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Where hypotheses become headlines: Featured coverage of the breakthroughs—and the people—driving our research forward

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The Scripps Research scientists leading the Huang Foundation-supported projects. From left: Terrence Messmer, Sarah Burbach, Matthew Holcomb, Bryan Briney, Stefano Forli, Benjamin Cravatt, Christopher Parker, Andrew Ward and Charles Bowman.
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Scripps Research garners major support for AI innovations in biomedicine with compute grant from Jen-Hsun and Lori Huang Foundation

Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

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  • Autism gene study finds widespread impact to brain’s growth signaling network
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    Autism gene study finds widespread impact to brain’s growth signaling network

    A genetic mutation linked to autism causes significant undergrowth of brain tissue. An existing medicine appears to rescue the condition in mouse studies.

    Neuroscience Page Damon
  • Crohn’s disease may develop from warped immune cell signaling during bile acid exposure
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    Crohn’s disease may develop from warped immune cell signaling during bile acid exposure

    Study reveals how T cells in the small intestine respond to bile acids, offering localized treatment direction for a cause of chronic illness.

  • Scientific detective work reveals important clues in case of rare Ebola relapse in Central Africa
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    Scientific detective work reveals important clues in case of rare Ebola relapse in Central Africa

    An international team, including scientists from Scripps Research, helped find answers after a man became sick for a second time with Ebola and sparked a transmission chain of more than 90 cases.

  • Scripps Research mourns the loss of board member and global health leader John C. Martin
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    Scripps Research mourns the loss of board member and global health leader John C. Martin

    Martin, former CEO and executive chairman of Gilead Sciences, made pivotal impacts on global public health over the course of an impressive career spanning science and business.

  • Newly discovered node in the brain could help scientists understand dysfunctional social behavior
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    Newly discovered node in the brain could help scientists understand dysfunctional social behavior

    The findings may lead to a better understanding of social disorders such as autism or depression.

  • B.1.1.7 variant of COVID-19 virus spreading rapidly in United States
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    B.1.1.7 variant of COVID-19 virus spreading rapidly in United States

    A genetic analysis of virus samples suggests that the UK-originating variant, which is 40-50 percent more transmissible, entered the country in late November 2020.

  • Experimental COVID-19 vaccine appears to work well against variants of concern
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    Experimental COVID-19 vaccine appears to work well against variants of concern

    Results from studies in mice suggest the protein-based vaccine could potentially serve as a booster shot to cover emerging COVID-19 variants.

  • Antibody therapies for Parkinson’s and Alzheimer’s may cause harmful inflammation
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    Antibody therapies for Parkinson’s and Alzheimer’s may cause harmful inflammation

    Scientists find evidence that antibody-based treatments in clinical trials for neurodegenerative diseases may trigger an inflammatory response in human brain immune cells, eroding their positive effects.

  • Scripps Research receives inaugural grant from The Conrad Prebys Foundation for scientific research and education
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    Scripps Research receives inaugural grant from The Conrad Prebys Foundation for scientific research and education

    A portion of the grant will advance a novel cancer immunotherapy technology at Calibr, the drug discovery and development division of Scripps Research.

  • New genetic links found to rare eye disease, opening the door to better diagnostics and potential treatments
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    New genetic links found to rare eye disease, opening the door to better diagnostics and potential treatments

    The gene mutations explain why patients with MacTel are unable to produce enough of an amino acid needed for eye health.

  • Experimental COVID-19 vaccine takes novel approach to boosting immune response
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    Experimental COVID-19 vaccine takes novel approach to boosting immune response

    The protein-based vaccine delivers particles that mimic the shape of a whole virus; early tests in mice suggest it also may work against variants of SARS-CoV-2.

  • When molecules collide: new method for analyzing sugar-protein interactions could enable better biologic drugs
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    When molecules collide: new method for analyzing sugar-protein interactions could enable better biologic drugs

    The method, aimed at predicting how sugars stabilize proteins, will have broad applications in biology and medicine.

  • Targeting a gene that controls tissue growth, scientists reveal regenerative path for treating diabetic foot ulcers
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    Targeting a gene that controls tissue growth, scientists reveal regenerative path for treating diabetic foot ulcers

    The approach also holds potential for repairing internal organs such as the heart, intestine and liver, which can become damaged by age and disease.

  • Scripps Research adds diverse talent to Board of Directors
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    Scripps Research adds diverse talent to Board of Directors

    The renowned biochemist JoAnne Stubbe and inventor, businessman and philanthropist Herbert Wertheim are elected to the institute's board.

  • Discovery points to possible new treatment strategy for Parkinson’s disease and Lewy body dementia
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    Discovery points to possible new treatment strategy for Parkinson’s disease and Lewy body dementia

    Scientists find evidence that clusters of proteins associated with Parkinson’s and other diseases can induce a toxic process involving glutamate, a neurotransmitter.

  • A new clue to the cause of ALS and frontotemporal dementia
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    A new clue to the cause of ALS and frontotemporal dementia

    Scientists find evidence that reactive nitrogen molecules, abundant in old age, can trigger the disease process for two highly fatal conditions.

  • Huntington’s disease may be driven by slowed protein-building machinery in cells
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    Huntington’s disease may be driven by slowed protein-building machinery in cells

    The results of a new study suggest a possible route for developing therapeutics, and may have implications for multiple neurodegenerative diseases in which ribosome stalling appears to play a role.

    Srinivasa Subramaniam
  • Scripps Research scientist Evert Njomen awarded prestigious Howard Hughes Medical Institute fellowship
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    Scripps Research scientist Evert Njomen awarded prestigious Howard Hughes Medical Institute fellowship

    The Hanna H. Gray Fellowship supports early career life scientists and promotes diversity within the biomedical research community.

  • Thomas Scott Edgington – Polymath, Colleague, Mentor, Friend
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    Thomas Scott Edgington – Polymath, Colleague, Mentor, Friend

    Thomas Edgington, an outstanding scientist and a world leader in the field of vascular biology, passed away Jan. 22, 2021. He enjoyed a 55 year career at Scripps Research.

    Thomas Edgington
  • Experts call for streamlined lab tests of SARS-CoV-2 variants to spot worrisome features
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    Experts call for streamlined lab tests of SARS-CoV-2 variants to spot worrisome features

    Rapid genetic sequencing of COVID-19 virus samples isn’t enough; standardized lab tests are needed to understand potential mutations that may boost infectiousness or enable immune evasion.

  • Bringing ‘deep learning’ to the clinic: scientists overcome key barrier to widespread adoption
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    Bringing ‘deep learning’ to the clinic: scientists overcome key barrier to widespread adoption

    By providing a new level of clarity into how deep learning systems reach their medical diagnoses, scientists hope this AI approach will fuel a new era of preventative medicine.

  • Through ‘All of Us’ program, Scripps Research launches wearable technology study to accelerate precision medicine
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    Through ‘All of Us’ program, Scripps Research launches wearable technology study to accelerate precision medicine

    Scientists will distribute 10,000 Fitbit devices in an effort to understand study participant engagement.

  • Important research antibodies get their close-up
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    Important research antibodies get their close-up

    Structural biologists have created the first-ever atomic-scale maps of antibodies bound to elusive molecules implicated in a range of diseases.

  • In Memoriam: Ralph A. Reisfeld, PhD (1926-2020)
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    In Memoriam: Ralph A. Reisfeld, PhD (1926-2020)

    Ralph Reisfeld, PhD, a longtime senior scientist at Scripps Research and pioneer in the fields of immunology and cancer, passed away at his La Jolla home on December 6, 2020. He was 94.

    Ralph Reisfeld
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