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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • ‘Scavenger’ cells in the nervous system linked to rare genetic disease
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    ‘Scavenger’ cells in the nervous system linked to rare genetic disease

    Calibr, the drug development arm of Scripps Research, and other collaborators find microglia play a critical role in SMA disease progression.

  • Scientists design and validate promising HIV vaccine strategy
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    Scientists design and validate promising HIV vaccine strategy

    Two studies from Scripps Research and collaborators combine bioinformatics and other techniques to develop new vaccine candidates against HIV.

  • New drug has potential to turn COVID-19 virus against itself
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    New drug has potential to turn COVID-19 virus against itself

    Scripps Research team showed that a variation of an already FDA-approved therapeutic for neurological disease can block COVID-19 infection in animals.

  • The surprising link between circadian disruption and cancer may have to do with temperature
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    The surprising link between circadian disruption and cancer may have to do with temperature

    Scripps Research scientists pinpoint an unusual culprit in cancer: a family of genes that respond to temperature changes in the body.

  • Lassa virus endemic area may expand dramatically in coming decades
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    Lassa virus endemic area may expand dramatically in coming decades

    New analysis finds that climate change and other factors could soon make deadly Lassa fever a much bigger public health problem in Africa

  • Detecting the earliest population changes of COVID-19 activity with wearable devices
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    Detecting the earliest population changes of COVID-19 activity with wearable devices

    New data from Scripps Research shows how sensors can provide real-time COVID-19 tracking and forecasting

    COVID-19
  • Calibr reports promising results from first-in-human clinical trial of switchable CAR-T (CLBR001 + SWI019), a next-generation universal CAR-T platform designed to enhance the versatility and safety of cell therapies
    News

    Calibr reports promising results from first-in-human clinical trial of switchable CAR-T (CLBR001 + SWI019), a next-generation universal CAR-T platform designed to enhance the versatility and safety of cell therapies

    Calibr has announced encouraging preliminary data from the first nine subjects in a first-in-human Phase 1 clinical trial studying the first switchable CAR-T cell product (CLBR001 + SWI019) for patients with B cell malignancies.

    Calibr-Skaggs Travis Young
  • Scripps Research discovery suggests new strategy against harmful inflammation
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    Scripps Research discovery suggests new strategy against harmful inflammation

    Scientists identify WASH protein complex as a gatekeeper of neutrophil-driven inflammation

  • Raphael (Donghyun) Park joins Scripps Research Fellows Program to develop novel ways of addressing tuberculosis
    News

    Raphael (Donghyun) Park joins Scripps Research Fellows Program to develop novel ways of addressing tuberculosis

    Park’s expertise in high-resolution imaging will enable a detailed look at bacterial pathogenesis.

  • Scripps Research scientists eavesdrop on communication between fat and brain
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    Scripps Research scientists eavesdrop on communication between fat and brain

    Newly discovered sensory neurons send messages from fat tissue to the brain and could eventually be co-opted to treat obesity or metabolic disease.

  • Scripps Research awarded NIH BRAIN Initiative grant to map undiscovered parts of the central nervous system
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    Scripps Research awarded NIH BRAIN Initiative grant to map undiscovered parts of the central nervous system

    The $2.3 million award will support development of the first molecular toolkit that uncovers the brain’s “translatome” to better understand neural cognition, behavior and disease.

  • New research model illuminates how organs communicate with each other
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    New research model illuminates how organs communicate with each other

    Scientists uncover the proteins involved in key communication networks, which could help us better understand conditions like cancer and obesity.

  • Scripps Research scientists identify how SARS-CoV-2 spreads in the Middle East
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    Scripps Research scientists identify how SARS-CoV-2 spreads in the Middle East

    Findings highlight biases in viral sampling and urgent need for better global health infrastructure.

  • Scripps Research scientists discover antibodies that induce broad immunity against SARS viruses, including emerging variants
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    Scripps Research scientists discover antibodies that induce broad immunity against SARS viruses, including emerging variants

    Finding opens the door for new vaccine approaches and strategies.

  • Scripps Research, UCLA chemists achieve “molecular editing” feat
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    Scripps Research, UCLA chemists achieve “molecular editing” feat

    New techniques enable unprecedented versatility in the design of drug molecules.

  • Scripps Research scientists discover new “origins of life” chemical reactions
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    Scripps Research scientists discover new “origins of life” chemical reactions

    The reaction generates amino acids and orotic acid, the building blocks of proteins and DNA.

  • Pair of studies illuminates COVID-19 pandemic origins
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    Pair of studies illuminates COVID-19 pandemic origins

    Analyses based on locations and viral sequencing of early cases suggest pandemic started in Wuhan’s Huanan market, with two separate jumps from animals to humans.

  • Chi-Huey Wong awarded Tetrahedron Prize for Creativity in Organic Synthesis
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    Chi-Huey Wong awarded Tetrahedron Prize for Creativity in Organic Synthesis

    Wong’s discoveries and technologies have fundamentally shaped our understanding of complex carbohydrates and glycoproteins, as well as uncovered new therapeutic strategies to treat major diseases.

  • Cellular protein identified as possible drug target to combat Lassa hemorrhagic fever
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    Cellular protein identified as possible drug target to combat Lassa hemorrhagic fever

    Experimental approach could uncover new treatment options for the virus, which is highly prevalent in Western Africa.

    e, Juan Carlos de la Torre
  • Alejandra Mendoza joins Scripps Research faculty to unravel the neuro-immune connection
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    Alejandra Mendoza joins Scripps Research faculty to unravel the neuro-immune connection

    Mendoza’s research focuses on the interwoven circuits that drive inflammation, pain and immunological diseases.

  • Immune system uses two-step verification to defend against HIV
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    Immune system uses two-step verification to defend against HIV

    Scripps Research discovery could offer new methods for treating HIV, while uncovering the innate immune system’s role in other diseases.

  • Scientists develop tools for early detection of SARS-CoV-2 variants in wastewater
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    Scientists develop tools for early detection of SARS-CoV-2 variants in wastewater

    New tools developed at Scripps Research and UC San Diego are helping public health officials around the world get vital information about pathogen variants from wastewater.

  • Xin Jin named one of 35 Innovators Under 35 by MIT Technology Review
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    Xin Jin named one of 35 Innovators Under 35 by MIT Technology Review

    Recognizing outstanding innovators younger than 35, the annual list examines not just where technology is now, but where it’s going and who’s taking it there.

  • Scripps Research scientists identify sensor underlying mechanical itch
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    Scripps Research scientists identify sensor underlying mechanical itch

    Finding could lead to better drug treatments for chronic itch conditions, like eczema.

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Life-changing Medicine.