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Scripps Research scientists train the immune system to make antibodies against numerous HIV strains
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Scripps Research scientists train the immune system to make antibodies against numerous HIV strains

Joan Pulupa. Credit: Timothy White
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Joan Pulupa joins Scripps Research faculty to study the organization of DNA in brain cells and its links to neurodegeneration

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    AI model detects hidden diabetes risk by reading glucose spikes

    Scripps Research scientists reveal how wearable sensors and artificial intelligence could transform the way we detect and manage pre-diabetes.

  • Scripps Research awarded $1.7 million by NIH to advance biomedical data integration and AI-powered discovery
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    Scripps Research awarded $1.7 million by NIH to advance biomedical data integration and AI-powered discovery

    The grant from the National Center for Advancing Translational Sciences (NCATS) supports the ongoing development of the Biomedical Data Translator—an open-source resource to accelerate human health insights.

  • Where did RNA come from?
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    Where did RNA come from?

    Origin-of-life scientists from Scripps Research reveal how the sugar ribose may have been selected as one of life’s building blocks.

  • Viome and Scripps Research partner to develop first at-home RNA screening test to prevent colon cancer before it strikes
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    Viome and Scripps Research partner to develop first at-home RNA screening test to prevent colon cancer before it strikes

    First-of-its-kind 1,000-patient clinical study will use RNA-based stool and saliva tests to detect colon polyps — early warning signs of colorectal cancer — before they become cancerous.Study aims to enhance colorectal cancer prevention by identifying polyp molecular signals, offering improved sensitivity over at-home DNA tests, which have limited ability to detect precancerous lesions.

  • Tiny chip speeds up antibody mapping for faster vaccine design
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    Tiny chip speeds up antibody mapping for faster vaccine design

    By analyzing just a drop of blood, this microchip gives researchers quicker-than-ever insight into how a person’s antibodies are interacting with a virus or other pathogen.

  • Two-part vaccine strategy generates a stronger, longer-lasting immune boost against HIV
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    Two-part vaccine strategy generates a stronger, longer-lasting immune boost against HIV

    Scripps Research scientists’ new approach combines two immune-activating molecules known as adjuvants.

  • Calibr-Skaggs doses first patient with switchable CAR-T cell therapy in a phase 1 trial for metastatic breast cancer
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    Calibr-Skaggs doses first patient with switchable CAR-T cell therapy in a phase 1 trial for metastatic breast cancer

    CLBR001 + ABBV-461 is a novel, investigational, two-part, switchable chimeric antigen T cell (sCAR-T) immunotherapy designed to treat solid tumors.

  • FDA approves ENCELTO, a first-of-its-kind eye implant that slows vision loss in rare eye disease
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    FDA approves ENCELTO, a first-of-its-kind eye implant that slows vision loss in rare eye disease

    Cell-based therapy with roots at Scripps Research offers new hope for patients with macular telangiectasia type 2.

  • Females may be more biochemically sensitive to alcohol—long before dependence sets in
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    Females may be more biochemically sensitive to alcohol—long before dependence sets in

    Scripps Research’s insights into sex-based differences in brain chemistry could guide personalized treatment strategies for alcohol use disorder.

  • AI pinpoints new anti-aging drug candidates
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    AI pinpoints new anti-aging drug candidates

    More than 70% of the drugs identified by artificial intelligence extended the lifespan of C. elegans worms.

  • HIV vaccine study uncovers powerful new antibody target
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    HIV vaccine study uncovers powerful new antibody target

    Certain antibodies blocked nearly 70% of HIV strains, including those typically hard to target.

  • Newest building on Scripps Research campus earns LEED gold rating
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    Newest building on Scripps Research campus earns LEED gold rating

    Chi-Huey Wong Laboratories for Biomedical Research recognized for sustainable construction.

  • Scripps Research’s Skaggs Graduate School awards doctoral degrees to 33rd graduating class
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    Scripps Research’s Skaggs Graduate School awards doctoral degrees to 33rd graduating class

    The ceremony represented the largest graduating class since the doctoral program’s inception in 1989.

  • Welch Award Honors 2 Scientists for Innovations in Chemical Biology
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    Welch Award Honors 2 Scientists for Innovations in Chemical Biology

    President and CEO Pete Schultz is honored for expanding the genetic code and the development and application of large scale “diversity-based” approaches to the discovery of novel proteins, drugs and modern materials.

  • Genomic data shows widespread mpox transmission in West Africa prior to 2022 global outbreak
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    Genomic data shows widespread mpox transmission in West Africa prior to 2022 global outbreak

    Researchers show that mpox circulated among humans in Nigeria for eight years before the international outbreak, highlighting the need for improved surveillance.

  • Two HIV vaccine trials show proof of concept for pathway to broadly neutralizing antibodies
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    Two HIV vaccine trials show proof of concept for pathway to broadly neutralizing antibodies

    North American and African clinical trials led by Scripps Research, IAVI and additional collaborators across the U.S. and Africa mark progress toward an effective HIV vaccine.

  • Genome of near-extinct northern white rhino offers hope for reviving the species
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    Genome of near-extinct northern white rhino offers hope for reviving the species

    Breakthrough from Scripps Research, the San Diego Zoo Wildlife Alliance, Max Planck Institute and other collaborators paves way for stem cell-based reproduction.

  • Eric Topol authors book on the science of healthy aging
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    Eric Topol authors book on the science of healthy aging

    Latest book by Scripps Research executive vice president guides readers through medical breakthroughs that are primed to extend healthspan

  • Antibodies that recognize lipids: A new path for HIV vaccines and autoimmune disease treatments
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    Antibodies that recognize lipids: A new path for HIV vaccines and autoimmune disease treatments

    Scripps Research scientists used computer modeling to illustrate how antibodies use fatty molecules known as lipids to recognize the HIV virus.

  • Origin of life twist: New study challenges longstanding hypothesis on how first sugars formed
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    Origin of life twist: New study challenges longstanding hypothesis on how first sugars formed

    Scripps Research and Georgia Institute of Technology scientists’ discovery could help understand how life evolved on Earth and lead to better biofuel production.

  • A repurposed anti-inflammatory drug may help treat alcohol use disorder and related pain
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    A repurposed anti-inflammatory drug may help treat alcohol use disorder and related pain

    Scripps Research scientists find that apremilast, an FDA-approved anti-inflammatory drug, reduced both drinking and pain sensitivity in preclinical models of alcohol use disorder.

  • Empowering antibodies to better activate the immune system
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    Empowering antibodies to better activate the immune system

    Scripps Research scientists discover that a higher ratio of antibodies to viral protein helps engage two specific types of immune cells.

  • Illustration of heart
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    A better way to predict a patient’s risk of coronary artery disease

    Scripps Research scientists developed a model that more accurately identifies patients at risk of coronary artery disease and can inform tailored treatment.

  • The very first structural images of a tuberculosis-fighting virus
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    The very first structural images of a tuberculosis-fighting virus

    New insights from Scripps Research could advance phage therapies for the world’s deadliest bacteria—including drug-resistant strains.

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Life-changing Medicine.