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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • Ozanimod accepted for priority review by FDA for the treatment of ulcerative colitis
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    Ozanimod accepted for priority review by FDA for the treatment of ulcerative colitis

    The priority review is based on results from a placebo-controlled Phase 3 trial evaluating ozanimod as a therapy for moderately to severely active ulcerative colitis.

  • Kenan Trust contributes $1.8 million to science education at Scripps Research, Florida
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    Kenan Trust contributes $1.8 million to science education at Scripps Research, Florida

    Scripps Research, Florida has received a $1.8 million philanthropic gift from the William R. Kenan, Jr. Charitable Trust to support science education training.

  • Unraveling the mystery of Gao, a protein implicated in movement disorders
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    Unraveling the mystery of Gao, a protein implicated in movement disorders

    Through their discovery, scientists expanded what's known about how the brain controls muscles and may have opened the door to potential treatments for children with certain rare disorders.

  • Toward safer steroids: Scientists devise process for making precision anti-inflammatory medicines
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    Toward safer steroids: Scientists devise process for making precision anti-inflammatory medicines

    Scripps Research scientists engineer potentially safer glucocorticoids, a group of drugs used to treat COVID-19, auto-immune disease, and many other conditions.

  • Harvard Business Review Op-ed: Planning for the Next Pandemic
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    Harvard Business Review Op-ed: Planning for the Next Pandemic

    Scripps Research President Peter Schultz calls for investment in the development of anti-viral drugs to combat viruses most likely to cause the next global pandemic.

  • Eric Topol to receive Gold Foundation medal for humanism in healthcare
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    Eric Topol to receive Gold Foundation medal for humanism in healthcare

    Topol to be honored alongside Drs. Anthony Fauci and Wayne Riley, as well as hundreds of healthcare professionals for their dedication and compassion during the COVID-19 crisis.  

  • Gene regulator pumps iron to control sleep, inflammation and more, study finds
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    Gene regulator pumps iron to control sleep, inflammation and more, study finds

    Structural studies reveal the role of an iron-rich molecule, heme, in bringing together gene transcription factors involved in sleep, immunity and metabolism.

  • Ardem Patapoutian receives 2021 Frontiers of Knowledge Award from BBVA
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    Ardem Patapoutian receives 2021 Frontiers of Knowledge Award from BBVA

    Patapoutian is recognized for world-class research that provided the molecular basis for how temperature and pressure are perceived.

  • At least 1 in 3 people infected with COVID-19 never develop symptoms, according to new analysis
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    At least 1 in 3 people infected with COVID-19 never develop symptoms, according to new analysis

    Findings suggest COVID-19 testing should be expanded to those without symptoms who may be unknowingly spreading the virus to others.

  • Scripps Research CEO Peter Schultz wins National Academy of Sciences’ chemistry award for extraordinary scientific achievements
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    Scripps Research CEO Peter Schultz wins National Academy of Sciences’ chemistry award for extraordinary scientific achievements

    Schultz has made many innovative and pioneering contributions to the interface between chemistry and biology, including the rational expansion of the genetic code. 

  • ‘Transient forgetting’ controlled by dopamine circuits, scientists find
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    ‘Transient forgetting’ controlled by dopamine circuits, scientists find

    Distraction can make you momentarily forget things. But how? Davis lab at Scripps Research, Florida uncovers a mechanism in fruit flies.

  • Answering the Big Questions with Science, Simplified
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    Answering the Big Questions with Science, Simplified

    How a graduate student’s scientific illustrations have gone viral, leading to an award-winning video series.

  • Scripps Research kicks off 2021 virtual Front Row lecture series
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    Scripps Research kicks off 2021 virtual Front Row lecture series

    Scripps Research President and CEO Peter Schultz, PhD, kicks off the 2021 Front Row lecture series with a talk on how the institute is accelerating drug development. 

    Events
  • Scripps Research, UC San Diego find first evidence of UK coronavirus variant in California
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    Scripps Research, UC San Diego find first evidence of UK coronavirus variant in California

    Since the team's discovery, several additional cases of the B.1.1.7 coronavirus variant have been identified across California.

  • Targeting muscle cells’ insulin receptors allows more efficient gene therapy
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    Targeting muscle cells’ insulin receptors allows more efficient gene therapy

    A new approach to gene therapy improves the efficiency of gene delivery.

  • How Scripps Research helped map the course for today’s COVID-19 vaccines
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    How Scripps Research helped map the course for today’s COVID-19 vaccines

    Structural biologists developed the first detailed images of the coronavirus spike protein and then created a way to stabilize the protein for vaccines.  

  • Discovery boosts theory that life on Earth arose from RNA-DNA mix
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    Discovery boosts theory that life on Earth arose from RNA-DNA mix

    In addition to addressing age-old questions on origin of life, the finding may lead to new practical applications in chemistry and biology.

  • Enzyme discovery is missing piece in understanding how to rein in blood vessels that fuel cancer
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    Enzyme discovery is missing piece in understanding how to rein in blood vessels that fuel cancer

    The findings may enable better cancer treatments and new interventions for heart disease.

  • Experimental vaccine can counter dangerous effects of synthetic cannabinoids
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    Experimental vaccine can counter dangerous effects of synthetic cannabinoids

    Made in clandestine laboratories and sold widely across the United States, the diverse class of drugs known as synthetic cannabinoids presents a growing public health threat.

  • Potential treatment approach kills lymphoma while sparing healthy cells
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    Potential treatment approach kills lymphoma while sparing healthy cells

    The strategy relies on natural cancer-targeting cells of the immune system, called natural killer cells, that have been modified to selectively target lymphoma cells.

  • ‘Functionalized fragments’ help design RNA medicines for undruggable diseases
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    ‘Functionalized fragments’ help design RNA medicines for undruggable diseases

    A new tool enables scientists to tackle difficult molecular recognition problems to aid drug discovery for incurable diseases.

  • Scripps Research names Jin-Quan Yu to newly-endowed Bristol Myers Squibb Chair in Chemistry
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    Scripps Research names Jin-Quan Yu to newly-endowed Bristol Myers Squibb Chair in Chemistry

    A pioneering chemist, Yu's research has paved the way to powerful new techniques used in fields ranging from drug discovery to materials science.

  • Hidden network of enzymes accounts for loss of brain synapses in Alzheimer’s
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    Hidden network of enzymes accounts for loss of brain synapses in Alzheimer’s

    The discovery of abnormal chemical reactions may lead to novel targets for drugs that treat neurodegenerative diseases.

  • Study highlights strategies for boosting accuracy of personal genetic risk scores
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    Study highlights strategies for boosting accuracy of personal genetic risk scores

    More consumers are turning to quick DNA tests to learn their disease risks, but the scores they receive aren't always as precise as they could be.

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