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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • Is nature’s 20 amino acid genetic code optimal-evolving proteins using an expanded genetic code?
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    Is nature’s 20 amino acid genetic code optimal-evolving proteins using an expanded genetic code?

    Scripps Research scientists direct bacteria with expanded genetic code to evolve extreme heat tolerance.

  • News

    On the trail of rare genetic disease, scientists uncover key immune regulator

    Scientists at Scripps Research have found an important immune system-regulating protein that in principle could be targeted to treat cancers and chronic viral infections.

    Virology
  • Scripps Research scientists unveil promising new HIV vaccine strategy
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    Scripps Research scientists unveil promising new HIV vaccine strategy

    A new candidate HIV vaccine from Scripps Research surmounts technical hurdles that stymied previous vaccine efforts, and stimulates a powerful anti-HIV antibody response in animal tests.

  • Families aid discovery of a sensory-processing disorder gene in children with autism traits
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    Families aid discovery of a sensory-processing disorder gene in children with autism traits

    A concerned Texas mom finally has answers about the cause of her son’s sensory-processing problems thanks to a special collaboration among her patient-advocacy group and the lab of Scripps Research Neuroscientist Gavin Rumbaugh, PhD.

  • Scripps Research scientists decode mechanism of remembering—and forgetting
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    Scripps Research scientists decode mechanism of remembering—and forgetting

    It’s a common expression to say that your brain is full. Although the brain doesn’t literally fill up, in recent years researchers have discovered that the brain does sometimes push out old memories in order to take up new ones.

  • Florida Outstanding Mentor blends stoicism and intensity to advance his field
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    Florida Outstanding Mentor blends stoicism and intensity to advance his field

    The Society of Research Fellows at Scripps Research in Florida named chemist Hans Renata, PhD, the Outstanding Mentor for 2018 in recognition of his dedication to his students and postdoctoral fellows. Renata’s lab members say he embodies both patience and high expectations.

  • Scripps Research licenses urine dipstick test for river blindness to IVD Research
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    Scripps Research licenses urine dipstick test for river blindness to IVD Research

    IVD Research Inc., a contract development and manufacturing (CDMO)  firm in Carlsbad, California has licensed a novel biomarker for onchocerciasis—better known as river blindness—from Scripps Research in La Jolla, California. The reagent, developed in the laboratory of Kim Janda, PhD, a professor of chemistry at Scripps Research, will allow clinicians to monitor active infections of onchocerciasis.

  • Scientists find mysterious family of proteins are cellular pressure sensors
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    Scientists find mysterious family of proteins are cellular pressure sensors

    Scientists at Scripps Research have discovered that a mysterious family of cellular proteins called OSCAs and TMEM63s are a novel class of mechanosensitive ion channels.

  • The Scripps Fellows Program
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    The Scripps Fellows Program

    Scripps Research enjoys a worldwide reputation for producing innovative, high-quality research. Now, the institute’s Scripps Fellows program is identifying the next generation of scientific leaders and setting them up to launch impactful careers.

  • News

    Shape-shifting ribosomes ‘tune’ the cellular response to stress

    When ribosomes malfunction, disease is not far behind.

  • Tethered antibodies present a potential new approach to prevent influenza virus infections all season long
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    Tethered antibodies present a potential new approach to prevent influenza virus infections all season long

    This is the first time four antibodies have been tethered together and tried against influenza.

  • News

    Scientists find potential path for countering oxidative stress in a range of diseases

    Scientists at Scripps Research have made a surprising discovery in their mission to understand how cells stay healthy, uncovering an important connection between a cell’s sugar metabolism and its antioxidant response.

  • Scripps Research awarded $3.3 million grant to study brain circuitry
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    Scripps Research awarded $3.3 million grant to study brain circuitry

    The funding will support research in the Stowers lab to describe a complete neural circuit in a mammalian brain—a first for science.

  • Solving a 100-year mystery in blood pressure research
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    Solving a 100-year mystery in blood pressure research

    New insight into how cells sense blood pressure could present better targets for treating hypertension.

  • Synthetic microorganisms allow scientists to study ancient evolutionary mysteries in the laboratory
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    Synthetic microorganisms allow scientists to study ancient evolutionary mysteries in the laboratory

    Scripps Research scientists use the tools of synthetic biology to engineer organisms similar to those thought to have lived billions of years ago

  • Scripps Research Translational Institute and NVIDIA partner to advance artificial intelligence in genomics and digital medicine
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    Scripps Research Translational Institute and NVIDIA partner to advance artificial intelligence in genomics and digital medicine

    The partnership seeks to accelerate the application of artificial intelligence for disease prevention, health promotion and the streamlining of biomedical research efforts.

  • Scientists capture images of antibodies working together against malaria
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    Scientists capture images of antibodies working together against malaria

    "It’s as if they link arms together to form a stronger complex..."

  • Engineered enzyme eliminates nicotine addiction in preclinical tests
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    Engineered enzyme eliminates nicotine addiction in preclinical tests

    Scientists at Scripps Research have successfully tested a potential new smoking-cessation treatment in rodents.

  • Jupiter Chemist Matthew Disney named BioFlorida’s Entrepreneur of the Year
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    Jupiter Chemist Matthew Disney named BioFlorida’s Entrepreneur of the Year

    Disney’s research has changed how scientists approach so-called “undruggable” diseases.

  • Researchers look beyond BMI to predict obesity-related disease risk
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    Researchers look beyond BMI to predict obesity-related disease risk

    Predictors of future diabetes and cardiovascular disease for a person with obesity can be found among their body's metabolites.

  • Team gets a closer look at how proteins meet on the cell membrane
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    Team gets a closer look at how proteins meet on the cell membrane

    New understanding of cell biology could give scientists a potential way to tackle cancer cells. 

  • PIEZO2, a molecular target for treating clinical pain
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    PIEZO2, a molecular target for treating clinical pain

    Researchers identify the protein responsible for allodynia, a kind of pain that follows gentle touch.

  • News

    Scripps Research creates Board of Overseers

    Founding members will help guide academic, scientific and business strategies.

  • Scripps Research Translational Institute welcomes academic nursing expert Lorraine Evangelista
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    Scripps Research Translational Institute welcomes academic nursing expert Lorraine Evangelista

    Lorraine S. Evangelista, PhD, RN, has joined the Scripps Research Translational Institute as associate scientific director for the All of Us Research Program’s Participant Center.

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