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Hepatocytes, long known deactivating chemical toxins in the blood, should also be viewed as a significant element of the immune system. 

The discovery marks a key advance in basic neurobiology and may lead to better treatments for bladder control and urination problems.

A new study clarifies how a key chemical engine of life might have arisen from simple organic compounds on early Earth.

A mouse study on the brain’s striatum region reveals an unexpected but important finding.

Assistant Professors Huan Bao, Lisa Racki and Li Ye have been awarded grants through an NIH program that seeks to catalyze scientific discovery by supporting research with transformative potential.   

The therapy is currently being evaluated as a treatment for B-cell malignancies, a class of blood cancers that includes non-Hodgkin’s lymphoma and chronic lymphocytic leukemia.

A sweeping study of proteins that modulate cell signaling could lead to a better understanding of myriad diseases, and of what makes us all different.

The virus that causes COVID-19 uses a clutch-like shifter to enable transcription of one RNA string into multiple proteins, and therein lies a vulnerability. A proof-of-concept study from Disney lab shows it’s possible to eliminate that shifter with an RNA-binding medicinal compound linked to a “trash this” signal.

Early detection of atrial fibrillation can help significantly reduce the risk of stroke, and digital health tools may be the answer.

Discoveries from Boger’s lab have led to unique strategies and methods for making molecules, as well as durable antibiotics, novel ways to treat chronic pain, and an experimental cancer vaccine.

The novel vaccine technology, developed at Scripps Research, uses virus-like particles to elicit high levels of protective antibodies.

Several mutant forms of NEMF in mice interfered with ribosome-associated quality control and resulted in neuromuscular, neurodegenerative or other disease.

Wearable devices give scientists a powerful new tool for sleep studies.

In a new study, Scripps Research scientists pave the way toward creating a medicinal compound that imitates the valuable effects of reduced body temperature.

A fundamental neuroscience discovery may propel future efforts to boost vision lost due to retina degeneration and enable light-sensing prosthetics that cure blindness.

Scientists in the United States and West Africa to develop research network to rapidly respond to current and future infectious disease outbreaks.

Damaged hearts require stem cell activation to heal, but heart attack silences a key signaling molecule. A compound discovered in Disney lab reactivates its production, in cell-based studies. 

Shenvi and Roberts are recognized for their contributions in organic synthesis and the development of medicinally useful substances.

A small molecule that activates the immune protein STING shows promising results against tumors.

These molecules, called terpenes, are potential starting points for new drugs and other high-value products, marking an important development for multiple industries.

Electron microscopy showed that the coronavirus spikes maintained the desired shape in the vaccine, which should help stimulate an appropriate immune response.

Unlike traditional vaccine clinical trials, this study provided a clear and comprehensive picture of a vaccine’s antibody-response landscape.

Collaborating labs at Scripps Research developed a way to seamlessly create the compound's complex structure.

Chemists at Scripps Research have reported a promising but mysterious finding in experiments with a potential vaccine that is meant to combat heroin addiction.