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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • Influenza Virus Can Overcome Potentially Crippling Mutations
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    Influenza Virus Can Overcome Potentially Crippling Mutations

    New research could improve the effectiveness of flu vaccines and therapies

  • Scientists Solve a Mystery in Cellular “Droplet” Organelles
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    Scientists Solve a Mystery in Cellular “Droplet” Organelles

    Scientists at Scripps Research have solved a cellular mystery that may have important implications for fundamental biology and diseases like ALS.

  • The Scripps Research Institute and ShangPharma Innovation Announce Translational Research Collaboration
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    The Scripps Research Institute and ShangPharma Innovation Announce Translational Research Collaboration

    World-class research institute and new innovation center partner to accelerate early translational research.

  • News

    Anti-Heroin Vaccine Found Effective in Non-Human Primates

    The next step in this research will be to license the vaccine to an outside company for partnering in clinical trials.

  • News

    Scripps Florida Scientist Named Finalist for Blavatnik National Awards for Young Scientists

    Matthew Disney is a finalist for the prestigious Blavatnik National Awards for Young Scientists.

  • Perseverance Pays Off in Fight Against Deadly Lassa Virus
    News

    Perseverance Pays Off in Fight Against Deadly Lassa Virus

    "This was a tenacious effort—over a decade—to conquer a global threat."

  • News

    The Scripps Research Institute Appoints Alexandria Real Estate Equities, Inc. CEO Joel Marcus to Board of Directors

    "Joel’s professional experience and business leadership add to the expertise of our current board members."

  • News

    Scripps Florida Scientist Wins $2 Million Grant to Study Childhood Disorder Linked to Behavioral Problems

    Assistant Professor Seth Tomchik of the Florida campus of The Scripps Research Institute (TSRI) has received $2 million in funding from the National Institutes of Health’s National Institute of Neurological Disorders and Stroke (NINDS).

  • Scientists Jump Hurdle in HIV Vaccine Design
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    Scientists Jump Hurdle in HIV Vaccine Design

    Like a flu vaccine, an effective HIV vaccine needs to protect against multiple strains.

  • New Antibiotic Packs a Punch Against Bacterial Resistance
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    New Antibiotic Packs a Punch Against Bacterial Resistance

    Scientists at Scripps Research have given new superpowers to a lifesaving antibiotic called vancomycin, an advance that could eliminate the threat of antibiotic-resistant infections for years to come.

  • TSRI Scientists Find Simple Copper Complex Shuts Down Botulinum Neurotoxin Poisoning
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    TSRI Scientists Find Simple Copper Complex Shuts Down Botulinum Neurotoxin Poisoning

    A discovery by scientists at Scripps Research may provide a new therapy that can stop the neurotoxin even in its more severe, advanced stages of action.

  • Zika Reached Miami at Least Four Times, Caribbean Travel Likely Responsible
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    Zika Reached Miami at Least Four Times, Caribbean Travel Likely Responsible

    With mosquito season looming in the Northern Hemisphere, doctors and researchers are poised to take on a new round of Zika virus infections.

  • News

    New Equipment at Scripps Florida Will Advance Drug Discovery

    The Nuclear Magnetic Resonance (NMR) facility at the Florida campus of Scripps Florida is becoming one of the most advanced in South Florida, thanks to a new $600,000 grant from the National Institutes of Health.

  • Scientific Trailblazers to Address Historic Graduating Class at TSRI
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    Scientific Trailblazers to Address Historic Graduating Class at TSRI

    Scripps Research Graduate Program Marks 25th Commencement with Two Honorary Degree Recipients

  • News

    Three San Diego Researchers Honored by Royal Society of Chemistry

    Three chemists from Scripps Research—Dale Boger, Jin-Quan Yu and Phil Baran—have received awards from the Royal Society of Chemistry.

  • Scientists Solve Major Cancer Protein Conundrum
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    Scientists Solve Major Cancer Protein Conundrum

    “Since this is a major pathway for diseases like cancer and fibrosis, our findings add a brand-new layer of valuable information."

  • At Last, a Clue to Where Cancer Metastases Are Born
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    At Last, a Clue to Where Cancer Metastases Are Born

    Scientists at Scripps Research have discovered why some cancers may reoccur after years in remission.

  • News

    Two TSRI Scientists Elected to the National Academy of Sciences

    San Diego researchers Ardem Patapoutian and Phil Baran receive one of science’s highest honors

  • News

    Scientists Unravel How Protein Impacts Intellectual Disability

    Scientists from the Florida campus of Scripps Research have shown that a protein helps balance nerve cell communication.

  • News

    HitGen Announces Drug Discovery Collaboration with the Scripps Research Institute and the California Institute for Biomedical Research (Calibr)

    Leaders in basic and translational research at TSRI and Calibr will provide target materials and relevant know‐how to prosecute drug targets of interest.

  • Massive Chromosome Fusions? Neurons Don’t Care
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    Massive Chromosome Fusions? Neurons Don’t Care

    Brain cells appear less vulnerable to DNA damage than previously thought, according to a new study led by scientists at Scripps Research.

  • Closer Look at Brain Circuits Reveals Important Role of Genetics
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    Closer Look at Brain Circuits Reveals Important Role of Genetics

    Scientists at Scripps Research in La Jolla have revealed new clues to the wiring of the brain.

  • Broad Advance from TSRI Chemists Dramatically Simplifies Olefin Synthesis
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    Broad Advance from TSRI Chemists Dramatically Simplifies Olefin Synthesis

    New method expected to replace textbook reactions, enable syntheses of many new candidate drugs and other molecules.

  • Co-authors of the study hold the ingredients to successfully carry out the new method. Left to right: David Peters, Ming Yan, Jie Wang, Chao Li and Lisa Barton. (Photo by Madeline McCurry-Schmidt.)
    News

    Chemists Devise Simple Method for Making Sought-After Boronic Acid-Based Drugs and Other Products

    Initial demonstrations yield compounds with promise for treating COPD, cystic fibrosis and other lung disorders.

Groundbreaking Science.
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