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Where hypotheses become headlines: Featured coverage of the breakthroughs—and the people—driving our research forward

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The Scripps Research scientists leading the Huang Foundation-supported projects. From left: Terrence Messmer, Sarah Burbach, Matthew Holcomb, Bryan Briney, Stefano Forli, Benjamin Cravatt, Christopher Parker, Andrew Ward and Charles Bowman.
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Scripps Research garners major support for AI innovations in biomedicine with compute grant from Jen-Hsun and Lori Huang Foundation

Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

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  • Scientists design antibody-studded cells to destroy cancer
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    Scientists design antibody-studded cells to destroy cancer

    Scripps Research scientists have developed a quick, cheap way to attach entire antibodies to living cells.

  • Scientists cut main heart disease risk locus out of DNA by genome editing
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    Scientists cut main heart disease risk locus out of DNA by genome editing

    Scripps Research scientists have made a major breakthrough in unveiling this medical mystery by precisely cutting the DNA culprit from the genome, which prevents blood vessel cell abnormalities related to these devastating diseases.

  • Is our DNA limited to four letters?
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    Is our DNA limited to four letters?

    Floyd Romesberg, PhD, a professor of chemistry at Scripps Research, proves it is not in his engaging TED talk.

  • Biologists show inner workings of cellular ‘undertaker’
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    Biologists show inner workings of cellular ‘undertaker’

    Scientists from Scripps Research deciphered how the proteasome converts energy into mechanical motion that untangles and unfolds proteins for destruction. The findings, published in Science, could help us understand how proteasomes keep diseases such as Parkinson’s and Alzheimer’s at bay.

    Integrative Structural & Computational Biology Alzheimer’s Disease Parkinson's Disease
  • Virologists at Scripps Research honored for scientific leadership, two share Gallo Award from the Global Virus Network
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    Virologists at Scripps Research honored for scientific leadership, two share Gallo Award from the Global Virus Network

    Michael B.A. Oldstone, MD, and Erica Ollmann Saphire, PhD were recognized by the Global Virus Network (GVN) for their leadership in the field of medical virology.

  • Memory strength dependent on abundance of ‘package’ deliveries, study shows
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    Memory strength dependent on abundance of ‘package’ deliveries, study shows

    Neurons communicate with each other by exchanging gifts — sending molecules back and forth across the synapse in tiny packages called synaptic vesicles. A team from Scripps Research has shown that the number of these vesicles, not only the number of synapses, plays an important role in how neurons share information. Moreover, increases in the number of vesicles at specific types of synapses lead to better memory formation.

  • Antibiotic could protect against neurodegenerative diseases during aging
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    Antibiotic could protect against neurodegenerative diseases during aging

    Scientists at Scripps Research have found that minocycline can increase the lifespan of roundworms by preventing the buildup of proteins during aging, according to a study in the open-access journal eLife reports.

  • Is nature’s 20 amino acid genetic code optimal-evolving proteins using an expanded genetic code?
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    Is nature’s 20 amino acid genetic code optimal-evolving proteins using an expanded genetic code?

    Scripps Research scientists direct bacteria with expanded genetic code to evolve extreme heat tolerance.

  • News

    On the trail of rare genetic disease, scientists uncover key immune regulator

    Scientists at Scripps Research have found an important immune system-regulating protein that in principle could be targeted to treat cancers and chronic viral infections.

    Virology
  • Scripps Research scientists unveil promising new HIV vaccine strategy
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    Scripps Research scientists unveil promising new HIV vaccine strategy

    A new candidate HIV vaccine from Scripps Research surmounts technical hurdles that stymied previous vaccine efforts, and stimulates a powerful anti-HIV antibody response in animal tests.

  • Families aid discovery of a sensory-processing disorder gene in children with autism traits
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    Families aid discovery of a sensory-processing disorder gene in children with autism traits

    A concerned Texas mom finally has answers about the cause of her son’s sensory-processing problems thanks to a special collaboration among her patient-advocacy group and the lab of Scripps Research Neuroscientist Gavin Rumbaugh, PhD.

  • Scripps Research scientists decode mechanism of remembering—and forgetting
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    Scripps Research scientists decode mechanism of remembering—and forgetting

    It’s a common expression to say that your brain is full. Although the brain doesn’t literally fill up, in recent years researchers have discovered that the brain does sometimes push out old memories in order to take up new ones.

  • Florida Outstanding Mentor blends stoicism and intensity to advance his field
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    Florida Outstanding Mentor blends stoicism and intensity to advance his field

    The Society of Research Fellows at Scripps Research in Florida named chemist Hans Renata, PhD, the Outstanding Mentor for 2018 in recognition of his dedication to his students and postdoctoral fellows. Renata’s lab members say he embodies both patience and high expectations.

  • Scripps Research licenses urine dipstick test for river blindness to IVD Research
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    Scripps Research licenses urine dipstick test for river blindness to IVD Research

    IVD Research Inc., a contract development and manufacturing (CDMO)  firm in Carlsbad, California has licensed a novel biomarker for onchocerciasis—better known as river blindness—from Scripps Research in La Jolla, California. The reagent, developed in the laboratory of Kim Janda, PhD, a professor of chemistry at Scripps Research, will allow clinicians to monitor active infections of onchocerciasis.

  • Scientists find mysterious family of proteins are cellular pressure sensors
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    Scientists find mysterious family of proteins are cellular pressure sensors

    Scientists at Scripps Research have discovered that a mysterious family of cellular proteins called OSCAs and TMEM63s are a novel class of mechanosensitive ion channels.

  • The Scripps Fellows Program
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    The Scripps Fellows Program

    Scripps Research enjoys a worldwide reputation for producing innovative, high-quality research. Now, the institute’s Scripps Fellows program is identifying the next generation of scientific leaders and setting them up to launch impactful careers.

  • News

    Shape-shifting ribosomes ‘tune’ the cellular response to stress

    When ribosomes malfunction, disease is not far behind.

  • Tethered antibodies present a potential new approach to prevent influenza virus infections all season long
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    Tethered antibodies present a potential new approach to prevent influenza virus infections all season long

    This is the first time four antibodies have been tethered together and tried against influenza.

  • News

    Scientists find potential path for countering oxidative stress in a range of diseases

    Scientists at Scripps Research have made a surprising discovery in their mission to understand how cells stay healthy, uncovering an important connection between a cell’s sugar metabolism and its antioxidant response.

  • Scripps Research awarded $3.3 million grant to study brain circuitry
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    Scripps Research awarded $3.3 million grant to study brain circuitry

    The funding will support research in the Stowers lab to describe a complete neural circuit in a mammalian brain—a first for science.

  • Solving a 100-year mystery in blood pressure research
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    Solving a 100-year mystery in blood pressure research

    New insight into how cells sense blood pressure could present better targets for treating hypertension.

  • Synthetic microorganisms allow scientists to study ancient evolutionary mysteries in the laboratory
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    Synthetic microorganisms allow scientists to study ancient evolutionary mysteries in the laboratory

    Scripps Research scientists use the tools of synthetic biology to engineer organisms similar to those thought to have lived billions of years ago

  • Scripps Research Translational Institute and NVIDIA partner to advance artificial intelligence in genomics and digital medicine
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    Scripps Research Translational Institute and NVIDIA partner to advance artificial intelligence in genomics and digital medicine

    The partnership seeks to accelerate the application of artificial intelligence for disease prevention, health promotion and the streamlining of biomedical research efforts.

  • Scientists capture images of antibodies working together against malaria
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    Scientists capture images of antibodies working together against malaria

    "It’s as if they link arms together to form a stronger complex..."

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