News

The American Association for Cancer Research has named Michalina Janiszewska, PhD, a “NextGen Star”.

The American Society for Microbiology has elected Scripps Research Professor Michael Farzan, PhD, to its American Academy of Microbiology.

Huge-scale sequencing study also points to future use of human “antibody repertoires” for disease diagnosis and vaccine design.

Mice lacking BDNF in certain brain regions showed signs of anxiety. They also had an elevated basal metabolic rate.

Defects in the transport of cells’ energy organelles are a suspected cause of diseases including Alzheimer’s, ALS, Huntington’s and Parkinson’s. A new study uncovers how mitochondria move in neurons.

When alcohol reaches our nerve cells, the alcohol connects with intermediary molecules on the neuron’s membrane surface to produce its intoxicating effects, indirectly.

Lasmézas and her team find that enzymes modify tau to create tau-a-synuclein clumps on mitochondria, leading ultimately to the death of neurons.

This video by Boston Globe’s STAT magazine features Calibr’s ReFRAME collection, a drug repurposing project that’s finding ways to treat new diseases with existing drugs.

Individual neurons can have multiple kinesins in motion at the same time, moving like trucks on a highway, a study from the Puthanveettil lab finds.

Friedbert Weiss, PhD, a professor of neuroscience at Scripps Research, has been named a fellow of the American Association for the Advancement of Science (AAAS). Election as an AAAS Fellow is an honor bestowed upon its members by their peers.

Recent discovery improves understanding of a protein’s role in several autoimmune disorders, including Singleton–Merten syndrome (SMS), Aicardi-Goutières syndrome, familial chilblain lupus, proteasome associated autoinflammatory syndromes and many others which involve improper stimulation of interferon.

Researchers demonstrate new microscopy technique for studying complex biological processes at the molecular level. The technique allows scientists to observe critical steps in the production of ribosomes, protein-building cellular machines.

Since the ice bucket challenge went viral in 2014, raising awareness and funding for ALS research, scientists have learned much about a disease that disconnects muscles from nerves, leading to muscle atrophy and eventual death. Their ultimate goal is to create medications capable of stopping ALS in its tracks.

For more than 20 years, scientists at Scripps Research have chipped away at the challenges of designing an HIV vaccine. Now new research, published in Immunity, shows that their experimental vaccine strategy works in non-human primates.

Recent study finds that the brain regulates normal eating and antipsychotic-induced overeating through distinct mechanisms. Scientists found that an FDA-approved medication called minocycline has the potential to counteract this overeating.

A group of diabetes drugs that have fallen out of favor due to side-effects may merit renewed attention after scientists at Scripps Research discovered a way to capitalize on the insulin-sensitizing talent of the drug receptor while limiting its ability to cause weight gain, brittle bones and other impacts. 

A new Scripps Research study finds that receptors for a Parkinson’s-associated gene product have a pocket needed to bind to other molecules, opening the ability to more accurately probe its role in disease, and possibly develop a new class of therapies.

Scripps Research scientists have developed a quick, cheap way to attach entire antibodies to living cells.

Scripps Research scientists have made a major breakthrough in unveiling this medical mystery by precisely cutting the DNA culprit from the genome, which prevents blood vessel cell abnormalities related to these devastating diseases.

Floyd Romesberg, PhD, a professor of chemistry at Scripps Research, proves it is not in his engaging TED talk.

Scientists from Scripps Research deciphered how the proteasome converts energy into mechanical motion that untangles and unfolds proteins for destruction. The findings, published in Science, could help us understand how proteasomes keep diseases such as Parkinson’s and Alzheimer’s at bay.

Michael B.A. Oldstone, MD, and Erica Ollmann Saphire, PhD were recognized by the Global Virus Network (GVN) for their leadership in the field of medical virology.

Neurons communicate with each other by exchanging gifts — sending molecules back and forth across the synapse in tiny packages called synaptic vesicles. A team from Scripps Research has shown that the number of these vesicles, not only the number of synapses, plays an important role in how neurons share information. Moreover, increases in the number of vesicles at specific types of synapses lead to better memory formation.

Scientists at Scripps Research have found that minocycline can increase the lifespan of roundworms by preventing the buildup of proteins during aging, according to a study in the open-access journal eLife reports.