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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • Scripps Research Fellows Program launches new recruiting season, seeking original thinkers
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    Scripps Research Fellows Program launches new recruiting season, seeking original thinkers

    The Scripps Research Fellows Program fosters the next generation of scientific thought-leaders. The application period is now open.

  • Infectious disease sleuth Sumit Chanda, PhD, joins Scripps Research and its Calibr drug discovery division
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    Infectious disease sleuth Sumit Chanda, PhD, joins Scripps Research and its Calibr drug discovery division

    Chanda’s collaborations with the team at Calibr have helped reveal existing drugs that may help boost the effectiveness of current treatments for COVID infection.

  • Scripps Research Professor Chi-Huey Wong receives Robert A. Welch Award in Chemistry
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    Scripps Research Professor Chi-Huey Wong receives Robert A. Welch Award in Chemistry

    Wong has been recognized for revolutionary advances in chemistry and biology.

  • Scripps Research biochemist Jeffery Kelly wins Breakthrough Prize in Life Sciences
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    Scripps Research biochemist Jeffery Kelly wins Breakthrough Prize in Life Sciences

    Scientist focused on the origami of proteins recognized for inventing treatment for heart and neurological diseases, with relevance for Alzheimer’s.

  • Dual-action breast cancer compounds overcome common drug-resistance issues
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    Dual-action breast cancer compounds overcome common drug-resistance issues

    Structure-based drug design strategy reveals a new way to target hormone-sensitive breast cancer.

  • Molecular multi-tools turn existing drug into RNA-targeting compound
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    Molecular multi-tools turn existing drug into RNA-targeting compound

    An existing medication is transformed into an RNA-degrader against cancer and Alport syndrome, thanks to use of a molecular multi-tool from Disney lab.

  • Species of gut bacteria boosts response to cancer immunotherapy—and now we know why
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    Species of gut bacteria boosts response to cancer immunotherapy—and now we know why

    Using the bacteria to ‘remodel’ a patient’s gut microbiota may improve efficacy of checkpoint inhibitors.

  • Chemist Hans Renata named a ‘Talented 12’ top chemist by news magazine C&EN
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    Chemist Hans Renata named a ‘Talented 12’ top chemist by news magazine C&EN

    Florida chemist among “Talented 12” top chemists celebrated by industry magazine.

  • A new approach to curing HIV
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    A new approach to curing HIV

    Scripps Research Florida is helping lead a 12-institution collaborative pursuing a functional cure for HIV. 

  • Polymers “click” together using green chemistry
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    Polymers “click” together using green chemistry

    With applications in drug discovery and materials science, a new library of polymers can be generated in in an environmentally safe way.

  • A new approach to cancer immunotherapy
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    A new approach to cancer immunotherapy

    A team headed by scientists at Scripps Research has devised an immune cell-boosting technique that may enable potent new cancer treatments.

  • Potential drug against COVID-19 found among tapeworm medications
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    Potential drug against COVID-19 found among tapeworm medications

    A new molecule hinders COVID-19 viral replication and related inflammation in rodent studies.

    Chemistry COVID-19
  • Calibr partners with Wellcome Trust to create consortium for neglected tropical diseases
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    Calibr partners with Wellcome Trust to create consortium for neglected tropical diseases

    Collaboration aims to generate new drug candidates for neglected tropical diseases across the globe.

  • Mardi Gras 2020: A Fateful Super-Spreader Event
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    Mardi Gras 2020: A Fateful Super-Spreader Event

    New Orleans’ Mardi Gras festival of February 2020 appears to have driven one of the worst early outbreaks of COVID-19 in the United States, according to a study led by scientists at Scripps Research.

  • Off-target antibodies undermine HIV vaccine efforts
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    Off-target antibodies undermine HIV vaccine efforts

    New understanding of how off-target antibodies hinder HIV vaccines’ success drives design improvements.

  • UF and Scripps Research announce talks to integrate
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    UF and Scripps Research announce talks to integrate

    UF and Scripps Research announced they are in talks to integrate the Florida-based branch of Scripps Research with the research arm of UF’s academic health center.

  • Michael Constantinides receives 2021 Baxter Foundation Young Investigator Award
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    Michael Constantinides receives 2021 Baxter Foundation Young Investigator Award

    The award will support the lab’s investigation of early-life immunity to prevent neonatal infections.

  • Neurons’ couriers deliver cargo to set up long-term memories
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    Neurons’ couriers deliver cargo to set up long-term memories

    Neural plasticity depends on robot-like carrier molecules to deliver their goods from cell body to synapse, a new study finds.

  • Changes in metabolism may produce neurofibromatosis traits, study finds
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    Changes in metabolism may produce neurofibromatosis traits, study finds

    A gene linked to neurofibromatosis causes widespread metabolic disruption in fruit fly models of the neurological disease.

  • K. Barry Sharpless and team named winners of 2021 Royal Society of Chemistry prize for 3-D ‘click chemistry’
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    K. Barry Sharpless and team named winners of 2021 Royal Society of Chemistry prize for 3-D ‘click chemistry’

    The Scripps Research scientists are part of a large collaborative team to win the 2021 Robert Robinson Award in Synthetic Organic Chemistry. 

  • Digital health researchers explore COVID-19’s prolonged effects
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    Digital health researchers explore COVID-19’s prolonged effects

    As part of Scripps Research’s landmark DETECT study, scientists are examining physiological and behavioral changes that often last months after a COVID-19 infection. 

  • Scientists reveal how internal biological clock may suppress tumor growth
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    Scientists reveal how internal biological clock may suppress tumor growth

    New discovery helps explain how disruption to daily biological rhythms, such as long-term rotational shift work, could lead to increased risk of cancer.

  • Scripps Research appoints global health advocate Lillian Lou to Board of Directors
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    Scripps Research appoints global health advocate Lillian Lou to Board of Directors

    Lou brings experience as a biopharma industry leader and a champion for accessible healthcare as she carries on the legacy of life partner John C. Martin.

  • Scientists with diverse expertise to join Scripps Research faculty
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    Scientists with diverse expertise to join Scripps Research faculty

    Protein engineering and autism genetics experts join the faculty, bringing diverse skills and tools.

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