News

An unexpected finding from Scripps Research has illuminated a promising strategy for treating the inherited neurological disease Charcot-Marie-Tooth, for which there is no approved medicine today.

Neuroscientists at Scripps Research have identified a molecule in brain cells that regulates autophagy, an important cellular waste-recycling system implicated in a range of brain disorders.

Scientists found a way to survey the landscape of proteins that exist in human cells and identify druggable areas that are still flying under the radar of modern medicine.

A new approach that targets young immune cells may also work for creating vaccines against the flu, dengue, malaria and hepatitis C.

In research that holds potential for prenatal health and brain injury, Scripps Research neuroscientists identify cellular workings that stop and restart early brain development. 

Researchers found an antibody that protects against a wide range of potentially lethal influenza viruses, advancing efforts to design of a universal vaccine.

A Scripps Research team has discovered a molecular process in brain cells that may be a major driver of drug addiction, and thus may become a target for future addiction treatments.

Cline is honored as an inspiring scientific role model, having trained more than 40 graduate students and postdoctoral scientists in her lab, over half of whom are women.

Scientists at Scripps Research believe they have found a way to sidestep some of the current difficulties of gene therapy, resulting in a more efficient delivery method that would save money and improve treatment outcomes.

Chemists at Scripps Research have invented an efficient method for making a synthetic version of the plant compound bilobalide, which holds potential commercial value for medicines and “green” insecticides.

The technique compares activity levels of maternal and paternal alleles across the genome and detects when the activity lies far enough outside the normal range to be a plausible cause of disease.

Compounds called cyclophospholipids would have held up against the planet’s harsh conditions, helping the first cells form and proliferate. 

A team including Nobel laureate chemist K. Barry Sharpless, PhD, has discovered an easy, efficient type of chemical reaction that could become widely useful in building potential new drug molecules and other valuable chemical products.

‘RNA – From Biology to Drug Discovery,’ day-long conference, to be held on the Jupiter, Florida campus of Scripps Research, to focus on translational promise of a novel targeting strategy. 

Scripps Research scientists make a key discovery into the underpinnings of a complex disease that damages patients' peripheral nervous system. 

The launch of the Florida campus of Scripps Research has produced an economic impact of $3 billion since the nonprofit biomedical institute opened an East Coast branch 15 years ago. 

Vogt's work led to the discovery of the first oncogene and many other other genetic drivers of cancer. Of the 100-plus Horwitz Prize winners to date, 50 percent have gone on to receive Nobel Prizes. 

A hypothesis known as RNA World is a fascinating explanation for how life began, but it may not hold true. The problem is that the ingredients needed to make RNA World work just didn’t exist on early Earth.

A 15-year effort points to treatments to help MacTel patients and offers potential new insights into other eye diseases.

A new method for making valuable compounds known as “hindered ethers” significantly improves production yield while reducing expense and reaction steps.

Rather than continue to dig for clues on what drives relapse among those who struggle with compulsive drug use, a Scripps Research team explored how the brain responds to environmental cues that suppress cravings.

Scientists at Scripps Research have discovered what may be the earliest possible biological marker of type 1 diabetes, formerly known as juvenile diabetes.

A genomics study of travel-associated Zika cases reveals an undiscovered outbreak in Cuba in 2017, underscoring the need for coordinated disease surveillance.

A new study reveals how proteins from the eye’s nerve cells relay visual cues to different parts of the brain.