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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award
Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart
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    New TSRI Study Shows Early Brain Changes in Fragile X Syndrome

    A new study led by scientists at Scripps Research is giving researchers a first look at the early stages of brain development in patients with Fragile X syndrome.

    Translational Medicine Stem Cell Research
  • TSRI Scientists Find Brain Hormone that Triggers Fat Burning
    News

    TSRI Scientists Find Brain Hormone that Triggers Fat Burning

    Biologists at The Scripps Research Institute (TSRI) have identified a brain hormone that appears to trigger fat burning in the gut.

    Neuroscience
  • News

    Scripps Florida Team Awarded $1.8 Million Grant to Develop Drugs for Heart Disease and Rheumatoid Arthritis

    The co-principal investigators of the three-year project are TSRI Professor William R. Roush and Associate Professor Derek Duckett.

    Chemistry Grants New Therapies
  • TSRI Scientists Create First Stable Semisynthetic Organism
    News

    TSRI Scientists Create First Stable Semisynthetic Organism

    Life’s genetic code has only ever contained four natural bases. Until now.
  • News

    TSRI Scientists Show Deep Brain Stimulation Blocks Heroin Relapse in Rats

    "These results also suggest new insights into the neurocircuitry of heroin addiction."

    Neuroscience
  • New TSRI Method Could Turbocharge Drug Discovery, Protein Research
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    New TSRI Method Could Turbocharge Drug Discovery, Protein Research

    A team led by scientists at Scripps Research has developed a versatile new method that should enhance the discovery of new drugs and the study of proteins.

    Chemistry New Technologies New Therapies
  • The Scripps Research Institute Signs Collaboration Agreement with Pfizer to Advance DNA-Encoded Library Technology
    News

    The Scripps Research Institute Signs Collaboration Agreement with Pfizer to Advance DNA-Encoded Library Technology

    The Scripps Research Institute (TSRI), a leading non-profit biomedical research institute, today announced a research collaboration and license agreement with Pfizer Inc. (NYSE: PFE) to pioneer new DNA-encoded library (DEL) technology.

    Chemistry Institute News New Therapies
  • News

    Calibr News: Intarcia and Calibr Announce New Collaboration and In-Licensing Deal

    Calibr, a corporate affiliate of The Scripps Research Institute, has announced a strategic research collaboration with Intarcia Therapeutics, Inc.

    Institute News New Therapies
  • News

    TSRI Researchers Discover Surprising Process Behind Sense of Touch

    Biologists on the Florida campus of Scripps Research have discovered a new mechanism that likely underlies how we feel force or touch.

    Scott Hansen
  • News

    Scripps Florida Scientists Expand Toolbox to Study Cellular Function

    "I think we’re on the brink of an explosion of new tools for mass spectrometry."

    Chemistry
  • News

    TSRI Scientists Take Step Toward Mapping How the Brain Stores Memories

    The research, published recently in the journal eLife, is the first to demonstrate that the same brain region can both motivate a learned behavior and suppress that same behavior.

    Neuroscience Nobuyoshi Suto
  • News

    Scripps Florida Scientists Develop Drug Discovery Approach to Predict Health Impact of Endocrine-Disrupting Chemicals

    Integrative Structural & Computational Biology
  • TSRI Study: Protein Monitors Lung Volume and Regulates Breathing
    News

    TSRI Study: Protein Monitors Lung Volume and Regulates Breathing

    Neuroscience
  • News

    Scripps Florida Scientists Uncover Cellular Process Behind Premature Aging
  • News

    Scripps Florida Scientist Awarded $5 Million Outstanding Investigator Grant to Study the Biology of Memory

    Neuroscience
  • Scripps Florida Scientists Discover New Natural Source of Potent Anti-Cancer Drugs
    News

    Scripps Florida Scientists Discover New Natural Source of Potent Anti-Cancer Drugs

    Immunology & Microbiology Chemistry
  • TSRI Scientists Show How Drug Binds with ‘Hidden Pocket’ on Flu Virus
    News

    TSRI Scientists Show How Drug Binds with ‘Hidden Pocket’ on Flu Virus

    Integrative Structural & Computational Biology
  • News

    ‘Western’ Maternal Diet Appears to Raise Obesity Risk in Offspring

    Translational Medicine
  • News

    TSRI Scientists Devise New Approaches to Personalized Medicines

    Chemistry Individualized Medicine New Therapies
  • News

    Ancient Enzyme Morphed Shape to Carry Out New Functions in Humans

    Integrative Structural & Computational Biology
  • News

    Scripps Florida Scientists Uncover Potential Driver of Age- and Alzheimer’s-Related Memory Loss

    Neuroscience Srinivasa Subramaniam
  • News

    TSRI Scientists Find Mechanism Behind Side Effects in Vision-Loss Treatment

    Molecular & Cellular Biology Genomics
  • News

    Scripps Florida Scientists Identify Novel Compound to Alleviate Pain and Itch While Avoiding Common Side Effects

    Neuroscience
  • News

    TSRI Scientists Develop Vaccine Against Fatal Prescription Opioid Overdose

    Chemistry
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