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Response to essay published in Angewandte Chemie.

The drug, developed at Scripps Research, recently gained U.S. and European regulatory approval for the treatment of multiple sclerosis. It is also being studied for Crohn’s disease.

The news comes less than two months after the therapy gained approval from the U.S. Food and Drug Administration. Ozanimod is also in advanced clinical development for moderate-to-severe ulcerative colitis and Crohn’s disease.

In experiments on human 'mini-brains,' the drug preserved nerve connections that are lost to Alzheimer’s. The drug is also being evaluated for COVID-19, as it is known to inhibit viral activity.

How does general anesthesia cause loss of consciousness? Despite its 175-year-history of use by the U.S. medical system, science has been unable to definitively answer that question, until now.

Patapoutian, who made transformative discoveries about proteins that sense pressure, becomes the first Scripps Research scientist to win the Kavli Prize. 

Even though the coronaviruses that cause SARS and COVID-19 are closely related and infect cells the same way, they aren’t cross-protective in cell culture experiments.

The Skaggs Graduate School of Chemical and Biological Sciences awarded doctorates to 44 young scientists who comprise the 28th graduating class at Scripps Research. In lieu of the traditional annual commencement ceremony, a virtual celebration will be held in July.

A hallmark of cancer cells is that they lack contact inhibition, even when crowded. A new study from Kissil lab reveals a protein biologists thought they knew well, YAP, is playing an unexpected role in switching off that normal, healthy response, with input from many players.

Scripps Research, Florida Chemistry Professor Matthew Disney, PhD, has been honored with a prestigious Research Program Award from the National Institute of Neurological Disorders and Stroke (NINDS), to aid Disney’s development of treatments for incurable diseases such as Alzheimer’s, Parkinson’s, ALS and frontotemporal dementia.

The mechanism underlying Parkinson’s dyskinesia has been unknown, until now. An international collaboration led by Scripps Research, Florida has found a key cause, and with it, potentially, a new route to providing relief.

Patapoutian, a professor in Scripps Research’s Department of Neuroscience, has catapulted the scientific understanding of sensory transduction—the methods by which the body responds to sensory input from the eyes, tongue, nose and skin.

Clinical trials are assessing whether the drug can temper the immune system’s response to coronavirus in the lungs, preventing the dangerous inflammation seen in patients with severe disease.

Using some of the most powerful microscopes available to scientists today, structural biologists at Scripps Research have developed a method for examining the machinery of HIV in unprecedented detail.

Once a cancer patient’s tumors develop resistance to chemotherapy, the prognosis can be poor. However, inhibiting a key gene involved in multidrug resistance, MDR1, has not improved outcomes. A new study offers a reason, revealing unintended downstream effects on immune system cells.

An international research network centers around ReFRAME, the world’s leading collection of drugs known to be safe in humans.

In experiments, mice inoculated with virus-mimicking particles showed a stronger antibody response than when inoculated with hepatitis C proteins on their own.

Autism disproportionately affects boys. A new study offers a potential mechanism. Brain cells called microglia prune synaptic connections during early development. A specific genetic mutation affecting males led to enlarged microglia that had trouble performing that job.

An antibody recovered from a survivor of the SARS epidemic in the early 2000s has revealed a potential vulnerability of the coronavirus at the root of COVID-19.

The surprise finding from a Scripps Research team reveals a potential new approach for treating cardiovascular diseases.

Developed collaboratively by several Scripps Research teams, Outbreak.info seeks to bring together research information on a single site and improve data visualization.

IBM's World Community Grid hosts Scripps Research project to virtually screen chemical compounds that might help fight COVID-19.

The immune-modulating therapy is also in advanced clinical development for adults and children with moderate-to-severe ulcerative colitis and Crohn’s disease.