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Scripps Research scientists train the immune system to make antibodies against numerous HIV strains
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Scripps Research scientists train the immune system to make antibodies against numerous HIV strains

Joan Pulupa. Credit: Timothy White
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Joan Pulupa joins Scripps Research faculty to study the organization of DNA in brain cells and its links to neurodegeneration

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  • Scripps Research team pioneers an efficient way to stereoselectively add fluorine to drug-like molecules
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    Scripps Research team pioneers an efficient way to stereoselectively add fluorine to drug-like molecules

    A new method uses a novel catalyst and inexpensive fluoride salts to modify the most common chemical bonds—opening doors to new medicines and improved medical imaging.

  • An easier approach to recreate the powerful nerve-blocking molecule found in shellfish
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    An easier approach to recreate the powerful nerve-blocking molecule found in shellfish

    A Scripps Research-led study resolves the challenge of synthesizing saxitoxin, paving the way for new possibilities in pain management.

  • Scientists find cancer weak spot in backup DNA repair system
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    Scientists find cancer weak spot in backup DNA repair system

    New findings from Scripps Research reveal how certain tumors survive DNA damage—and point to a strategy for targeting them.

  • Scripps Research scientists receive $1.1 million to advance AI modeling for HIV vaccine development
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    Scripps Research scientists receive $1.1 million to advance AI modeling for HIV vaccine development

    New AI system helps scientists rapidly pinpoint the most promising paths to an HIV vaccine.

  • Scripps Research study reveals how uterine contractions are regulated by stretch and pressure during childbirth
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    Scripps Research study reveals how uterine contractions are regulated by stretch and pressure during childbirth

    Molecular insights could lead to improved labor and pain treatments.

  • Scripps Research scientists honored on Clarivate’s Highly Cited Researchers list
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    Scripps Research scientists honored on Clarivate’s Highly Cited Researchers list

    The recognized researchers encompass various areas including chemistry, microbiology, immunology, biochemistry and more.

  • Scripps Research team identifies sugar molecules that trigger placental formation
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    Scripps Research team identifies sugar molecules that trigger placental formation

    Study reveals how sugar-protein interactions are critical for the placenta during early pregnancy, shedding light on complications like preeclampsia and restricted fetal growth.

  • Douglas W. Phillips and Steven M. Paul join Scripps Research Board of Directors
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    Douglas W. Phillips and Steven M. Paul join Scripps Research Board of Directors

    Finance and biomedical leaders bring decades of experience in investment strategy and drug development.

  • Scripps Research awarded $6.9 million by NIH to crack the code of lasting HIV vaccine protection
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    Scripps Research awarded $6.9 million by NIH to crack the code of lasting HIV vaccine protection

    The funding will support a multidisciplinary collaboration of four Scripps Research scientists to identify more effective vaccines to treat HIV.

  • Scripps Research scientists launch new digital clinical trial to test repurposed drug for long COVID symptom relief
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    Scripps Research scientists launch new digital clinical trial to test repurposed drug for long COVID symptom relief

    Study will investigate whether a GIP/GLP-1 dual receptor agonist, currently approved for type 2 diabetes, obesity and obstructive sleep apnea, can reduce symptoms of long COVID.

  • Scripps Research professor awarded $3.2 million to advance type 1 diabetes research
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    Scripps Research professor awarded $3.2 million to advance type 1 diabetes research

    Support from the National Institute of Diabetes and Digestive and Kidney Diseases will help reveal how a newly discovered rare cell impacts the autoimmune disease.

  • Scripps Research awarded $4 million to advance platform for neurodevelopmental disorders
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    Scripps Research awarded $4 million to advance platform for neurodevelopmental disorders

    The California Institute for Regenerative Medicine (CIRM) grant supports the development of a new technology designed to restore normal gene function in select neurodevelopmental disorders.

  • Scripps Research-led team receives $14.2M NIH award to map the body’s “hidden sixth sense”
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    Scripps Research-led team receives $14.2M NIH award to map the body’s “hidden sixth sense”

    An NIH-backed effort aims to decode how the nervous system monitors internal organs.

  • Scripps Research discovery could improve type 1 diabetes prevention and treatment
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    Scripps Research discovery could improve type 1 diabetes prevention and treatment

    New findings reveal how specialized cells shield the pancreas from autoimmune attack, providing new therapeutic strategies for type 1 diabetes.

  • Scripps Research scientists unlock new patterns of protein behavior in cell membranes
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    Scripps Research scientists unlock new patterns of protein behavior in cell membranes

    The novel computer method to encode synthetic protein sequences within cell lipid environments offers insights into how membrane proteins fold and function, critical to understanding disease.

  • Former Scripps Research assistant professor awarded 2025 Nobel Prize in Physiology or Medicine
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    Former Scripps Research assistant professor awarded 2025 Nobel Prize in Physiology or Medicine

    Shimon Sakaguchi is honored for his revolutionary discovery of regulatory T cells—revealing how “immune tolerance” impacts autoimmune diseases, cancer and more.

  • Scripps Research associate professor named an HHMI Freeman Hrabowski Scholar
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    Scripps Research associate professor named an HHMI Freeman Hrabowski Scholar

    Associate Professor Xin Jin selected for up to two five-year terms, receiving up to $8.6 million over 10 years to support neuroscience and genomic research.

  • Researchers find brain region that fuels compulsive drinking
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    Researchers find brain region that fuels compulsive drinking

    Study by Scripps Research scientists shows how the brain learns to seek alcohol for relief, not just pleasurable effects, in an animal model.

  • Wearable devices could revolutionize pregnancy monitoring and detect abnormalities
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    Wearable devices could revolutionize pregnancy monitoring and detect abnormalities

    Scripps Research study shows how smartwatch and fitness tracker data align with hormonal changes, offering the potential for early detection of complications.

  • AI model helps boost pandemic preparedness
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    AI model helps boost pandemic preparedness

    Scripps Research breakthrough reduces antibody discovery time from weeks to hours, potentially revolutionizing pandemic response and therapeutic development.

  • Researchers map key human proteins that power coronavirus replication, pointing to new treatment strategies
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    Researchers map key human proteins that power coronavirus replication, pointing to new treatment strategies

    Findings from Scripps Research reveal promising drug targets with potential to block coronaviruses at multiple stages of infection—even across different strains.

  • Researchers identify promising new compound to treat tuberculosis
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    Researchers identify promising new compound to treat tuberculosis

    Study led by Scripps Research, Texas A&M and additional institutions highlights that the world’s deadliest infectious disease needs novel, effective antibiotics.

  • Scientists build an “evolution engine” to rapidly reprogram proteins
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    Scientists build an “evolution engine” to rapidly reprogram proteins

    A new platform developed at Scripps Research enables fast, scalable protein evolution—opening the door to new therapies and diagnostics, and to predicting resistance mutations across many disease areas.

  • Study confirms long-term benefit of implant for blinding eye disease
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    Study confirms long-term benefit of implant for blinding eye disease

    Phase 3 trial results from Scripps Research and collaborators helped support FDA approval of ENCELTO, the first cell-based therapy for a neurodegenerative retinal condition called MacTel.

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