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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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    Scientists discover possible master switch for programming cancer immunotherapy

    Researchers report the discovery that a protein called “Runx3” programs killer T cells to establish residence in tumors and infection sites.

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    Potential New Autism Drug Shows Promise in Mice

    “This drug candidate is poised to go into clinical trials, and we think it might be effective against multiple forms of autism."

  • News

    Ozanimod Successful in Clinical Trials for Multiple Sclerosis

    "The success of ozanimod shows that academia and the NIH can make transforming discoveries that benefit patients and those that care for them."

  • Researchers Discover Promising New Anticancer Strategy
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    Researchers Discover Promising New Anticancer Strategy

    Scientists at Scripps Research have discovered a compound that in laboratory tests irreversibly stops the growth of certain aggressive, treatment-resistant tumor cells.

  • Scientists Find Potential “Missing Link” in Chemistry That Led to Life on Earth
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    Scientists Find Potential “Missing Link” in Chemistry That Led to Life on Earth

    "It’s certainly plausible that such compounds were present on the early Earth and played a role in the emergence of the complex molecules of life."

  • News

    Researchers Find Protein that Could Help Fight Antibiotic Resistance

    Bacterial growth on medical devices—such as artificial hip implants, knee implants and catheters—are a major threat to patient health.

  • How Flu Shot Manufacturing Forces Influenza to Mutate
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    How Flu Shot Manufacturing Forces Influenza to Mutate

    The new study shows exactly why egg-based manufacturing is a problem for the H3N2 influenza subtype.

  • New ResearchKit App from Scripps Research Looks at How Genetic Risk Influences Heart Health Decisions
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    New ResearchKit App from Scripps Research Looks at How Genetic Risk Influences Heart Health Decisions

    MyGeneRank app allows individuals with genetic data from 23andMe to obtain an estimated genetic risk score for coronary artery disease.

  • News

    New Study: ‘Double Decker’ Antibody Technology Fights Cancer

    “Our new ADCs are built something like a double-decker bus..."

  • News

    New Research Opens the Door to ‘Functional Cure’ for HIV

    Scientists have for the first time shown that a novel compound effectively suppresses production of the virus in chronically infected cells.

  • Benjamin Cravatt Elected to National Academy of Medicine
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    Benjamin Cravatt Elected to National Academy of Medicine

    Election to the Academy is considered one of the highest honors in the fields of health and medicine.

  • News

    Scripps Florida Scientists Unveil ‘Roadmap’ to Aid Osteoporosis Treatment Development

    "Because of our aging population, these kinds of therapeutics are in great demand..."

  • News

    New Study Demonstrates Importance of Studying Sleep and Eating in Tandem

    A fascinating new look at fruit fly behavior.

  • Chemists Use Modified DNA Nucleotides to Create New Materials
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    Chemists Use Modified DNA Nucleotides to Create New Materials

    Chemists at Scripps Research have demonstrated that they can repurpose DNA to create new substances with possible medical applications.

  • HIVE Center Receives $27 Million in NIGMS Funding to Advance HIV Research
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    HIVE Center Receives $27 Million in NIGMS Funding to Advance HIV Research

    The center includes scientists from both the California and Florida campuses of Scripps Research.

  • News

    Institute Researchers Join National Digital Health Informatics Collaborative

    Informatics experts at Scripps Research have been awarded close to $3 million as part of a five-year cooperative agreement to launch the National Center for Data to Health (CD2H).

  • A New Approach to Cancer Drug Discovery
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    A New Approach to Cancer Drug Discovery

    "This new approach shows promise for identifying previously unrecognized ‘druggable’ targets in cancers that lack effective treatments."

  • News

    Researchers Explore Ways That a Drug Like Avandia Can Be Made Safer

    The insights could help researchers design new drugs with better efficacy and fewer side effects.

  • Scientists Develop Broad-Spectrum Inhibitors of Influenza Viruses
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    Scientists Develop Broad-Spectrum Inhibitors of Influenza Viruses

    A team of researchers from Scripps Research and Janssen Pharmaceuticals has devised artificial peptide molecules that neutralize a broad range of influenza virus strains.

  • News

    Researchers Get a Lead on How to Detect Degenerative Neurological Diseases Sooner

    A new peptide probe may hold the key to better understanding amyloid diseases.

  • Scripps Florida Scientist Awarded $2.5 Million Collaborative Grant to Develop New Diabetes Treatment
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    Scripps Florida Scientist Awarded $2.5 Million Collaborative Grant to Develop New Diabetes Treatment

    Patrick R. Griffin, co-chair of the Department of Molecular Medicine on the Florida campus of Scripps Research, has been awarded a $2.5 million collaborative grant with Brigham and Women’s Hospital.

  • News

    Calibr and TSRI Executive Matt Tremblay Receives Biocom Catalyst Award

    "Matt’s scientific contributions and business leadership played an important role in establishing Calibr and creating the new model for translational research and innovation represented by the affiliation with TSRI."

    Awards & Honors Matt Tremblay
  • News

    Scripps Research Study Reveals New Clues to How a Successful HIV Vaccine Could Work

    Sugar molecules on HIV envelope protein are likely target for future candidate vaccines.

  • Outside-In Reprogramming: Antibody Study Suggests a Better Way to Make Stem Cells
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    Outside-In Reprogramming: Antibody Study Suggests a Better Way to Make Stem Cells

    Scientists at Scripps Research have found a new approach to the “reprogramming” of ordinary adult cells into stem cells.

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