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Where hypotheses become headlines: Featured coverage of the breakthroughs—and the people—driving our research forward

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The Scripps Research scientists leading the Huang Foundation-supported projects. From left: Terrence Messmer, Sarah Burbach, Matthew Holcomb, Bryan Briney, Stefano Forli, Benjamin Cravatt, Christopher Parker, Andrew Ward and Charles Bowman.
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Scripps Research garners major support for AI innovations in biomedicine with compute grant from Jen-Hsun and Lori Huang Foundation

Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

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  • Society for Neuroscience presents Hollis Cline with lifetime achievement award for exemplary career and mentorship
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    Society for Neuroscience presents Hollis Cline with lifetime achievement award for exemplary career and mentorship

    Cline is honored as an inspiring scientific role model, having trained more than 40 graduate students and postdoctoral scientists in her lab, over half of whom are women.

  • When added to gene therapy, plant-based compound may enable faster, more effective treatments
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    When added to gene therapy, plant-based compound may enable faster, more effective treatments

    Scientists at Scripps Research believe they have found a way to sidestep some of the current difficulties of gene therapy, resulting in a more efficient delivery method that would save money and improve treatment outcomes.

  • Chemists devise efficient synthesis of ginkgo tree compound that could be used as a ‘green’ insecticide
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    Chemists devise efficient synthesis of ginkgo tree compound that could be used as a ‘green’ insecticide

    Chemists at Scripps Research have invented an efficient method for making a synthetic version of the plant compound bilobalide, which holds potential commercial value for medicines and “green” insecticides.

  • Powerful new genomics method can be used to reveal the causes of rare genetic diseases
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    Powerful new genomics method can be used to reveal the causes of rare genetic diseases

    The technique compares activity levels of maternal and paternal alleles across the genome and detects when the activity lies far enough outside the normal range to be a plausible cause of disease.

  • Scientists identify molecule that could have helped cells survive—and thrive—on early Earth
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    Scientists identify molecule that could have helped cells survive—and thrive—on early Earth

    Compounds called cyclophospholipids would have held up against the planet’s harsh conditions, helping the first cells form and proliferate. 

  • New chemical reaction adds to ‘click-chemistry’ family, could speed drug discovery
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    New chemical reaction adds to ‘click-chemistry’ family, could speed drug discovery

    A team including Nobel laureate chemist K. Barry Sharpless, PhD, has discovered an easy, efficient type of chemical reaction that could become widely useful in building potential new drug molecules and other valuable chemical products.

  • New symposium highlights research on targeting incurable diseases via RNA
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    New symposium highlights research on targeting incurable diseases via RNA

    ‘RNA – From Biology to Drug Discovery,’ day-long conference, to be held on the Jupiter, Florida campus of Scripps Research, to focus on translational promise of a novel targeting strategy. 

    Events
  • ‘Relaxed’ enzymes may be at the root of Charcot-Marie-Tooth disease
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    ‘Relaxed’ enzymes may be at the root of Charcot-Marie-Tooth disease

    Scripps Research scientists make a key discovery into the underpinnings of a complex disease that damages patients' peripheral nervous system. 

  • New study reveals Scripps Research, Florida has produced $3 billion worth of economic impact since 2004
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    New study reveals Scripps Research, Florida has produced $3 billion worth of economic impact since 2004

    The launch of the Florida campus of Scripps Research has produced an economic impact of $3 billion since the nonprofit biomedical institute opened an East Coast branch 15 years ago. 

  • Scripps Research professor Peter Vogt honored with Horwitz Prize for key contributions to targeted cancer treatment
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    Scripps Research professor Peter Vogt honored with Horwitz Prize for key contributions to targeted cancer treatment

    Vogt's work led to the discovery of the first oncogene and many other other genetic drivers of cancer. Of the 100-plus Horwitz Prize winners to date, 50 percent have gone on to receive Nobel Prizes. 

  • All shook up: Researchers mix RNA and DNA to study how life’s process began billions of years ago
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    All shook up: Researchers mix RNA and DNA to study how life’s process began billions of years ago

    A hypothesis known as RNA World is a fascinating explanation for how life began, but it may not hold true. The problem is that the ingredients needed to make RNA World work just didn’t exist on early Earth.

  • Scientists find cause of debilitating eye disease
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    Scientists find cause of debilitating eye disease

    A 15-year effort points to treatments to help MacTel patients and offers potential new insights into other eye diseases.

  • Electrochemistry breakthrough simplifies creation of coveted molecules needed for drugs, electronics
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    Electrochemistry breakthrough simplifies creation of coveted molecules needed for drugs, electronics

    A new method for making valuable compounds known as “hindered ethers” significantly improves production yield while reducing expense and reaction steps.

  • Brain cells that suppress drug cravings may be the secret to better addiction medicines
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    Brain cells that suppress drug cravings may be the secret to better addiction medicines

    Rather than continue to dig for clues on what drives relapse among those who struggle with compulsive drug use, a Scripps Research team explored how the brain responds to environmental cues that suppress cravings.

    Neuroscience Nobuyoshi Suto
  • Discovery paves the way for earlier detection of type 1 diabetes
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    Discovery paves the way for earlier detection of type 1 diabetes

    Scientists at Scripps Research have discovered what may be the earliest possible biological marker of type 1 diabetes, formerly known as juvenile diabetes.

  • Discovery of hidden outbreak hints that Zika virus can spread silently
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    Discovery of hidden outbreak hints that Zika virus can spread silently

    A genomics study of travel-associated Zika cases reveals an undiscovered outbreak in Cuba in 2017, underscoring the need for coordinated disease surveillance.

  • Retinal protein-transport discovery may help define new strategies for treating eye disease
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    Retinal protein-transport discovery may help define new strategies for treating eye disease

    A new study reveals how proteins from the eye’s nerve cells relay visual cues to different parts of the brain. 

  • FDA accepts IND application for novel immunotherapeutic for prostate cancer in development by Calibr at Scripps Research
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    FDA accepts IND application for novel immunotherapeutic for prostate cancer in development by Calibr at Scripps Research

    Calibr announced that the U.S. Food and Drug Administration (FDA) has cleared its investigational new drug application for the treatment of metastatic castration-resistant prostate cancer.

  • Discovery of anti-opioid pathway offers new route to designing safer pain medications
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    Discovery of anti-opioid pathway offers new route to designing safer pain medications

    The discovery of GPR139 presents a new target for making safer pain medications. Nematodes helped reveal the genetic network that controls opioid activation of a nervous system.

  • Society of Heterocyclic Chemistry honors Dale Boger with E.C. Taylor Senior Award
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    Society of Heterocyclic Chemistry honors Dale Boger with E.C. Taylor Senior Award

    Dale Boger, PhD, the Richard and Alice Cramer Professor of Chemistry at Scripps Research, has been awarded the E.C. Taylor Senior Award by the International Society of Heterocyclic Chemistry.

  • Scientists discover ‘forgetting’ enzyme that lops brain cell branches
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    Scientists discover ‘forgetting’ enzyme that lops brain cell branches

    The “synapse pruning” process that underlies everyday learning involves a pruning function mediated by an enzyme called caspase 2.

  • Peter Schultz wins Tetrahedron Prize for Creativity in Organic Chemistry
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    Peter Schultz wins Tetrahedron Prize for Creativity in Organic Chemistry

    Scripps Research President and Chief Executive Officer Peter Schultz is recognized for his significant original contributions to the field of organic chemistry.

  • A chemical clue to how life started on Earth
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    A chemical clue to how life started on Earth

    Every living thing on Earth stems from the same limited set of 20 amino acids, and a new study suggests this didn't happen by accident. 

  • Chemist Kim Janda honored with ACS Portoghese Lectureship Award
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    Chemist Kim Janda honored with ACS Portoghese Lectureship Award

    The Medicinal Chemistry Division of ACS, along with the Journal of Medicinal Chemistry, will present Janda with the 2019 Philip S. Portoghese Medicinal Chemistry Lectureship Award to honor his many contributions to medicinal chemistry research.

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