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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • Scripps Research receives $1.5M to surveil infectious disease threats in wastewater
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    Scripps Research receives $1.5M to surveil infectious disease threats in wastewater

    Bill & Melinda Gates Foundation award to support the development of multi-pathogen wastewater surveillance tools and protocols.

  • How cold temperatures trigger the brain to boost appetite
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    How cold temperatures trigger the brain to boost appetite

    Scripps Research scientists’ discovery could lead to new weight loss and metabolic health treatments.

  • Scripps Research scientists reveal how sensory protein changes shape with nanometer resolution
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    Scripps Research scientists reveal how sensory protein changes shape with nanometer resolution

    The sensory receptor PIEZO1 changes shape in response to mechanical stimuli. The super high-resolution microscopy technology used in this discovery is a breakthrough in enabling protein structures to be studied within the cellular environment.

  • Human antibody that targets carfentanil, fentanyl and related opioids reverses overdose effects in preclinical study
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    Human antibody that targets carfentanil, fentanyl and related opioids reverses overdose effects in preclinical study

    Scripps Research-developed antibody therapy appears to have advantages over existing opioid-overdose treatments.

  • “Spider-like” mitochondrial structure initiates cell-wide stress response
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    “Spider-like” mitochondrial structure initiates cell-wide stress response

    Scripps Research scientists discovered the unique molecular structure, which could have implications in age-related diseases like neurodegeneration.

  • How sensory neurons impact the gut
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    How sensory neurons impact the gut

    Scripps Research scientists show that the receptor PIEZO2 in sensory neurons controls gut motility and transit time, which are important for digestion and nutrient absorption.

  • AbbVie and Calibr Expand Strategic Collaboration to Advance Several Preclinical and Early-stage Clinical Assets
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    AbbVie and Calibr Expand Strategic Collaboration to Advance Several Preclinical and Early-stage Clinical Assets

    The expanded strategic collaboration will advance several innovative assets across AbbVie’s core therapeutic growth areas including immunology, oncology, neuroscience.

  • Calibr launches first-in-human phase 1 clinical trial in healthy volunteers evaluating PDM608, an investigative drug developed for the treatment of neurodegenerative diseases
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    Calibr launches first-in-human phase 1 clinical trial in healthy volunteers evaluating PDM608, an investigative drug developed for the treatment of neurodegenerative diseases

    Calibr scientists engineered a cytokine protein that has shown evidence of providing neuroprotective effects to Parkinson’s disease patients.

  • Blocking glutamate release reduces oxycodone intake and seeking behavior
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    Blocking glutamate release reduces oxycodone intake and seeking behavior

    In a preclinical study, Scripps Research scientists show that the drug ADX106772 (Addex Therapeutics) reduced oxycodone intake and relapse, without disrupting the brain’s natural reward system.

  • Scripps Research scientists develop AI-based tracking and early-warning system for viral pandemics
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    Scripps Research scientists develop AI-based tracking and early-warning system for viral pandemics

    Machine-learning system effectively predicts emergence of prominent variants.

  • Major depressive disorder therapy to enter Phase 3 pivotal clinical trials
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    Major depressive disorder therapy to enter Phase 3 pivotal clinical trials

    Navacaprant, a monotherapy discovered at Scripps Research, showed clinically meaningful improvements for people with moderate-to-severe MDD in a recently completed Phase 2 study.

  • Scripps Research awarded $9.8 million by NIH to address deadly bacterial infections
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    Scripps Research awarded $9.8 million by NIH to address deadly bacterial infections

    The program grant will support the development of high-affinity antibodies that can target skin and lung infections, as well as sexually transmitted diseases.

  • Scripps Research mourns passing of immunology professor and virology pioneer Michael Oldstone
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    Scripps Research mourns passing of immunology professor and virology pioneer Michael Oldstone

    A leader in viral pathogenesis, Oldstone helped shape our modern understanding of viruses and how the immune system responds to these microbial threats.

  • Monitoring T cells may allow prevention of type 1 diabetes
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    Monitoring T cells may allow prevention of type 1 diabetes

    Scripps Research study shows that analyzing T cells in blood samples could be used to select at-risk patients for type 1 diabetes preventive therapy.

  • Study optimizes patient-specific stem cell-based therapy for Parkinson’s disease
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    Study optimizes patient-specific stem cell-based therapy for Parkinson’s disease

    The discovery by scientists from Scripps Research and Cardiff University paves the way for clinical trials that use patients’ own cells to treat Parkinson’s disease.

    Translational Medicine Parkinson's Disease
  • Scripps Research mourns passing of leading organic chemist Albert Eschenmoser
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    Scripps Research mourns passing of leading organic chemist Albert Eschenmoser

    Eschenmoser pioneered key reactions in synthetic chemistry and shaped the understanding of how life may have first originated on Earth.

  • Eric Topol and Julia Moore Vogel
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    Scripps Research receives momentous award from NIH to lead key programs in national All of Us Research Program

    The award renews support for Scripps Research Translational Institute and partner organizations involved in expanding one of the largest and most inclusive health data resources of its kind.

  • Eric Topol, MD
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    Scripps Research awarded $46.8 million by NIH to promote human health through innovative translational science and training

    The Translational Institute is harnessing genomic and digital technologies with machine learning to revolutionize health research.

  • Scripps Research’s Danielle Grotjahn named 2023 Pew Scholar in the Biomedical Sciences
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    Scripps Research’s Danielle Grotjahn named 2023 Pew Scholar in the Biomedical Sciences

    The award will support Grotjahn’s study of how cells assemble the molecular machinery that governs programmed cell death.  

  • Excessive alcohol consumption may accelerate Alzheimer’s disease progression
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    Excessive alcohol consumption may accelerate Alzheimer’s disease progression

    Scripps Research and University of Bologna scientists showed how excessive alcohol consumption in animals can hasten cognitive decline in those genetically predisposed to Alzheimer’s disease.

  • Crossing the ring: new method enables C-H activation across saturated carbocycles
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    Crossing the ring: new method enables C-H activation across saturated carbocycles

    Scripps Research chemists add another powerful tool to their “molecular editing” toolkit for crafting pharmaceuticals and other valuable compounds.

  • Deadly virus structures point toward new avenues for vaccine design
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    Deadly virus structures point toward new avenues for vaccine design

    By comparing the structures of protein complexes from different lineages of the dangerous Lassa virus, a Scripps Research team identified new antibodies and vaccine targets.

  • Scripps Research develops behind-the-scenes tool for better biomedical data discovery
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    Scripps Research develops behind-the-scenes tool for better biomedical data discovery

    The new resource makes datasets more discoverable for life science community.

  • Scripps Research’s Skaggs Graduate School awards doctoral degrees to 31st graduating class
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    Scripps Research’s Skaggs Graduate School awards doctoral degrees to 31st graduating class

    Commencement ceremony will be livestreamed via Zoom and on institute’s Facebook page.

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