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Where hypotheses become headlines: Featured coverage of the breakthroughs—and the people—driving our research forward

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The Scripps Research scientists leading the Huang Foundation-supported projects. From left: Terrence Messmer, Sarah Burbach, Matthew Holcomb, Bryan Briney, Stefano Forli, Benjamin Cravatt, Christopher Parker, Andrew Ward and Charles Bowman.
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Scripps Research garners major support for AI innovations in biomedicine with compute grant from Jen-Hsun and Lori Huang Foundation

Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

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  • Enzyme discovery is missing piece in understanding how to rein in blood vessels that fuel cancer
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    Enzyme discovery is missing piece in understanding how to rein in blood vessels that fuel cancer

    The findings may enable better cancer treatments and new interventions for heart disease.

  • Experimental vaccine can counter dangerous effects of synthetic cannabinoids
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    Experimental vaccine can counter dangerous effects of synthetic cannabinoids

    Made in clandestine laboratories and sold widely across the United States, the diverse class of drugs known as synthetic cannabinoids presents a growing public health threat.

  • Potential treatment approach kills lymphoma while sparing healthy cells
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    Potential treatment approach kills lymphoma while sparing healthy cells

    The strategy relies on natural cancer-targeting cells of the immune system, called natural killer cells, that have been modified to selectively target lymphoma cells.

  • ‘Functionalized fragments’ help design RNA medicines for undruggable diseases
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    ‘Functionalized fragments’ help design RNA medicines for undruggable diseases

    A new tool enables scientists to tackle difficult molecular recognition problems to aid drug discovery for incurable diseases.

  • Scripps Research names Jin-Quan Yu to newly-endowed Bristol Myers Squibb Chair in Chemistry
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    Scripps Research names Jin-Quan Yu to newly-endowed Bristol Myers Squibb Chair in Chemistry

    A pioneering chemist, Yu's research has paved the way to powerful new techniques used in fields ranging from drug discovery to materials science.

  • Hidden network of enzymes accounts for loss of brain synapses in Alzheimer’s
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    Hidden network of enzymes accounts for loss of brain synapses in Alzheimer’s

    The discovery of abnormal chemical reactions may lead to novel targets for drugs that treat neurodegenerative diseases.

  • Study highlights strategies for boosting accuracy of personal genetic risk scores
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    Study highlights strategies for boosting accuracy of personal genetic risk scores

    More consumers are turning to quick DNA tests to learn their disease risks, but the scores they receive aren't always as precise as they could be.

  • Scripps Research scientists capture 15 spots on ranking of most highly cited researchers
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    Scripps Research scientists capture 15 spots on ranking of most highly cited researchers

    The researchers on the 2020 list rank in the top 1 percent of citations in their field over the prior decade, as measured by Web of Science, world’s largest publisher-neutral citation index.

  • Engineered immune cells elicit broad response to HIV in mice, offering hope for vaccine or functional cure
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    Engineered immune cells elicit broad response to HIV in mice, offering hope for vaccine or functional cure

    Scientists developed an approach that successfully generates antibodies against numerous strains of the fast-evolving human immunodeficiency virus.

    James Voss
  • Chronic alcohol use reshapes the brain’s immune landscape, driving anxiety and addiction
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    Chronic alcohol use reshapes the brain’s immune landscape, driving anxiety and addiction

    In their quest to understand how the immune system is implicated in alcohol use disorder, Scripps Research scientists have found a potential path for treatment. 

  • Scientists and public health officials use genomics to understand how COVID-19 spreads in San Diego, neighboring regions
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    Scientists and public health officials use genomics to understand how COVID-19 spreads in San Diego, neighboring regions

    With funding from the Centers for Disease Control and Prevention, scientists at Scripps Research and UC San Diego are sequencing the virus to help guide local outbreak response.

  • Two-birds-one-stone strategy shows promise in RNA-repeat expansion diseases
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    Two-birds-one-stone strategy shows promise in RNA-repeat expansion diseases

    A compound designed at Scripps Research works in early tests against myotonic dystrophy 1 and Fuchs endothelial corneal dystrophy, which together affect millions of people.

  • Early results from DETECT study suggest fitness trackers and smartwatches can predict COVID-19 infection
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    Early results from DETECT study suggest fitness trackers and smartwatches can predict COVID-19 infection

    Sensor data from wearable devices can complement virus testing and conventional screening to signal new infections.

  • New strategy for treating common retinal diseases shows promise
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    New strategy for treating common retinal diseases shows promise

    Scientists have uncovered a potential new approach for treating eye diseases that affect millions of people around the world. 

  • Society for Neuroscience recognizes Courtney Miller for advocacy efforts
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    Society for Neuroscience recognizes Courtney Miller for advocacy efforts

    The Louise Hanson Marshall Award honors individuals who significantly promoted the professional development of women in neuroscience.

  • Antibodies co-invented by Scripps Research and IAVI to be developed as a potential COVID-19 therapy
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    Antibodies co-invented by Scripps Research and IAVI to be developed as a potential COVID-19 therapy

    The monoclonal antibody treatment will be tested in clinical trials, with the goal of reaching patients around the world, including in low- and middle-income countries.    

  • PTSD and alcohol abuse go hand-in-hand, but males and females exhibit symptoms differently
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    PTSD and alcohol abuse go hand-in-hand, but males and females exhibit symptoms differently

    In rodent experiments modeled to mimic real-life circumstances, scientists revealed brain mechanisms that could lead to targeted treatments. 

  • New imaging method reveals HIV’s sugary shield in unprecedented detail
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    New imaging method reveals HIV’s sugary shield in unprecedented detail

    The technique should help in the design of vaccines against HIV, SARS-CoV-2 and other viruses that cloak their outer proteins with sugars to evade antibodies.

  • San Diego research community: ICE proposal threatens scientific progress
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    San Diego research community: ICE proposal threatens scientific progress

    Leaders from area’s top biomedical research institutes unite in outlining potentially negative impact of proposal, if implemented, on international scholars and scientific progress.

  • Rapid method of isolating tumor-targeting T cells could propel personalized cancer treatments
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    Rapid method of isolating tumor-targeting T cells could propel personalized cancer treatments

    The technique seeks to fill an unmet need among scientists and doctors who need faster, more precise tools to identify useful tumor-infiltrating immune cells.

  • Chemists develop framework to enable efficient synthesis of ‘information-dense’ molecules
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    Chemists develop framework to enable efficient synthesis of ‘information-dense’ molecules

    Researchers harness information theory to better understand how to make complex and compact molecules resembling those in nature.

  • Feedback loop within intestinal cells may explain why prolonged fat-burning doesn’t diminish longevity
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    Feedback loop within intestinal cells may explain why prolonged fat-burning doesn’t diminish longevity

    In studies involving roundworms, Scripps Research scientists discover a cellular process that may hold implications for treating metabolic diseases.

  • Gene linked to autism and epilepsy directs speed of human brain cell development
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    Gene linked to autism and epilepsy directs speed of human brain cell development

    A gene associated with autism is found to direct the speed at which neurons mature.

  • Immune activation in the liver illuminated with new glycan-tagging strategy
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    Immune activation in the liver illuminated with new glycan-tagging strategy

    A signaling system implicated in liver fibrosis and immune activation is better understood thanks to this creative chemical fishing lure.

Groundbreaking Science.
Life-changing Medicine.