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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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    Estrogen-mimicking compounds in foods may reduce effectiveness of breast cancer treatment

  • News

    New TSRI research points to better way to treat depression

    "We need to know what is happening in the brain so that we can develop more efficient therapies."

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    Graduate program at The Scripps Research Institute earns another top ten ranking

    This is the 19th year in a row that the program has earned top ten honors.

  • Long thought to only cause a rare disease, this mutation may ward off malaria
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    Long thought to only cause a rare disease, this mutation may ward off malaria

    A surprising common mutation may have evolved to protect humans from malaria.

  • News

    Cells stressed out? Make mitochondria longer

    Researchers have discovered a pathway in cells that promotes mitochondrial function during times of stress, a response that can guard against disease as we age.

  • News

    Calibr’s repurposed drug to treat non-viral diarrhea enters into a clinical trial

    Calibr has now identified and repurposed an FDA-approved drug, clofazimine, used for decades to treat leprosy, as a potential new treatment for cryptosporidiosis.

  • A new cross-coupling simplifies the synthesis of drug-like molecules
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    A new cross-coupling simplifies the synthesis of drug-like molecules

    "It’s already clear that this method opens the door to creating new types of compounds and new types of bonds."

  • TSRI scientists zero in on treatment for Charcot-Marie-Tooth disease
    News

    TSRI scientists zero in on treatment for Charcot-Marie-Tooth disease

    "This study provides guidance for developing therapeutics," says Xiang-Lei Yang, PhD, TSRI professor and senior author of the study.

  • TSRI researchers uncover culprit in Parkinson’s brain cell die-off
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    TSRI researchers uncover culprit in Parkinson’s brain cell die-off

    The new study offers an explanation for why neurons die off in the first place.

  • Next-generation arthritis treatments could benefit both horses and humans
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    Next-generation arthritis treatments could benefit both horses and humans

    More than 27 million people live with osteoarthritis, and it turns out, elite racing and jumping horses do, too.

  • New TSRI method accelerates studies on carbohydrate biology
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    New TSRI method accelerates studies on carbohydrate biology

    The breakthrough may expand research on the roles of glycans in human diseases, including cancers.

  • News

    Decoding the genome’s dark matter

    By combing through thousands of human genome sequences, scientists have identified regions of our DNA that rarely change.

  • News

    Cross-bred flies reveal new clues about how proteins are regulated

    Scientists are finding new clues about how proteins interact with each other.

  • News

    TSRI stroke drug demonstrates safety in clinical trial

    "These results lay the groundwork for the next steps toward FDA approval."

  • News

    ‘Click chemistry’ reactions may boost cancer-fighting drug potency

    Researchers have developed a quick and easy way to simultaneously modify dozens of drugs or molecules to improve their disease-fighting properties.

  • Video: Researchers bring scattered data together
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    Video: Researchers bring scattered data together

    Scientists at The Scripps Research Institute are leading the charge to make scientific data more accessible.

  • TSRI scientists receive $15 million to study viral outbreak survivors
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    TSRI scientists receive $15 million to study viral outbreak survivors

    Data from individual patients could hold clues to stopping Ebola virus and related killers.

  • Scientists find key proteins control risk of osteoarthritis during aging
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    Scientists find key proteins control risk of osteoarthritis during aging

    The proteins appear to be responsible for the maintenance of healthy cells in the cartilage of our joints.

  • News

    Heroin vaccine blocks lethal overdose

    "The heroin vaccine is one step closer to clinical evaluation," says Candy S. Hwang, PhD, first author of the study and a research associate at TSRI.

  • Microscopic chariots deliver molecules within our cells
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    Microscopic chariots deliver molecules within our cells

    Researchers provide critical insight into cellular cargo transport machinery linked to neurological disorders.

  • TSRI scientists take big step toward stopping cancer metastasis
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    TSRI scientists take big step toward stopping cancer metastasis

    New research uncovers how levels of a key protein can spark cancer spread.

  • TSRI receives $10 million grant to study effects of alcohol on the brain
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    TSRI receives $10 million grant to study effects of alcohol on the brain

  • TSRI researchers identify gene responsible for mesenchymal stem cells’ stem-ness’
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    TSRI researchers identify gene responsible for mesenchymal stem cells’ stem-ness’

    A new study provides insight into how mesenchymal stem cells should be studied for clinical purposes.

  • Skaggs family makes “transformational” lead gift toward  The Scripps Research Institute’s Graduate Program endowment
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    Skaggs family makes “transformational” lead gift toward The Scripps Research Institute’s Graduate Program endowment

    In recognition of this gift, the program will be renamed the Skaggs Graduate School of Chemical and Biological Sciences. 

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