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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • HIV vaccine study uncovers powerful new antibody target
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    HIV vaccine study uncovers powerful new antibody target

    Certain antibodies blocked nearly 70% of HIV strains, including those typically hard to target.

  • Newest building on Scripps Research campus earns LEED gold rating
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    Newest building on Scripps Research campus earns LEED gold rating

    Chi-Huey Wong Laboratories for Biomedical Research recognized for sustainable construction.

  • Scripps Research’s Skaggs Graduate School awards doctoral degrees to 33rd graduating class
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    Scripps Research’s Skaggs Graduate School awards doctoral degrees to 33rd graduating class

    The ceremony represented the largest graduating class since the doctoral program’s inception in 1989.

  • Welch Award Honors 2 Scientists for Innovations in Chemical Biology
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    Welch Award Honors 2 Scientists for Innovations in Chemical Biology

    President and CEO Pete Schultz is honored for expanding the genetic code and the development and application of large scale “diversity-based” approaches to the discovery of novel proteins, drugs and modern materials.

  • Genomic data shows widespread mpox transmission in West Africa prior to 2022 global outbreak
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    Genomic data shows widespread mpox transmission in West Africa prior to 2022 global outbreak

    Researchers show that mpox circulated among humans in Nigeria for eight years before the international outbreak, highlighting the need for improved surveillance.

  • Two HIV vaccine trials show proof of concept for pathway to broadly neutralizing antibodies
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    Two HIV vaccine trials show proof of concept for pathway to broadly neutralizing antibodies

    North American and African clinical trials led by Scripps Research, IAVI and additional collaborators across the U.S. and Africa mark progress toward an effective HIV vaccine.

  • Genome of near-extinct northern white rhino offers hope for reviving the species
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    Genome of near-extinct northern white rhino offers hope for reviving the species

    Breakthrough from Scripps Research, the San Diego Zoo Wildlife Alliance, Max Planck Institute and other collaborators paves way for stem cell-based reproduction.

  • Eric Topol authors book on the science of healthy aging
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    Eric Topol authors book on the science of healthy aging

    Latest book by Scripps Research executive vice president guides readers through medical breakthroughs that are primed to extend healthspan

  • Antibodies that recognize lipids: A new path for HIV vaccines and autoimmune disease treatments
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    Antibodies that recognize lipids: A new path for HIV vaccines and autoimmune disease treatments

    Scripps Research scientists used computer modeling to illustrate how antibodies use fatty molecules known as lipids to recognize the HIV virus.

  • Origin of life twist: New study challenges longstanding hypothesis on how first sugars formed
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    Origin of life twist: New study challenges longstanding hypothesis on how first sugars formed

    Scripps Research and Georgia Institute of Technology scientists’ discovery could help understand how life evolved on Earth and lead to better biofuel production.

  • A repurposed anti-inflammatory drug may help treat alcohol use disorder and related pain
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    A repurposed anti-inflammatory drug may help treat alcohol use disorder and related pain

    Scripps Research scientists find that apremilast, an FDA-approved anti-inflammatory drug, reduced both drinking and pain sensitivity in preclinical models of alcohol use disorder.

  • Empowering antibodies to better activate the immune system
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    Empowering antibodies to better activate the immune system

    Scripps Research scientists discover that a higher ratio of antibodies to viral protein helps engage two specific types of immune cells.

  • Illustration of heart
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    A better way to predict a patient’s risk of coronary artery disease

    Scripps Research scientists developed a model that more accurately identifies patients at risk of coronary artery disease and can inform tailored treatment.

  • The very first structural images of a tuberculosis-fighting virus
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    The very first structural images of a tuberculosis-fighting virus

    New insights from Scripps Research could advance phage therapies for the world’s deadliest bacteria—including drug-resistant strains.

  • FDA clears IND for clinical trial testing switchable CAR-T therapy in patients with autoimmune diseases, without chemotherapy
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    FDA clears IND for clinical trial testing switchable CAR-T therapy in patients with autoimmune diseases, without chemotherapy

    Innovative cellular therapy has potential to treat patients with lupus, systemic sclerosis, myositis and RA without chemotherapy-induced immune suppression.

  • A gentle approach offers new hope for inflammatory lung diseases
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    A gentle approach offers new hope for inflammatory lung diseases

    Scripps Research and aTyr Pharma scientists have revealed how the protein HARSWHEP calms inflammation associated with sarcoidosis.

  • How microRNAs act as a “blueprint” for the developing brain
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    How microRNAs act as a “blueprint” for the developing brain

    Scripps Research scientists reveal that microRNAs guide the development of Purkinje cells, a rare type of neuron linked to neurodevelopmental disorders.

  • Enzyme engineering opens door to novel therapies for Parkinson’s, cancers and other hard-to-target protein diseases
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    Enzyme engineering opens door to novel therapies for Parkinson’s, cancers and other hard-to-target protein diseases

    Researchers reprogrammed a botulinum toxin protease to selectively break down disease-causing proteins in human cells, providing proof of concept for developing new therapies for a wide range of illnesses.

  • ‘Low-sugar’ vaccine can provide broad immunity against coronavirus variants
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    ‘Low-sugar’ vaccine can provide broad immunity against coronavirus variants

    Scripps Research chemistry professor Chi-Huey Wong presents results from his team’s studies at the ACS Spring 2025 Digital Meeting.

  • How scientists uncovered memory’s hidden architecture
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    How scientists uncovered memory’s hidden architecture

    New structural hallmarks of memory storage discovered by Scripps Research could lead to treatments for memory loss.

  • Compound found in common herbs inspires potential anti-inflammatory drug for Alzheimer’s disease
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    Compound found in common herbs inspires potential anti-inflammatory drug for Alzheimer’s disease

    Scripps Research scientists created a stable form of carnosic acid, observing greater memory function and other disease improvements in mice.

  • How a crucial DNA repair protein works—and what it means for cancer treatment
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    How a crucial DNA repair protein works—and what it means for cancer treatment

    New structural blueprint is key for better targeting cancer cells, particularly those with BRCA1 and 2 mutations.

  • How air pollution and wildfire smoke may contribute to memory loss in Alzheimer’s disease
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    How air pollution and wildfire smoke may contribute to memory loss in Alzheimer’s disease

    Scripps Research scientists discovered how a chemical modification of a key brain protein—potentially triggered by climate change-induced air pollution, pesticides, wildfires and processed meats—disrupts normal brain cell function.

  • Scripps Research assistant professor receives American Diabetes Association award
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    Scripps Research assistant professor receives American Diabetes Association award

    ADA’s $1.3 million grant will support the Droujinine lab’s research of interorgan dialogue to develop therapeutics for diabetes management.

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