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Where hypotheses become headlines: Featured coverage of the breakthroughs—and the people—driving our research forward

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The Scripps Research scientists leading the Huang Foundation-supported projects. From left: Terrence Messmer, Sarah Burbach, Matthew Holcomb, Bryan Briney, Stefano Forli, Benjamin Cravatt, Christopher Parker, Andrew Ward and Charles Bowman.
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Scripps Research garners major support for AI innovations in biomedicine with compute grant from Jen-Hsun and Lori Huang Foundation

Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

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  • Antibody blunts heroin’s lethality, paving the way for a promising new therapy
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    Antibody blunts heroin’s lethality, paving the way for a promising new therapy

    Scripps Research findings unexpectedly show that heroin, not its metabolites, is the best therapeutic target.

  • Scripps Research awarded NIH grant to enhance biosafety level 3 facility to address viruses of pandemic concern
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    Scripps Research awarded NIH grant to enhance biosafety level 3 facility to address viruses of pandemic concern

    The $3.8 million award will expand the institute’s research programs aimed at identifying therapeutics for various RNA viruses.

  • Scripps Research scientists map key protein structure of Hepatitis C virus
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    Scripps Research scientists map key protein structure of Hepatitis C virus

    Discovery points the way toward an effective HCV vaccine.

  • New tool reveals what happens in the brain when we learn
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    New tool reveals what happens in the brain when we learn

    A Scripps Research team measured how levels of various proteins in brain cells change in response to brain activity.

  • Drug discovery method identifies naturally occurring metabolite that converts ‘bad’ fat to ‘good’ fat
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    Drug discovery method identifies naturally occurring metabolite that converts ‘bad’ fat to ‘good’ fat

    Scripps Research and Calibr scientists collaborate to uncover potential therapeutic avenues for metabolic diseases.

  • Scripps Research receives $2.5M CDC contract for SARS-CoV-2 surveillance program
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    Scripps Research receives $2.5M CDC contract for SARS-CoV-2 surveillance program

    Work will include fast analyses of virus transmission in the San Diego area and across the U.S.- Mexico border.

  • Scripps Research professor K. Barry Sharpless receives 2022 Nobel Prize in Chemistry
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    Scripps Research professor K. Barry Sharpless receives 2022 Nobel Prize in Chemistry

    Sharpless awarded his second Nobel Prize in Chemistry–one of only two chemists to ever receive such an honor.

  • ‘Scavenger’ cells in the nervous system linked to rare genetic disease
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    ‘Scavenger’ cells in the nervous system linked to rare genetic disease

    Calibr, the drug development arm of Scripps Research, and other collaborators find microglia play a critical role in SMA disease progression.

  • Scientists design and validate promising HIV vaccine strategy
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    Scientists design and validate promising HIV vaccine strategy

    Two studies from Scripps Research and collaborators combine bioinformatics and other techniques to develop new vaccine candidates against HIV.

  • New drug has potential to turn COVID-19 virus against itself
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    New drug has potential to turn COVID-19 virus against itself

    Scripps Research team showed that a variation of an already FDA-approved therapeutic for neurological disease can block COVID-19 infection in animals.

  • The surprising link between circadian disruption and cancer may have to do with temperature
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    The surprising link between circadian disruption and cancer may have to do with temperature

    Scripps Research scientists pinpoint an unusual culprit in cancer: a family of genes that respond to temperature changes in the body.

  • Lassa virus endemic area may expand dramatically in coming decades
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    Lassa virus endemic area may expand dramatically in coming decades

    New analysis finds that climate change and other factors could soon make deadly Lassa fever a much bigger public health problem in Africa

  • Detecting the earliest population changes of COVID-19 activity with wearable devices
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    Detecting the earliest population changes of COVID-19 activity with wearable devices

    New data from Scripps Research shows how sensors can provide real-time COVID-19 tracking and forecasting

    COVID-19
  • Calibr reports promising results from first-in-human clinical trial of switchable CAR-T (CLBR001 + SWI019), a next-generation universal CAR-T platform designed to enhance the versatility and safety of cell therapies
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    Calibr reports promising results from first-in-human clinical trial of switchable CAR-T (CLBR001 + SWI019), a next-generation universal CAR-T platform designed to enhance the versatility and safety of cell therapies

    Calibr has announced encouraging preliminary data from the first nine subjects in a first-in-human Phase 1 clinical trial studying the first switchable CAR-T cell product (CLBR001 + SWI019) for patients with B cell malignancies.

    Calibr-Skaggs Travis Young
  • Scripps Research discovery suggests new strategy against harmful inflammation
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    Scripps Research discovery suggests new strategy against harmful inflammation

    Scientists identify WASH protein complex as a gatekeeper of neutrophil-driven inflammation

  • Raphael (Donghyun) Park joins Scripps Research Fellows Program to develop novel ways of addressing tuberculosis
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    Raphael (Donghyun) Park joins Scripps Research Fellows Program to develop novel ways of addressing tuberculosis

    Park’s expertise in high-resolution imaging will enable a detailed look at bacterial pathogenesis.

  • Scripps Research scientists eavesdrop on communication between fat and brain
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    Scripps Research scientists eavesdrop on communication between fat and brain

    Newly discovered sensory neurons send messages from fat tissue to the brain and could eventually be co-opted to treat obesity or metabolic disease.

  • Scripps Research awarded NIH BRAIN Initiative grant to map undiscovered parts of the central nervous system
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    Scripps Research awarded NIH BRAIN Initiative grant to map undiscovered parts of the central nervous system

    The $2.3 million award will support development of the first molecular toolkit that uncovers the brain’s “translatome” to better understand neural cognition, behavior and disease.

  • New research model illuminates how organs communicate with each other
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    New research model illuminates how organs communicate with each other

    Scientists uncover the proteins involved in key communication networks, which could help us better understand conditions like cancer and obesity.

  • Scripps Research scientists identify how SARS-CoV-2 spreads in the Middle East
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    Scripps Research scientists identify how SARS-CoV-2 spreads in the Middle East

    Findings highlight biases in viral sampling and urgent need for better global health infrastructure.

  • Scripps Research scientists discover antibodies that induce broad immunity against SARS viruses, including emerging variants
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    Scripps Research scientists discover antibodies that induce broad immunity against SARS viruses, including emerging variants

    Finding opens the door for new vaccine approaches and strategies.

  • Scripps Research, UCLA chemists achieve “molecular editing” feat
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    Scripps Research, UCLA chemists achieve “molecular editing” feat

    New techniques enable unprecedented versatility in the design of drug molecules.

  • Scripps Research scientists discover new “origins of life” chemical reactions
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    Scripps Research scientists discover new “origins of life” chemical reactions

    The reaction generates amino acids and orotic acid, the building blocks of proteins and DNA.

  • Pair of studies illuminates COVID-19 pandemic origins
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    Pair of studies illuminates COVID-19 pandemic origins

    Analyses based on locations and viral sequencing of early cases suggest pandemic started in Wuhan’s Huanan market, with two separate jumps from animals to humans.

Groundbreaking Science.
Life-changing Medicine.