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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • FDA to consider Scripps Research drug ozanimod for treatment of multiple sclerosis
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    FDA to consider Scripps Research drug ozanimod for treatment of multiple sclerosis

    The U.S. Food and Drug Administration (FDA) has accepted a New Drug Application for ozanimod, a potential treatment for multiple sclerosis that was created at Scripps Research.

  • Jeanne Loring named ‘Stem Cell Pioneer of the Year’ in inaugural Xconomy Awards
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    Jeanne Loring named ‘Stem Cell Pioneer of the Year’ in inaugural Xconomy Awards

    Loring, a genomics researcher and professor emeritus at Scripps Research, is also founding director of the institute’s Center for Regenerative Medicine.

  • An influenza virus mutation could be the secret to better egg-based seasonal vaccines
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    An influenza virus mutation could be the secret to better egg-based seasonal vaccines

    Preparing a seasonal flu vaccine with the G186V mutation may prevent a vexing problem that commonly occurs during the vaccine manufacturing process.

  • New immunotherapy insights: Killer T cells that amplify immune response to viral infections may be a key to better cancer drugs
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    New immunotherapy insights: Killer T cells that amplify immune response to viral infections may be a key to better cancer drugs

    Scripps Research scientists discover a mechanism for boosting the body's production of self-renewing T cells, offering a potential new pathway for enhancing cancer immunotherapy.

  • Scripps Research scientists reveal exceptional structural detail of novel protein family involved in sour taste reception and prevalent in digestive and immune systems
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    Scripps Research scientists reveal exceptional structural detail of novel protein family involved in sour taste reception and prevalent in digestive and immune systems

    Using cryogenic electron microscopy, researchers gained crucial structural and functional insights into proton channels involved in balance, taste and yet-unidentified roles in human health.

  • Prescription drug costs steadily soar, yet price transparency is lacking
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    Prescription drug costs steadily soar, yet price transparency is lacking

    Scripps Research analyzed pharmacy insurance claims from over 35 million Americans, finding ‘continual, marked, annual increases’ of popular brand-name drugs.

  • Discovery of bacteria’s protein quality control agent offers insight into origins of life
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    Discovery of bacteria’s protein quality control agent offers insight into origins of life

    Soon after cells invented protein assembly, they faced another task crucial to survival: Disposing of incomplete protein fragments. Claudio Joazeiro, PhD, uncovers how bacteria and archaea handle recycling.

  • Calibr names drug development veteran Pamela Garzone as chief medical officer
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    Calibr names drug development veteran Pamela Garzone as chief medical officer

    Garzone, an industry leader in translational research and clinical development, fills a critical leadership role as several of Calibr’s portfolio programs advance toward the clinic.

  • Monkey-infecting virus may provide part of future HIV vaccine
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    Monkey-infecting virus may provide part of future HIV vaccine

    A protein from Simian Immunodeficiency Virus (SIV), which can infect monkeys and apes, has shown promise as a potential component of a vaccine against HIV. 

  • Forget what the textbooks say, human ‘natural killer’ cells do remember past viral attacks
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    Forget what the textbooks say, human ‘natural killer’ cells do remember past viral attacks

    Scientists at Scripps Research have discovered that the immune system’s “natural killer” cells can actually remember old enemies, allowing them to better identify threats and hone their attack.

  • Scripps Research ranked second in the world among scientific institutes for biomedical research
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    Scripps Research ranked second in the world among scientific institutes for biomedical research

    Nature Index has ranked Scripps Research second in the world and first in the United States among stand-alone scientific institutes for biomedical research.

  • Scripps Research awards doctorates to largest graduating class in institute’s history
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    Scripps Research awards doctorates to largest graduating class in institute’s history

    Skaggs Graduate School of Chemical and Biological Sciences recognizes 50+ graduate students, the largest class in the school’s history, on May 17.

  • News

    FDA approves phase 1/2 clinical trial with ABX196 in patients with liver cancer

    The U.S. Food and Drug Administration has approved an investigational new drug (IND) application for a phase 1/2 clinical trial of ABX196, a liver cancer therapy developed at Scripps Research.

  • Unexplored neural circuit modulates memory strength
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    Unexplored neural circuit modulates memory strength

    A group of dopamine-producing neurons called PPL2 turns the volume up or down on aversive memories in the fly brain, studies from the Tomchik lab show.

  • Nanotubes enable travel of Huntington’s disease protein
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    Nanotubes enable travel of Huntington’s disease protein

    Nanotube tunnels built with the help of the Rhes protein serve as bridges for the toxic Huntington’s disease protein, a new study finds.

    Neuroscience Srinivasa Subramaniam
  • Chemist Keary Engle receives Dreyfus Foundation Teacher-Scholar Award
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    Chemist Keary Engle receives Dreyfus Foundation Teacher-Scholar Award

    Engle joins select group of early career faculty from nation’s top institutes to receive an unrestricted research grant of $100,000.

  • Chemical biologist Benjamin Cravatt of Scripps Research wins prestigious Royal Society of Chemistry award
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    Chemical biologist Benjamin Cravatt of Scripps Research wins prestigious Royal Society of Chemistry award

    Cravatt is recognized for pioneering a powerful new approach for identifying protein classes based on their activity, vastly expanding the possibilities of small-molecule drug discovery.

  • Scripps Research spinoff Abide Therapeutics to be acquired by Danish pharma company Lundbeck
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    Scripps Research spinoff Abide Therapeutics to be acquired by Danish pharma company Lundbeck

    Abide Therapeutics, Inc., a clinical-stage biopharmaceutical company founded by Scripps Research professors Benjamin Cravatt, PhD, and Dale Boger, PhD, will be acquired by the Danish pharmaceutical firm H. Lundbeck A/S (Lundbeck).

  • FDA approves Scripps Research-originated drug tafamidis for cardiomyopathy
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    FDA approves Scripps Research-originated drug tafamidis for cardiomyopathy

    The U.S. Food and Drug Administration has approved tafamidis for the treatment of heart disease (cardiomyopathy) caused by mutant or wild-type transthyretin aggregation in adults.

    Evan Powers
  • Scripps Research selects high school summer interns for 15th annual Kenan Fellows program
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    Scripps Research selects high school summer interns for 15th annual Kenan Fellows program

    Eleven students from high schools across Palm Beach County will join biomedical research laboratories at Scripps Research in Jupiter, Florida this summer as part of the institute’s 15th annual high school student internship program.

  • Vaccine shows lasting effects against deadly synthetic opioids
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    Vaccine shows lasting effects against deadly synthetic opioids

    Scientists at Scripps Research have developed an experimental vaccine that may one day help treat addiction to fentanyl, a highly potent opioid linked to an epidemic of overdoses and fatalities in recent years.

  • Gene repair improves memory and seizures in adult autism model
    News

    Gene repair improves memory and seizures in adult autism model

    There may be reason to treat severe neurodevelopmental disorders at any stage of life once options become available, a new study of SYNGAP1 related autism suggests.

  • New ‘POWERMOM’ app launched to study maternal health
    News

    New ‘POWERMOM’ app launched to study maternal health

    Researchers at the Scripps Research Translational Institute have launched a new digital research platform called POWERMOM that enables pregnant women anywhere in the United States to contribute their health information to the study using a smartphone app.

  • Chemist Jin-Quan Yu of Scripps Research elected to American Academy of Arts and Sciences
    News

    Chemist Jin-Quan Yu of Scripps Research elected to American Academy of Arts and Sciences

    The American Academy of Arts and Sciences, one of the world’s most prestigious honor societies, has named Scripps Research chemist Jin-Quan Yu, PhD, as an elected member of its 2019 class. Yu is known globally for his groundbreaking work in the field of organic synthetic chemistry.

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