Graduate School of Chemical and Biological Sciences

    Scripps Research has appointed Professor Keary Engle to the role of Dean of Graduate and Postdoctoral Studies, effective July 1, 2024, and will lead the institute's Skaggs Graduate School of Chemical and Biological Sciences and other education and training programs.

  • A new method for improving checkpoint inhibitor therapy for cancer
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    A new method for improving checkpoint inhibitor therapy for cancer

    Scripps Research scientists found that a “one-two punch” of combining the immunosuppressive drug ruxolitinib with existing checkpoint inhibitor therapies may be a more effective way to fight some cancers, including Hodgkin lymphoma.

  • Neuroscientist Xin Jin granted Pew and McKnight awards
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    Neuroscientist Xin Jin granted Pew and McKnight awards

    Jin is named a 2024 Pew Scholar and receives the McKnight Scholar Award, supporting her research in mapping the genes and cell types in brain development.

  • Esteemed life sciences attorney Barbara Kosacz joins Scripps Research Board of Directors
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    Esteemed life sciences attorney Barbara Kosacz joins Scripps Research Board of Directors

    Scripps Research’s vision to translate basic scientific discovery into effective treatments that benefit human health strikes a chord with Barbara Kosacz, JD—making her addition to the institution’s Board of Directors fitting.

  • Scripps Research’s Skaggs Graduate School awards doctoral degrees to 32nd graduating class
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    Scripps Research’s Skaggs Graduate School awards doctoral degrees to 32nd graduating class

    Skaggs family also honored at commencement ceremony as first recipients of Scripps Research Presidential Medal

  • Scripps Research scientists uncover new molecular drivers of Alzheimer’s
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    Scripps Research scientists uncover new molecular drivers of Alzheimer’s

    By recording detailed electrical and protein measurements of individual brain cells, researchers revealed new potential drug targets for the neurodegenerative disease.

  • Drug-like inhibitor shows promise in preventing flu
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    Drug-like inhibitor shows promise in preventing flu

    Scripps Research scientists have developed a potential drug-like molecule that blocks the first stage of type A influenza infection.

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