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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • Sydney Brenner, Nobel laureate and genetics pioneer, dies at 92
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    Sydney Brenner, Nobel laureate and genetics pioneer, dies at 92

    Brenner devoted his career to conducting groundbreaking basic research. His many contributions to molecular biology led to his being co-awarded the Nobel Prize in Physiology or Medicine in 2002.

  • New study suggests oxytocin could help treat alcohol addiction
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    New study suggests oxytocin could help treat alcohol addiction

    In a study with the National Institute on Drug Abuse, scientists at Scripps Research discovered that oxytocin blocked enhanced drinking in alcohol-dependent rats, concluding that targeting the oxytocin system may be a successful pharmaceutical approach for treating alcohol-use disorder.

  • Molecules that prevent protein misfolding point to new type of therapy for AL amyloidosis
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    Molecules that prevent protein misfolding point to new type of therapy for AL amyloidosis

    Scientists at Scripps Research have identified a group of small molecules that prevent structural changes to proteins that are at the root of AL amyloidosis, a progressive and often fatal disease.

  • Mouse model develops Parkinson’s just like humans, opening the door to more accurate drug screening
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    Mouse model develops Parkinson’s just like humans, opening the door to more accurate drug screening

    New research will now make it possible to screen drug candidates more reliably and investigate the root cause of Parkinson’s disease.

    Steven Reed
  • Scripps Research receives highest possible charity rating
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    Scripps Research receives highest possible charity rating

    Charity Navigator awards Scripps Research four stars for exceeding industry standards in financial health, accountability and transparency.

  • Chemistry feat suggests the building blocks of DNA and RNA could have appeared together before life began on earth
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    Chemistry feat suggests the building blocks of DNA and RNA could have appeared together before life began on earth

    Scientists find evidence that RNA and DNA could have arisen from the same set of precursor molecules before life evolved four billion years ago.

  • Leading cause of muscular dystrophy in adults responds to new treatment
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    Leading cause of muscular dystrophy in adults responds to new treatment

    Currently there is no treatment for myotonic dystrophy type 1. Now, researchers say they have made a potential drug that targets a disease-causing RNA at the root of the disease.  

  • Scripps Research discoveries pave way to clinical trial of new type of HIV vaccine
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    Scripps Research discoveries pave way to clinical trial of new type of HIV vaccine

    The International AIDS Vaccine Initiative (IAVI) announced the start of a Phase I clinical trial to test a novel HIV vaccine candidate, an advance in vaccine design enabled by Scripps Research discoveries.

    HIV/AIDS Vaccines
  • Discovery of life-extension pathway in worms demonstrates new way to study aging
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    Discovery of life-extension pathway in worms demonstrates new way to study aging

    New method could enable faster study of strategies to combat age-related diseases.

  • Trio of new medicines originate from Scripps Research discoveries
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    Trio of new medicines originate from Scripps Research discoveries

    New drugs for neurodegenerative and genetic disorders making their way to the marketplace.

  • Scientists hunt down the brain circuit responsible for alcohol cravings
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    Scientists hunt down the brain circuit responsible for alcohol cravings

    Scientists at Scripps Research have found that they can reverse the desire to drink in alcohol-dependent rats—with the flip of a switch.

  • Robot hand holding a red apple.
    News

    Eric Topol pens book on artificial intelligence in medicine

    New book Deep Medicine released and garners significant media attention. Click to read more and review ongoing media coverage. 

  • Scientists discover a potential strategy to treat influenza A
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    Scientists discover a potential strategy to treat influenza A

    In a breakthrough with applicability across many flu strains, researchers find a potential small molecule that mimics antibodies to treat disease.

  • News

    Stroke drug treats mouse model of Alzheimer’s disease

    For the last decade researchers have been developing a drug candidate that eases inflammation and protects brain cells from damage. Now, research shows another potential application: treating Alzheimer’s disease. 

    Translational Medicine Alzheimer’s Disease
  • The A.I. Diet
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    The A.I. Diet

    In a New York Times op-ed, Eric Topol, MD, founder and director of Scripps Research Translational Institute, discusses the science of nutrition and the need for diet to be individualized.

  • Promising compound selectively kills brain cancer stem cells
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    Promising compound selectively kills brain cancer stem cells

    Scripps Research assistant professor Luke Lairson, PhD, and colleagues have discovered a compound that potently and selectively kills the stem-like cells that make glioblastoma brain cancers so deadly.

  • UK National Health Service launches Topol Program for Digital Fellowships in Healthcare
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    UK National Health Service launches Topol Program for Digital Fellowships in Healthcare

    Program supports workforce training recommended by Eric Topol, MD, in an independent review of the digital future of the National Health Service.

  • Electric car batteries inspire safer, cheaper way to manufacture compounds used in medicines
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    Electric car batteries inspire safer, cheaper way to manufacture compounds used in medicines

    Inspired by electric car batteries, researchers developed a battery-like system that allows them to make potential advancements for the manufacturing of medicines.

  • Ramanarayanan Krishnamurthy named co-leader of NASA program to study chemical origins of life
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    Ramanarayanan Krishnamurthy named co-leader of NASA program to study chemical origins of life

    Scripps Research professor Ramanarayanan Krishnamurthy, PhD, has been named co-leader of a new NASA initiative to investigate how life emerged from Earth’s early environments.

  • Engineered immune cells produce antibodies to fight HIV
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    Engineered immune cells produce antibodies to fight HIV

    Cells removed from patients’ bloodstreams and genetically altered may allow more effective vaccines for HIV, influenza, hepatitis.

    Immunology & Microbiology HIV/AIDS James Voss
  • Whitehall Foundation honors two pioneering Scripps Research scientists
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    Whitehall Foundation honors two pioneering Scripps Research scientists

    Neuroscientists Giordano Lippi and Li Ye have received grants from the Whitehall Foundation to support their studies into brain function.

  • Breast cancer cells shifted into HER2 positive status with bold new strategy
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    Breast cancer cells shifted into HER2 positive status with bold new strategy

    For breast cancer patients with dwindling options, switching on HER2 sensitivity might be life-changing. Disney’s group described shifting three different cancer cell lines from HER2-negative status to HER2-positive status with the addition of a selective micro-RNA binding molecule.

  • Synapse maintenance depends on network within neurons, study finds
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    Synapse maintenance depends on network within neurons, study finds

    Synapse instability may underlie many neurodegenerative diseases, including Alzheimer’s. A new study from the lab of Brock Grill, PhD, sheds light on synapse maintenance.  

  • Scripps Research Chemist Matthew D. Disney Awarded the Sackler Prize
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    Scripps Research Chemist Matthew D. Disney Awarded the Sackler Prize

    Chemistry Professor Matthew D. Disney, PhD, of Scripps Research in Jupiter, Florida, has been awarded the Raymond and Beverly Sackler International Prize in Chemistry from Tel Aviv University.

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