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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • New research consortium to tackle maternal health disparities with digital technologies
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    New research consortium to tackle maternal health disparities with digital technologies

    Mobile app-based research platform aims to engage and empower researchers and participants across the country.

  • Scripps Research mourns passing of pioneering scientist Richard Lerner
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    Scripps Research mourns passing of pioneering scientist Richard Lerner

    Lerner made major scientific contributions and built Scripps Research into a world-renowned hub of innovative science and medicine.

  • Search for safer pain relief advances with new engineered compounds
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    Search for safer pain relief advances with new engineered compounds

    New collection of pain relieving compounds dial down risk of tolerance and breathing suppression while boosting pain control.

  • Structure of depression-linked brain receptor solved, offering possible new treatment route
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    Structure of depression-linked brain receptor solved, offering possible new treatment route

    Chronic stress and depression boost this unusual brain receptor. A new study maps out its structure to aid drug discovery.

  • Scripps Research scientist Daniel Murin receives Katz Early Stage Investigator Award
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    Scripps Research scientist Daniel Murin receives Katz Early Stage Investigator Award

    The award supports an innovative project that represents an exciting change in research direction for an early stage investigator.

  • Two-antibody cocktail provides broad protection against ebolaviruses
    News

    Two-antibody cocktail provides broad protection against ebolaviruses

    Study shows how antibodies work in a powerful synergy against major ebolavirus species.

  • Scripps Research garners 17 places on global ranking of most highly cited researchers
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    Scripps Research garners 17 places on global ranking of most highly cited researchers

    The annual list represents the “who’s who” of influential researchers who have impacted their field over the past decade.

  • UF, Scripps Research green-light integration for Florida science powerhouse
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    UF, Scripps Research green-light integration for Florida science powerhouse

    An agreement has been signed to welcome the Florida branch of the science powerhouse into the research arm of UF’s academic health center.

  • From soapsuds to gold: Chemists develop powerful method for transforming simple, cheap chemicals into complex and valuable ones
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    From soapsuds to gold: Chemists develop powerful method for transforming simple, cheap chemicals into complex and valuable ones

    New method for desaturating aliphatic acids overcomes a long-standing challenge in synthetic chemistry.

  • New advance in modeling the chemistry of the origin of life
    News

    New advance in modeling the chemistry of the origin of life

    Study demonstrates a closely related set of chemical reactions that could have supported the development of early life forms.

  • Study reveals molecular pathway by which intense exercise promotes weight loss
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    Study reveals molecular pathway by which intense exercise promotes weight loss

    Boosting CRCT2 in mice counters metabolism-slowing effects of fasting, study finds.

  • Potential treatment for ALS, frontotemporal dementia targets RNA
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    Potential treatment for ALS, frontotemporal dementia targets RNA

    Compound co-opts a natural enzyme to degrade a deadly disease at its source, erasing 70 percent of a toxic protein in mice.

  • Fighting free radicals with finesse
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    Fighting free radicals with finesse

    A new chemistry tool offers hope for mitochondiral diseases.

  • New SARS-CoV-2 vaccine candidate shows great promise against variants of concern
    News

    New SARS-CoV-2 vaccine candidate shows great promise against variants of concern

    Study suggests the experimental vaccine may engage the immune system much more robustly than other vaccine strategies.

  • San Diego research centers receive $15 million to train next generation of regenerative medicines scientists
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    San Diego research centers receive $15 million to train next generation of regenerative medicines scientists

    Scripps Research and two other San Diego research institutions each received grants of around $5 million from CIRM to support the training of graduate students, postdoctoral trainees, and clinical trainees.

  • Early detection of atrial fibrillation with a wearable patch may help reduce strokes
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    Early detection of atrial fibrillation with a wearable patch may help reduce strokes

    3-year observational results of novel, home-based clinical trial published in PLOS ONE

    Translational Institute Steven Steinhubl
  • Scripps Research neuroscientist Ardem Patapoutian receives 2021 Nobel Prize in Physiology
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    Scripps Research neuroscientist Ardem Patapoutian receives 2021 Nobel Prize in Physiology

    Patapoutian is being recognized for his groundbreaking research that solved a long-standing mystery of how the body senses touch and other mechanical stimuli.

  • Scientists look to nature to discover method for installing sulfur into complex molecules
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    Scientists look to nature to discover method for installing sulfur into complex molecules

    Looking to nature to discover new ways to install sulfur into complex molecules.

  • Scripps Research scientists and student garner prestigious American Chemical Society awards
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    Scripps Research scientists and student garner prestigious American Chemical Society awards

    Recognition for scientific advancements benefitting humanity go to four Scripps Research scientists and a student.

  • Vision of expanded genetic code for making novel biologics comes closer to realization
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    Vision of expanded genetic code for making novel biologics comes closer to realization

    Expanding the genetic alphabet: Cells working with an expanded genetic code could make more diverse medicines. Scientists are within striking distance.

  • Computational biologists aim to solve science’s ‘scattered data’ problem with $7.5 million contract
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    Computational biologists aim to solve science’s ‘scattered data’ problem with $7.5 million contract

    Data ecosystem to be built for National Institute of Allergy and Infectious Diseases will give researchers a secure way to collaborate on research and medical advances.

    COVID-19
  • Wiring the brain to learn requires autism-linked gene
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    Wiring the brain to learn requires autism-linked gene

    Experience-dependent brain plasticity depends on this autism-linked gene.

  • Revving the ribosome
    News

    Revving the ribosome

    Scientists use directed evolution to boost ribosomes’ protein production, toward less costly protein therapies.

  • Flu discovery points to target for antiviral drugs
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    Flu discovery points to target for antiviral drugs

    Influenza A disables infected cells’ waste disposal process, presenting a vulnerability for antiviral drug discovery, a study finds.

Groundbreaking Science.
Life-changing Medicine.