News

Scientists at Scripps Research found that apremilast (Otezla®) can reduce alcohol intake by more than half in people with severe alcohol use disorder.

Scripps Research scientists highlight the need for continued monitoring of SARS-CoV-2 and potential variants of concern. 

The discovery triggered development of a new potential drug to eliminate tumor formation.

Calibr transitions investigational compound CLB073 to Gates MRI to advance development.

Advance offers a new way of investigating diseases—including Alzheimer’s, Parkinson’s and different cancers—where mitochondria are disrupted.

Kelly receives the prestigious award for his seminal discoveries in protein-folding mechanics, including developing therapies for severe neurodegenerative and cardiovascular diseases.

Investigational, clinical-stage antidepressant MAP4343 shown to reduce alcohol intake in a mouse model of alcoholism.

The three winning teams receive grants to support highly innovative research focused on transforming catalysis, biological imaging, and our understanding of interorgan communication.

Flexible compounds made with Nobel-winning click chemistry can be used in energy-storing capacitors at high temperatures and electric fields.

In partnership with Cue Health, the study will deploy at-home COVID-19 tests, on-demand telemedicine and delivery of antiviral medication in an effort to lessen severe disease outcomes.

A noted biochemist, Walsh had an enormous impact on academic research, drug discovery and the biopharmaceutical field.

2022 year-end roundup: Clinical success and consistent funding validate Calibr’s pioneering approach to drug discovery.

Orexin-receptor antagonist suvorexant (Belsomra®) reduced alcohol intake and blocked relapse in preclinical tests.

A Scripps Research team discovered that a genetic lung disease can be fixed without correcting the mutated gene sequence—by controlling the way the corresponding protein folds to restore function.

Scripps Research and MIT scientists find that a modified immune protein harming brain connections is much more common in the brains of women with Alzheimer’s, compared to men.

By revealing how the structure of the PI3Kα protein changes in cancer cells, Scripps Research scientists point toward ways to target it with drugs.

Family of compounds known as 1,2,3,5-tetrazines could have wide application in making new pharmaceuticals, chemical and biological probes, and other products.

Scripps Research, IAVI, Fred Hutch, VRC and other collaborators publish study data in Science, helping validate novel vaccination strategy.

In a Scripps Research study, a nanoparticle treatment ‘cured’ mice that had a genetic arthritis condition.

A Scripps Research team showed how drugs can reduce alcohol preference in animal models of post-traumatic stress disorder.

Thirteen scientists were named to Clarivate’s Highly Cited Researchers list: a methodology for identifying the most influential researchers from around the world.  

A Scripps Research team developed a new tool that can predict how Parkinson’s disease patients will fare over the course of a year based on their genetics, brain scans and physical examinations. 

Finding uncovers a key property needed for CELMoD drugs, a type of protein degrader, to work effectively.

The five-year grant will support the development and distribution of innovative computational tools for advanced drug discovery.