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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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    Scripps Translational Science Institute, Nature Research launch open-access digital medicine journal

    The editors-in-chief of npj Digital Medicine are Eric Topol, MD, a TSRI professor and the director of STSI, and Steven Steinhubl, MD, STSI’s director of Digital Medicine.

  • News

    News Release

    A study from the lab of biologist Mark Sundrud, Ph.D., has shown that genetics plays a role for some people with Crohn's disease.

  • TSRI scientists discover workings of first promising Marburg virus treatment
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    TSRI scientists discover workings of first promising Marburg virus treatment

    New study reveals key differences between Marburg and Ebola viruses.

  • Novel regenerative drug for osteoarthritis entering clinical trials
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    Novel regenerative drug for osteoarthritis entering clinical trials

    Known as KA34, the drug is a small molecule that “encourages adult stem cells already residing in the joint to mature toward chondrocytes, the cells that produce and maintain healthy cartilage..."

  • News

    Philogen and The Scripps Research Institute announce research collaboration in the field of DNA-Encoded Chemistry

    “We are extremely pleased to collaborate with Prof. Richard Lerner, a great scientist and innovator, and The Scripps Research Institute..."

  • Chemists discover plausible recipe for early life on Earth
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    Chemists discover plausible recipe for early life on Earth

    Chemists have developed a fascinating new theory for how life on Earth may have begun.

  • New structure of key protein holds clues for better drug design
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    New structure of key protein holds clues for better drug design

    “This basic knowledge is potentially helpful for improving drug design,” says Nobel laureate Kurt Wüthrich.

  • Researchers get first complete look at protein behind sense of touch
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    Researchers get first complete look at protein behind sense of touch

    The findings point the way to targeting diseases where this protein is mutated, such as dehydrated hereditary stomatocytosis and congenital lymphedema.

  • The Scripps Research Institute appoints Anna-Marie Rooney as VP of Communications
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    The Scripps Research Institute appoints Anna-Marie Rooney as VP of Communications

    "Anna-Marie is the consummate communicator in biomedicine, a rarified talent."

  • Eric Topol named executive vice president at The Scripps Research Institute
    News

    Eric Topol named executive vice president at The Scripps Research Institute

    "Eric is an esteemed colleague with a clear vision for integrating scientific discovery and translational medicine."

  • News

    New study sheds light on brain changes facilitating cocaine addiction

    Distinct sources of serotonin control different stages of cocaine use

  • News

    ‘Simple, but powerful’ model reveals mechanisms behind neuron development

    New insights into the regulatory network that brain cells use to control neuron growth.

  • Jeffery Kelly Elected to National Academy of Inventors
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    Jeffery Kelly Elected to National Academy of Inventors

    Kelly’s curiosity-driven, fundamental research in chemistry and biology, has led to insights into the principles of protein folding.

  • News

    Blueprints for anti-cancer drugs discovered in bacterial genomes

    “This points the way toward a new therapeutic opportunity,” says lead investigator Ben Shen.

  • Taurine lends hand to repair cells damaged in multiple sclerosis
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    Taurine lends hand to repair cells damaged in multiple sclerosis

    “This could be something to add to an MS therapeutic regime," says Luke Lairson, Ph.D.

  • The structure of cool
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    The structure of cool

    Researchers discover the unexpected atomic structure of cold and menthol sensor TRPM8.

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  • Scientists Create First Semi-Synthetic Organism that Stores and Retrieves Unnatural Information
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    Scientists Create First Semi-Synthetic Organism that Stores and Retrieves Unnatural Information

    A Scripps Research team has designed a bacterium with two unnatural bases, called X and Y, which could someday help them produce new molecules for medical therapies.

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    New Chemistry Method Simplifies Late-Stage Modification of Drug Compounds

    "One can use this new technology to modify a drug molecule at a late stage of synthesis..."

  • News

    Good Cells Gone Bad

    A new study is the first to show precisely how a process in nerve cells called the S-nitrosylation (SNO) reaction may contribute to Parkinson’s disease.

  • News

    New Findings to Help HIV Scientists Establish ‘Template’ for Potent Antibodies

    "Uncovering the process by which neutralizing antibodies develop is critical to HIV vaccine design."

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    To forget or to remember? Memory depends on subtle brain signals, scientists find

    Understanding how brains actively erase memories may open new understanding of memory loss and aging, and open the possibility of new treatments for neurodegenerative disease.

  • News

    New Painkillers Reduce Overdose Risk

    Ninety-one Americans die every day from opioid overdoses—deaths caused when opiates like oxycontin, heroin and fentanyl slow and eventually stop a person’s breathing.

  • A Structural Clue to Attacking Malaria’s ‘Achilles Heel’
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    A Structural Clue to Attacking Malaria’s ‘Achilles Heel’

    Scripps Research and PATH collaboration provides blueprint for design of a next-generation vaccine.

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