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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • News

    Scripps Florida Scientists Confirm Quality Control Mechanism to Protect Protein Production

    "We now understand how this complicated assembly process works."

  • News

    Scripps Florida Scientists Identify Compounds That Significantly Increase Healthy Aging

    Scientists from the Florida campus of The Scripps Research Institute have identified a class of compounds that significantly delays the onset of several age-related symptoms

    New Therapies Paul Robbins
  • News

    New Exploratory Grant Will Help Scripps Florida Scientists Advance Treatment Development

    "Clearly, there is an urgent need to develop better options for these patients."

  • Scripps Research Adds New Faculty To World-Class Institute
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    Scripps Research Adds New Faculty To World-Class Institute

    One new assistant and one new associate professor to join the institute’s La Jolla and Jupiter campuses, respectively.

  • News

    Researchers Develop Assay to Help Identify New Pain Medication Candidates

    Researchers have developed a test that will help scientists identify new drug candidates for treating pain that have fewer side effects, like addiction.

    Neuroscience Scott Hansen
  • News

    New Research Reveals Pathway for Anti-Aging Therapies

    Two new studies led by scientists at Scripps Research could guide future therapies to improve health and lifespan.

  • News

    Scientists Awarded $11 Million Grant Renewal by NIAID for Long-Running Study of Immunity, Inflammation

    "It is one of the most productive large-scale science grants that NIAID funds."

  • News

    Researchers Find A Way to Combat Pharmacoterrorism

    New method provides researchers with a new way to understand such drug compounds, especially where individual components or metabolites interact to produce the complete effects of psychoactive species.

  • News

    Chemist Keary Engle Receives NIH’s Outstanding Investigator Award

    The five-year award provides general, long-term support for research programs that are deemed especially promising.

  • Scripps Research Scientist Wins Prestigious Young Investigator Award
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    Scripps Research Scientist Wins Prestigious Young Investigator Award

    Staff Scientist Kathryn Hastie of The Scripps Research Institute (TSRI) has won the 2017 William E. and Diane M. Spicer Young Investigator Award.

  • Scripps Research Ranks No. 1 in Innovation Influence
    News

    Scripps Research Ranks No. 1 in Innovation Influence

    Annual Nature Index supplement ranks research institutes on influence over scientific patents.

  • Chemists Develop Inexpensive, Versatile Technique for Making RNA
    News

    Chemists Develop Inexpensive, Versatile Technique for Making RNA

    Scientists at The Scripps Research Institute have developed a highly efficient new method for making ribonucleic acid (RNA) molecules in the laboratory.

  • One Cytokine To Control Multiple Cytokines
    News

    One Cytokine To Control Multiple Cytokines

    Scripps Research study of interferon gamma reveals new principle of cell signaling.

  • News

    Scripps Florida Scientists Identify Protein Deficiency Involved in Childhood Anemia and Cancers

    These new findings provide the first molecular understanding of the pathology of the disease known as Diamond-Blackfan anemia.

  • News

    Protein Profiling Method Reveals Many Potential New Drug Targets

    Scientists at Scripps Research have invented a versatile method for identifying proteins that can feasibly be targeted with drugs to treat disease.

  • Competition for Survival Signals Maintains Immune Balance
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    Competition for Survival Signals Maintains Immune Balance

    Future studies will attempt to explain the biological significance of these two distinct cell types competing for a shared source of survival stimuli.

  • News

    NIH-supported scientists elicit broadly neutralizing antibodies to HIV in calves

    In their study, the researchers injected HIV immunogens into the flanks of four calves and waited for their immune systems to respond.

  • Scientists Capture First High Resolution Image of Key HIV Protein Transitional State
    News

    Scientists Capture First High Resolution Image of Key HIV Protein Transitional State

    Atomic-scale snapshot reveals new regions on HIV’s envelope trimer protein that could be targets for small molecule inhibitor development.

  • News

    Scripps Florida Scientists Awarded $2 Million to Develop ‘Industrial Level’ Screening for Treatments of Autism-Related Intellectual Disability

    A team of scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded nearly $2 million from the National Institute of Mental Health of the National Institutes of Health.

  • News

    Exercise Performance in Mice Depends on Circadian Rhythms

    Mice in new Scripps Research study sprinted faster but had less endurance over longer distances.

  • A Perspective on the Biology of Forgetting
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    A Perspective on the Biology of Forgetting

    Scientists have a long way to go to fully understand how our brains forget unused and unimportant memories and make space for new ones.

  • San Diego Team Tests Best Delivery Mode for Potential HIV Vaccine
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    San Diego Team Tests Best Delivery Mode for Potential HIV Vaccine

    Optimized immunizations reliably elicit protective antibodies in preclinical study, marking an important milestone on the way to an effective HIV vaccine.

  • News

    Firefly Gene Illuminates Ability of Optimized CRISPR-Cpf1 to Efficiently Edit Human Genome

    Scripps Research scientists have improved a state-of-the-art gene-editing technology to advance the system’s ability to target, cut and paste genes within human and animal cells.

  • News

    Scripps Florida Scientist and Collaborators Win $7 Million Grant to Develop New ALS Treatments

    "The new grant supports the idea that RNA is a legitimate target to treat disease."

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