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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • Scripps Research announces inaugural winners of Collaborative Innovation Fund
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    Scripps Research announces inaugural winners of Collaborative Innovation Fund

    The three winning teams receive grants to support highly innovative research focused on transforming catalysis, biological imaging, and our understanding of interorgan communication.

  • Scripps Research polysulfates could find wide use in high-performance electronics components
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    Scripps Research polysulfates could find wide use in high-performance electronics components

    Flexible compounds made with Nobel-winning click chemistry can be used in energy-storing capacitors at high temperatures and electric fields.

  • Scripps Research launches study to reduce hospitalization of immunocompromised people with COVID-19
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    Scripps Research launches study to reduce hospitalization of immunocompromised people with COVID-19

    In partnership with Cue Health, the study will deploy at-home COVID-19 tests, on-demand telemedicine and delivery of antiviral medication in an effort to lessen severe disease outcomes.

  • Scripps Research mourns loss of valued advisor and former board member Christopher Walsh
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    Scripps Research mourns loss of valued advisor and former board member Christopher Walsh

    A noted biochemist, Walsh had an enormous impact on academic research, drug discovery and the biopharmaceutical field.

  • Calibr advances multiple clinical programs while securing significant funding for global health and other disease initiatives
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    Calibr advances multiple clinical programs while securing significant funding for global health and other disease initiatives

    2022 year-end roundup: Clinical success and consistent funding validate Calibr’s pioneering approach to drug discovery.

  • Scripps Research study suggests insomnia drug could be repurposed for alcohol use disorder
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    Scripps Research study suggests insomnia drug could be repurposed for alcohol use disorder

    Orexin-receptor antagonist suvorexant (Belsomra®) reduced alcohol intake and blocked relapse in preclinical tests.

  • Fixing a misfolded protein to treat lung disease
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    Fixing a misfolded protein to treat lung disease

    A Scripps Research team discovered that a genetic lung disease can be fixed without correcting the mutated gene sequence—by controlling the way the corresponding protein folds to restore function.

  • Discovery could explain why women are more likely to get Alzheimer’s
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    Discovery could explain why women are more likely to get Alzheimer’s

    Scripps Research and MIT scientists find that a modified immune protein harming brain connections is much more common in the brains of women with Alzheimer’s, compared to men.

  • Structural studies offer “how-to” guide for designing cancer drugs
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    Structural studies offer “how-to” guide for designing cancer drugs

    By revealing how the structure of the PI3Kα protein changes in cancer cells, Scripps Research scientists point toward ways to target it with drugs.

  • Scripps Research chemists develop reactions for the general synthesis of promising unexplored compounds
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    Scripps Research chemists develop reactions for the general synthesis of promising unexplored compounds

    Family of compounds known as 1,2,3,5-tetrazines could have wide application in making new pharmaceuticals, chemical and biological probes, and other products.

  • Scientists reveal encouraging findings in first-in-human clinical trial evaluating HIV vaccine approach
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    Scientists reveal encouraging findings in first-in-human clinical trial evaluating HIV vaccine approach

    Scripps Research, IAVI, Fred Hutch, VRC and other collaborators publish study data in Science, helping validate novel vaccination strategy.

  • Nanotech strategy shows promise for treating autoimmune disease
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    Nanotech strategy shows promise for treating autoimmune disease

    In a Scripps Research study, a nanoparticle treatment ‘cured’ mice that had a genetic arthritis condition.

  • Can pharmacotherapies prevent alcohol use disorder in people with PTSD?
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    Can pharmacotherapies prevent alcohol use disorder in people with PTSD?

    A Scripps Research team showed how drugs can reduce alcohol preference in animal models of post-traumatic stress disorder.

  • Thirteen Scripps Research scientists featured on global list of most highly cited researchers
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    Thirteen Scripps Research scientists featured on global list of most highly cited researchers

    Thirteen scientists were named to Clarivate’s Highly Cited Researchers list: a methodology for identifying the most influential researchers from around the world.  

  • Person holding their wrist.
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    Picking the fastest progressing patients to speed Parkinson’s disease clinical trials

    A Scripps Research team developed a new tool that can predict how Parkinson’s disease patients will fare over the course of a year based on their genetics, brain scans and physical examinations. 

  • Discovery by Scripps Research scientists boosts the potential of new cancer-fighting drugs
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    Discovery by Scripps Research scientists boosts the potential of new cancer-fighting drugs

    Finding uncovers a key property needed for CELMoD drugs, a type of protein degrader, to work effectively.

  • Scripps Research receives $5.2M award to establish computer-aided drug discovery national resource
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    Scripps Research receives $5.2M award to establish computer-aided drug discovery national resource

    The five-year grant will support the development and distribution of innovative computational tools for advanced drug discovery.

  • Antibody blunts heroin’s lethality, paving the way for a promising new therapy
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    Antibody blunts heroin’s lethality, paving the way for a promising new therapy

    Scripps Research findings unexpectedly show that heroin, not its metabolites, is the best therapeutic target.

  • Scripps Research awarded NIH grant to enhance biosafety level 3 facility to address viruses of pandemic concern
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    Scripps Research awarded NIH grant to enhance biosafety level 3 facility to address viruses of pandemic concern

    The $3.8 million award will expand the institute’s research programs aimed at identifying therapeutics for various RNA viruses.

  • Scripps Research scientists map key protein structure of Hepatitis C virus
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    Scripps Research scientists map key protein structure of Hepatitis C virus

    Discovery points the way toward an effective HCV vaccine.

  • New tool reveals what happens in the brain when we learn
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    New tool reveals what happens in the brain when we learn

    A Scripps Research team measured how levels of various proteins in brain cells change in response to brain activity.

  • Drug discovery method identifies naturally occurring metabolite that converts ‘bad’ fat to ‘good’ fat
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    Drug discovery method identifies naturally occurring metabolite that converts ‘bad’ fat to ‘good’ fat

    Scripps Research and Calibr scientists collaborate to uncover potential therapeutic avenues for metabolic diseases.

  • Scripps Research receives $2.5M CDC contract for SARS-CoV-2 surveillance program
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    Scripps Research receives $2.5M CDC contract for SARS-CoV-2 surveillance program

    Work will include fast analyses of virus transmission in the San Diego area and across the U.S.- Mexico border.

  • Scripps Research professor K. Barry Sharpless receives 2022 Nobel Prize in Chemistry
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    Scripps Research professor K. Barry Sharpless receives 2022 Nobel Prize in Chemistry

    Sharpless awarded his second Nobel Prize in Chemistry–one of only two chemists to ever receive such an honor.

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