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Scientists find evidence that antibody-based treatments in clinical trials for neurodegenerative diseases may trigger an inflammatory response in human brain immune cells, eroding their positive effects.

A portion of the grant will advance a novel cancer immunotherapy technology at Calibr, the drug discovery and development division of Scripps Research.

The gene mutations explain why patients with MacTel are unable to produce enough of an amino acid needed for eye health.

The protein-based vaccine delivers particles that mimic the shape of a whole virus; early tests in mice suggest it also may work against variants of SARS-CoV-2.

The method, aimed at predicting how sugars stabilize proteins, will have broad applications in biology and medicine.

The approach also holds potential for repairing internal organs such as the heart, intestine and liver, which can become damaged by age and disease.

The renowned biochemist JoAnne Stubbe and inventor, businessman and philanthropist Herbert Wertheim are elected to the institute's board.

Scientists find evidence that clusters of proteins associated with Parkinson’s and other diseases can induce a toxic process involving glutamate, a neurotransmitter.

Scientists find evidence that reactive nitrogen molecules, abundant in old age, can trigger the disease process for two highly fatal conditions.

The results of a new study suggest a possible route for developing therapeutics, and may have implications for multiple neurodegenerative diseases in which ribosome stalling appears to play a role.

The Hanna H. Gray Fellowship supports early career life scientists and promotes diversity within the biomedical research community.

Thomas Edgington, an outstanding scientist and a world leader in the field of vascular biology, passed away Jan. 22, 2021. He enjoyed a 55 year career at Scripps Research.

Rapid genetic sequencing of COVID-19 virus samples isn’t enough; standardized lab tests are needed to understand potential mutations that may boost infectiousness or enable immune evasion.

By providing a new level of clarity into how deep learning systems reach their medical diagnoses, scientists hope this AI approach will fuel a new era of preventative medicine.

Scientists will distribute 10,000 Fitbit devices in an effort to understand study participant engagement.

Structural biologists have created the first-ever atomic-scale maps of antibodies bound to elusive molecules implicated in a range of diseases.

Ralph Reisfeld, PhD, a longtime senior scientist at Scripps Research and pioneer in the fields of immunology and cancer, passed away at his La Jolla home on December 6, 2020. He was 94.

To drive global research efforts, the Center for Viral Systems Biology at Scripps Research is tracking the prevalence of new variants of SARS-CoV-2 and making this information publicly available.

A Scripps Research chemist who employs enzymes as tools to assemble useful natural compounds has been awarded a prestigious 2021 Sloan Research Fellowship for his work.

A sensor protein plays an unexpected and important role in regulating iron levels in the body, according to a new study.

Warning that the next fast-spreading virus may not be as accommodating as the coronavirus driving COVID-19, they call for a new approach to pandemic preparedness.  

The study will leverage genomics and digital technologies to better understand factors that contribute to obesity and type 2 diabetes. 

A phase 1 trial testing a vaccine to prevent HIV has produced promising results, stimulating production of rare immune cells that begin the process of generating antibodies against the fast-mutating virus.

In early tests, the vaccine was able to diminish fatal respiratory effects of fentanyl and carfentanil.