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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • Scripps Research team awarded $2 million to study brain circuitry driving alcohol dependence
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    Scripps Research team awarded $2 million to study brain circuitry driving alcohol dependence

    Neuroscientist Candice Contet and colleagues to take a close look how an understudied brain region promotes alcohol drinking.

  • Doctors may be able to enlist a mysterious enzyme to stop internal bleeding
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    Doctors may be able to enlist a mysterious enzyme to stop internal bleeding

    "This opens up new options for treating diseases of the blood."

  • News

    Scripps Research scientists uncover unexpected role for two proteins as immune system regulators

    An unexpected discovery in two disease-linked proteins could shed light on human immune system disorders, including a rare and often fatal childhood disease.

  • Ebola virus experts discover powerful, new approach for future therapeutics
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    Ebola virus experts discover powerful, new approach for future therapeutics

    This landmark study is the first-ever side-by-side comparison of 171 antibodies against Ebola virus.

  • Best of both worlds: Combining two skeleton-building chemical reactions provides powerful tool for building new drugs
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    Best of both worlds: Combining two skeleton-building chemical reactions provides powerful tool for building new drugs

    Scripps Research scientists have developed a powerful new strategy for synthesizing molecular skeletons of chemicals used in drugs and other important products

  • Researchers look to worms for a new model of a peripheral nervous system disease
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    Researchers look to worms for a new model of a peripheral nervous system disease

    Scientists have discovered that a microscopic roundworm develops similar nerve damage to human patients when their muscle cells are genetically engineered to produce TTR proteins.

  • New antibody analysis accelerates rational vaccine design
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    New antibody analysis accelerates rational vaccine design

    "We can now watch antibody responses evolve almost in real time."

  • Scripps Research and Bristol-Myers Squibb scientists create atomic glue gun to build better nucleic acid therapeutics
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    Scripps Research and Bristol-Myers Squibb scientists create atomic glue gun to build better nucleic acid therapeutics

    New method for precisely controlling 3D architecture of critical linkages used in potential therapeutics.

  • New strategy for cancer therapy spells double trouble for tumors
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    New strategy for cancer therapy spells double trouble for tumors

    "This could give us a way to kill tumors without harming normal cells..."

  • Scientists get first look at T cell responses in Ebola virus survivors
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    Scientists get first look at T cell responses in Ebola virus survivors

    New Scripps Research study offers guidance for more effective Ebola vaccines.

  • Keary Engle receives Bristol-Myers Squibb award
    News

    Keary Engle receives Bristol-Myers Squibb award

    The $75,000 in award funding will support Engle’s work to invent new tools to make new drug candidates quickly, efficiently and sustainably.

  • The Scripps Research Institute expands faculty with five new members
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    The Scripps Research Institute expands faculty with five new members

    "We’re very pleased to have these stellar scientists join our faculty."

  • Mobile health devices diagnose hidden heart condition in at-risk populations
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    Mobile health devices diagnose hidden heart condition in at-risk populations

    "Our study shows an almost threefold improvement in the rate of diagnosis of AFib in the those actively monitored compared to usual care."

  • Mobile health technologies accurately measure new cardiovascular ‘vital signs’
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    Mobile health technologies accurately measure new cardiovascular ‘vital signs’

    There's new evidence that cardiovascular risk factors can be accurately measured and tracked independently outside of a physician’s office using new mobile health technologies.

    Steven Steinhubl
  • A well-known animal health drug could stop outbreaks of malaria and Zika virus
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    A well-known animal health drug could stop outbreaks of malaria and Zika virus

    The researchers estimated that a single human dose of the drugs would convey an insecticide effect against mosquitos and sand flies lasting 50–90 days.

    Calibr-Skaggs Matt Tremblay
  • Some existing anti-cancer drugs may act in part by targeting RNA, study shows
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    Some existing anti-cancer drugs may act in part by targeting RNA, study shows

    The research offers another approach for tackling diseases that have been considered “undruggable,” including ALS, muscular dystrophy, cystic fibrosis and certain cancers.

  • 2019 Priestley Medal goes to K. Barry Sharpless
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    2019 Priestley Medal goes to K. Barry Sharpless

    "Dr. Sharpless has made numerous contributions to chemistry that have each significantly moved the field forward."

  • Scripps Research scientists find new way to block alcohol addiction and ease withdrawal
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    Scripps Research scientists find new way to block alcohol addiction and ease withdrawal

    "The big takeaway here is that we have a new molecular target linked to alcohol addiction."

  • AbbVie and Calibr announce collaboration for next generation T-cell therapies
    News

    AbbVie and Calibr announce collaboration for next generation T-cell therapies

    Collaboration will focus on switchable CAR-T therapies aimed primarily at solid tumors.

  • Scripps Research study provides new clues to improving chemotherapies
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    Scripps Research study provides new clues to improving chemotherapies

    The work has important implications for understanding how human cancer cells develop resistance to natural product-based chemotherapies. 

  • Scientists find potential disease-fighting ‘warheads’ hidden in bacteria
    News

    Scientists find potential disease-fighting ‘warheads’ hidden in bacteria

    Bacteria found in soil may harbor a potential game-changer for drug design. 

  • Chemists achieve major milestone of synthesis: remote chiral induction
    News

    Chemists achieve major milestone of synthesis: remote chiral induction

    The method is likely to be adopted widely for the making of prospective drugs and other chemical products.

  • Scripps Research chemists design ‘miniecosystems’ to test drug function
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    Scripps Research chemists design ‘miniecosystems’ to test drug function

    Scripps Research scientists have solved a major problem in chemistry and drug development by using droplet-sized ‘miniecosystems’ to quickly see if a molecule can function as a potential therapeutic.

  • Researchers uncover new ‘proofreading’ mechanism in gene translation
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    Researchers uncover new ‘proofreading’ mechanism in gene translation

    The team found that when the protein that controls the process is defective, in nerve cells in particular, it can allow dangerous, misfolded proteins to accumulate.

Groundbreaking Science.
Life-changing Medicine.