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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • Hidden architecture inside cellular droplets reveals new targets for cancer and neurodegeneration
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    Hidden architecture inside cellular droplets reveals new targets for cancer and neurodegeneration

    Scripps Research scientists discover that some membrane-less compartments are built from tiny filaments—a finding that could shape drug development.

  • Mapping protein production in brain cells yields new insights for brain disease
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    Mapping protein production in brain cells yields new insights for brain disease

    Scripps Research and UC San Diego scientists used a novel method to show that some memory neurons produce proteins at higher rates than others.

  • Calibr-Skaggs and Kainomyx launch collaboration to pioneer novel malaria treatments
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    Calibr-Skaggs and Kainomyx launch collaboration to pioneer novel malaria treatments

    Partnering to speed up the discovery of new malaria drugs that target parasite cytoskeletal pathways, with a focus on global access and affordability.

  • TIME100 Health list features Scripps Research Professor Darrell Irvine
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    TIME100 Health list features Scripps Research Professor Darrell Irvine

    Irvine is recognized for his work in empowering the immune system to fight disease, which includes enhancing vaccines against HIV and cancer. 

  • Fentanyl makeover: Core structural redesign could lead to safer pain medications
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    Fentanyl makeover: Core structural redesign could lead to safer pain medications

    Modified molecule shows diminished respiratory depression—the leading cause of opioid overdose deaths—while retaining full pain-blocking capability.

  • How “invisible” vaccine scaffolding boosts HIV immune response
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    How “invisible” vaccine scaffolding boosts HIV immune response

    Scripps Research scientists designed a DNA scaffold that carries HIV vaccine proteins into the body and sharpens the immune response against the virus.

  • Scientists measure cellular membrane thickness inside cells for the first time
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    Scientists measure cellular membrane thickness inside cells for the first time

    Measuring membrane thickness was previously only possible in artificial membranes—now scientists can do it inside intact cells, providing crucial context for understanding how cells work.

  • Scripps Research study links sleep variability with sleep apnea and hypertension
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    Scripps Research study links sleep variability with sleep apnea and hypertension

    How consumers’ digital activity trackers could enable personalized health screening and early intervention for cardiovascular health and beyond.

  • Study uncovers disrupted brain balance in alcohol dependence
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    Study uncovers disrupted brain balance in alcohol dependence

    Experiments show how dependence on alcohol rewires the brain's "go" and "stop drinking" signaling systems, with implications for preventing relapse.

  • New technique lights up where drugs go in the body, cell by cell
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    New technique lights up where drugs go in the body, cell by cell

    Scripps Research scientists developed a technique that maps drug binding in individual cells throughout the body, potentially explaining side effects and guiding safer drug development.

  • A jolt to the system: Scripps Research biophysicists uncover new electrical transmission in cells
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    A jolt to the system: Scripps Research biophysicists uncover new electrical transmission in cells

    “Tiny biological batteries” can change the cell membrane’s electrical properties—a discovery that has big implications for health, as many essential cellular processes hinge upon precise electrical activity.

  • Study reveals a key hormonal circuit in the kidneys
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    Study reveals a key hormonal circuit in the kidneys

    Scripps Research scientists identify the protein that helps kidney cells regulate renin, providing foundational insight into how kidneys function.

  • Nanoparticle vaccine strategy could protect against Ebola and other deadly filoviruses
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    Nanoparticle vaccine strategy could protect against Ebola and other deadly filoviruses

    Scripps Research scientists turn nanoparticles into virus “showcases” to help the immune system recognize deadly threats.

  • Study reveals high stakes of early immune development—and a potential probiotic fix
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    Study reveals high stakes of early immune development—and a potential probiotic fix

    Scripps Research scientists find that certain gut bacteria are essential for building immune defenses during infancy, pointing to new strategies for protecting children’s health.

  • Scripps Research team pioneers an efficient way to stereoselectively add fluorine to drug-like molecules
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    Scripps Research team pioneers an efficient way to stereoselectively add fluorine to drug-like molecules

    A new method uses a novel catalyst and inexpensive fluoride salts to modify the most common chemical bonds—opening doors to new medicines and improved medical imaging.

  • An easier approach to recreate the powerful nerve-blocking molecule found in shellfish
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    An easier approach to recreate the powerful nerve-blocking molecule found in shellfish

    A Scripps Research-led study resolves the challenge of synthesizing saxitoxin, paving the way for new possibilities in pain management.

  • Scientists find cancer weak spot in backup DNA repair system
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    Scientists find cancer weak spot in backup DNA repair system

    New findings from Scripps Research reveal how certain tumors survive DNA damage—and point to a strategy for targeting them.

  • Scripps Research scientists receive $1.1 million to advance AI modeling for HIV vaccine development
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    Scripps Research scientists receive $1.1 million to advance AI modeling for HIV vaccine development

    New AI system helps scientists rapidly pinpoint the most promising paths to an HIV vaccine.

  • Scripps Research study reveals how uterine contractions are regulated by stretch and pressure during childbirth
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    Scripps Research study reveals how uterine contractions are regulated by stretch and pressure during childbirth

    Molecular insights could lead to improved labor and pain treatments.

  • Scripps Research scientists honored on Clarivate’s Highly Cited Researchers list
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    Scripps Research scientists honored on Clarivate’s Highly Cited Researchers list

    The recognized researchers encompass various areas including chemistry, microbiology, immunology, biochemistry and more.

  • Scripps Research team identifies sugar molecules that trigger placental formation
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    Scripps Research team identifies sugar molecules that trigger placental formation

    Study reveals how sugar-protein interactions are critical for the placenta during early pregnancy, shedding light on complications like preeclampsia and restricted fetal growth.

  • Douglas W. Phillips and Steven M. Paul join Scripps Research Board of Directors
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    Douglas W. Phillips and Steven M. Paul join Scripps Research Board of Directors

    Finance and biomedical leaders bring decades of experience in investment strategy and drug development.

  • Scripps Research awarded $6.9 million by NIH to crack the code of lasting HIV vaccine protection
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    Scripps Research awarded $6.9 million by NIH to crack the code of lasting HIV vaccine protection

    The funding will support a multidisciplinary collaboration of four Scripps Research scientists to identify more effective vaccines to treat HIV.

  • Scripps Research scientists launch new digital clinical trial to test repurposed drug for long COVID symptom relief
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    Scripps Research scientists launch new digital clinical trial to test repurposed drug for long COVID symptom relief

    Study will investigate whether a GIP/GLP-1 dual receptor agonist, currently approved for type 2 diabetes, obesity and obstructive sleep apnea, can reduce symptoms of long COVID.

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