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Scripps Research scientists train the immune system to make antibodies against numerous HIV strains
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Scripps Research scientists train the immune system to make antibodies against numerous HIV strains

Joan Pulupa. Credit: Timothy White
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Joan Pulupa joins Scripps Research faculty to study the organization of DNA in brain cells and its links to neurodegeneration

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  • Scripps Research scientists make annual Highly Cited Researchers list
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    Scripps Research scientists make annual Highly Cited Researchers list

    Featured scientists represent a wide range of fields including chemistry, microbiology, immunology, neuroscience and more

  • Researchers use biophysics to design new vaccines against RSV and related respiratory viruses
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    Researchers use biophysics to design new vaccines against RSV and related respiratory viruses

    Scripps Research scientists improved existing vaccines by analyzing the molecular structure and stability of viral proteins.

  • Professor Benjamin Cravatt and physician-scientist Lou Lange join Scripps Research Board of Directors
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    Professor Benjamin Cravatt and physician-scientist Lou Lange join Scripps Research Board of Directors

    Scripps Research has added Benjamin Cravatt, PhD, professor of Chemistry and the Norton B. Gilula Chair in Biology and Chemistry at Scripps Research, and Lou Lange, MD, PhD, physician-scientist and general partner with Asset Management Ventures, to its Board of Directors.

  • Alzheimer’s and alcohol use disorder share similar gene expression patterns
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    Alzheimer’s and alcohol use disorder share similar gene expression patterns

    By examining RNA in hundreds of thousands of individual brain cells, Scripps Research scientists further support that alcohol use disorder could accelerate Alzheimer’s disease progression, paving the way for future targeted treatments.

  • Calibr-Skaggs announces initial dosing of a first-in-class regenerative lung medicine in a phase 1 trial for idiopathic pulmonary fibrosis
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    Calibr-Skaggs announces initial dosing of a first-in-class regenerative lung medicine in a phase 1 trial for idiopathic pulmonary fibrosis

    CMR316 is a once-weekly inhaled, lung-targeted drug designed to precisely expand lung stem cells and regenerate damaged lung tissue. 

  • Scripps Research advances breakthrough regenerative medicines to reverse aging-related diseases
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    Scripps Research advances breakthrough regenerative medicines to reverse aging-related diseases

    Scientists at Scripps Research and its drug discovery arm, Calibr-Skaggs, develop first-in-class small molecules to repair damaged tissues of the heart, lungs, joints, and more.  

  • “Human mini-brains” reveal autism biology and potential treatments
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    “Human mini-brains” reveal autism biology and potential treatments

    By creating personalized brain “organoids” in the lab, Scripps Research scientists showed how microRNAs impact brain development, and demonstrate how one drug can reverse critical cellular signs of autism.

  • For heavy drinkers, chronic pain associated with alcohol withdrawal could be permanent
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    For heavy drinkers, chronic pain associated with alcohol withdrawal could be permanent

    Scripps Research scientists show that alcohol withdrawal causes long-lasting sensitivity to mechanical stimuli in heavy drinkers, and identify a drug target that could help.

  • Scripps Research scientists discover chemical probes for previously “undruggable” cancer target
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    Scripps Research scientists discover chemical probes for previously “undruggable” cancer target

    Scientists uncover how small molecules interact with a cancer-related protein called FOXA1 and identify a crucial binding site on its surface.

  • CIRM awards more than $28 million to Scripps Research faculty members
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    CIRM awards more than $28 million to Scripps Research faculty members

    The two distinct awards will support collaborative research projects into pollution’s impact on autism as well as risk genes in psychiatric disorders.

  • NIH awards two Scripps Research fellows more than $1 million each for their high-risk, high-impact work
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    NIH awards two Scripps Research fellows more than $1 million each for their high-risk, high-impact work

    Fellows Shannon Miller and Megan Ken have both received NIH Director’s Awards from the NIH Common Fund’s High-Risk, High-Reward Research program.

  • Professor Stuart Lipton awarded $5 million to study the chemical biology of air pollution on the human brain
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    Professor Stuart Lipton awarded $5 million to study the chemical biology of air pollution on the human brain

    The grant from the NIA/NIH will support research into how air pollution could lead to the development of Alzheimer’s disease.

  • Seeing double: Designing drugs that target “twin” cancer proteins
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    Seeing double: Designing drugs that target “twin” cancer proteins

    Scripps Research scientists used knowledge about a protein to characterize drugs that selectively bind to its “twin,” or paralog.

  • Scripps Research scientist Ilia Droujinine receives over $3 million to reveal the body’s interorgan networks
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    Scripps Research scientist Ilia Droujinine receives over $3 million to reveal the body’s interorgan networks

    The awards from the NIDDK and the LLHF will let Droujinine uncover how interorgan communication goes awry in metabolic disease and aging, paving the way for new treatments.

  • Genetic tracing at the Huanan Seafood market further supports COVID animal origins
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    Genetic tracing at the Huanan Seafood market further supports COVID animal origins

    An international collaboration between Scripps Research, University of Arizona, CNRS and others provides additional analysis of how the pandemic began.

  • Scripps Research scientists expand the genetic alphabet to create new proteins
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    Scripps Research scientists expand the genetic alphabet to create new proteins

    The novel method uses sets of four RNA nucleotides—rather than the natural three—to encode new, synthetic building blocks into proteins.

  • New way to potentially slow cancer growth
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    New way to potentially slow cancer growth

    Using a combination of two protein-mapping methods, Scripps Research scientists uncover novel proteins that could be targeted by future cancer drugs.

  • Gut molecule slows fat burning during fasting
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    Gut molecule slows fat burning during fasting

    Scripps Research scientists discovered a molecule produced by roundworm intestines that signals the brain to slow fat loss when food is not available. 

  • Scripps Research chemists develop new sustainable reaction for creating unique molecular building blocks
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    Scripps Research chemists develop new sustainable reaction for creating unique molecular building blocks

    The building blocks can be used to create polymers with previously unexplored structures and fine-tunable properties, with applications across energy storage and more.

  • Giorgio Quer and Evan Muse
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    New AI tool simplifies heart monitoring: Fewer leads, same accuracy

    Scripps Research scientists showed that, with help from an AI tool, cardiologists can diagnose heart attacks using a simpler, easier and more accessible electrocardiogram technology.

  • Timing matters: Scripps Research study shows ways to improve health alerts
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    Timing matters: Scripps Research study shows ways to improve health alerts

    Wearable health sensors are a powerful tool in disease detection and in stemming the spread of infections.

  • Scripps Research neuroscientist Li Ye named an HHMI Investigator
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    Scripps Research neuroscientist Li Ye named an HHMI Investigator

    This honor from the Howard Hughes Medical Institute recognizes Ye’s “whole-body” approach to studying the how the brain functions in healthy versus diseased states.

  • New sleep study aims to understand cognitive decline in women
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    New sleep study aims to understand cognitive decline in women

    Scripps Research launches digital trial to identify sleep-related risk factors for Alzheimer’s disease and other dementias using activity trackers.

  • Researchers pinpoint brain cells that delay first bite of food
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    Researchers pinpoint brain cells that delay first bite of food

    A set of neurons identified by Scripps Research scientists influence the start of eating and drinking.

Groundbreaking Science.
Life-changing Medicine.