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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • Scripps Research scientists capture 15 spots on ranking of most highly cited researchers
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    Scripps Research scientists capture 15 spots on ranking of most highly cited researchers

    The researchers on the 2020 list rank in the top 1 percent of citations in their field over the prior decade, as measured by Web of Science, world’s largest publisher-neutral citation index.

  • Engineered immune cells elicit broad response to HIV in mice, offering hope for vaccine or functional cure
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    Engineered immune cells elicit broad response to HIV in mice, offering hope for vaccine or functional cure

    Scientists developed an approach that successfully generates antibodies against numerous strains of the fast-evolving human immunodeficiency virus.

    James Voss
  • Chronic alcohol use reshapes the brain’s immune landscape, driving anxiety and addiction
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    Chronic alcohol use reshapes the brain’s immune landscape, driving anxiety and addiction

    In their quest to understand how the immune system is implicated in alcohol use disorder, Scripps Research scientists have found a potential path for treatment. 

  • Scientists and public health officials use genomics to understand how COVID-19 spreads in San Diego, neighboring regions
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    Scientists and public health officials use genomics to understand how COVID-19 spreads in San Diego, neighboring regions

    With funding from the Centers for Disease Control and Prevention, scientists at Scripps Research and UC San Diego are sequencing the virus to help guide local outbreak response.

  • Two-birds-one-stone strategy shows promise in RNA-repeat expansion diseases
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    Two-birds-one-stone strategy shows promise in RNA-repeat expansion diseases

    A compound designed at Scripps Research works in early tests against myotonic dystrophy 1 and Fuchs endothelial corneal dystrophy, which together affect millions of people.

  • Early results from DETECT study suggest fitness trackers and smartwatches can predict COVID-19 infection
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    Early results from DETECT study suggest fitness trackers and smartwatches can predict COVID-19 infection

    Sensor data from wearable devices can complement virus testing and conventional screening to signal new infections.

  • New strategy for treating common retinal diseases shows promise
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    New strategy for treating common retinal diseases shows promise

    Scientists have uncovered a potential new approach for treating eye diseases that affect millions of people around the world. 

  • Society for Neuroscience recognizes Courtney Miller for advocacy efforts
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    Society for Neuroscience recognizes Courtney Miller for advocacy efforts

    The Louise Hanson Marshall Award honors individuals who significantly promoted the professional development of women in neuroscience.

  • Antibodies co-invented by Scripps Research and IAVI to be developed as a potential COVID-19 therapy
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    Antibodies co-invented by Scripps Research and IAVI to be developed as a potential COVID-19 therapy

    The monoclonal antibody treatment will be tested in clinical trials, with the goal of reaching patients around the world, including in low- and middle-income countries.    

  • PTSD and alcohol abuse go hand-in-hand, but males and females exhibit symptoms differently
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    PTSD and alcohol abuse go hand-in-hand, but males and females exhibit symptoms differently

    In rodent experiments modeled to mimic real-life circumstances, scientists revealed brain mechanisms that could lead to targeted treatments. 

  • New imaging method reveals HIV’s sugary shield in unprecedented detail
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    New imaging method reveals HIV’s sugary shield in unprecedented detail

    The technique should help in the design of vaccines against HIV, SARS-CoV-2 and other viruses that cloak their outer proteins with sugars to evade antibodies.

  • San Diego research community: ICE proposal threatens scientific progress
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    San Diego research community: ICE proposal threatens scientific progress

    Leaders from area’s top biomedical research institutes unite in outlining potentially negative impact of proposal, if implemented, on international scholars and scientific progress.

  • Rapid method of isolating tumor-targeting T cells could propel personalized cancer treatments
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    Rapid method of isolating tumor-targeting T cells could propel personalized cancer treatments

    The technique seeks to fill an unmet need among scientists and doctors who need faster, more precise tools to identify useful tumor-infiltrating immune cells.

  • Chemists develop framework to enable efficient synthesis of ‘information-dense’ molecules
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    Chemists develop framework to enable efficient synthesis of ‘information-dense’ molecules

    Researchers harness information theory to better understand how to make complex and compact molecules resembling those in nature.

  • Feedback loop within intestinal cells may explain why prolonged fat-burning doesn’t diminish longevity
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    Feedback loop within intestinal cells may explain why prolonged fat-burning doesn’t diminish longevity

    In studies involving roundworms, Scripps Research scientists discover a cellular process that may hold implications for treating metabolic diseases.

  • Gene linked to autism and epilepsy directs speed of human brain cell development
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    Gene linked to autism and epilepsy directs speed of human brain cell development

    A gene associated with autism is found to direct the speed at which neurons mature.

  • Immune activation in the liver illuminated with new glycan-tagging strategy
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    Immune activation in the liver illuminated with new glycan-tagging strategy

    A signaling system implicated in liver fibrosis and immune activation is better understood thanks to this creative chemical fishing lure.

  • Study shows main cell type in the liver has key role in defending against some viruses
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    Study shows main cell type in the liver has key role in defending against some viruses

    Hepatocytes, long known deactivating chemical toxins in the blood, should also be viewed as a significant element of the immune system. 

    Immunology & Microbiology J. Lindsay Whitton
  • Scientists identify sensor protein that underlies bladder control
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    Scientists identify sensor protein that underlies bladder control

    The discovery marks a key advance in basic neurobiology and may lead to better treatments for bladder control and urination problems.

  • Origin-of-life chemists discover plausible ancestor of essential metabolic process used by most plants and animals
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    Origin-of-life chemists discover plausible ancestor of essential metabolic process used by most plants and animals

    A new study clarifies how a key chemical engine of life might have arisen from simple organic compounds on early Earth.

  • Dangerous side effect of widely used psychiatric drug may be treatable with existing medicine
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    Dangerous side effect of widely used psychiatric drug may be treatable with existing medicine

    A mouse study on the brain’s striatum region reveals an unexpected but important finding.

    Neuroscience Srinivasa Subramaniam
  • 3 Scripps Research scientists win NIH New Innovator Award for ‘high-risk, high-reward’ projects
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    3 Scripps Research scientists win NIH New Innovator Award for ‘high-risk, high-reward’ projects

    Assistant Professors Huan Bao, Lisa Racki and Li Ye have been awarded grants through an NIH program that seeks to catalyze scientific discovery by supporting research with transformative potential.   

  • FDA grants Fast Track designation to Calibr’s ‘switchable’ CAR-T cell cancer therapy, CLBR001 + SWI019
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    FDA grants Fast Track designation to Calibr’s ‘switchable’ CAR-T cell cancer therapy, CLBR001 + SWI019

    The therapy is currently being evaluated as a treatment for B-cell malignancies, a class of blood cancers that includes non-Hodgkin’s lymphoma and chronic lymphocytic leukemia.

  • Why do people respond differently to the same drug?
    News

    Why do people respond differently to the same drug?

    A sweeping study of proteins that modulate cell signaling could lead to a better understanding of myriad diseases, and of what makes us all different.

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