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Chi-Huey Wong.
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Scripps Research professor Chi-Huey Wong to receive ACS Alfred Bader Award

Dissociation of the four-part TTR protein. The energy landscape shows stable states toward the bottom and unstable transition states toward the top. In the canonical pathway (red), the tetramer (T) dissociates via a native-like, compact transition state (‡1) into transient dimer intermediates (D) before full dissociation into monomers (M). In the newly discovered alternative pathway (blue), the tetramer dissociates through a more expanded transition state (‡2) directly into monomers. Credit: Jan-Hannes Schäfer, Scripps Research
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Scientists discover a new way that a disease-linked protein comes apart

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  • Surprising Brain Change Appears to Drive Alcohol Dependence
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    Surprising Brain Change Appears to Drive Alcohol Dependence

    A new study led by scientists at Scripps Research could help researchers develop personalized treatments for alcoholism and alcohol use disorder.

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    Scripps Florida Scientist Awarded $4.8 Million to Bring HIV Vaccine Closer to Human Trials

    The new funding will support a five-year project, led by Professor Michael Farzan, to bring a potential HIV vaccine closer to human clinical trials.

  • New Approach Makes Cells Resistant to HIV
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    New Approach Makes Cells Resistant to HIV

    "HIV is treatable but not curable—this remains a disease that causes a lot of suffering."

  • News

    TSRI Researchers Discover a Signal Driving Type 1 Diabetes

    "What we've done is get to the root cause of T1D, and this allowed us to use strategies to prevent diabetes."

  • News

    The Scripps Research Institute (TSRI) Expands New Board of Directors with the Appointment of Yucaipa Companies Founder and Philanthropist Ron Burkle

    Burkle is Founder and Chairman of the Ronald W. Burkle Foundation, whose mission is to positively influence people around the world and their communities.

  • News

    Experimental Small Molecule Shows Potential in Preventing Meth Relapse

    New research suggests that meth takes advantage of the brain’s natural learning process.

    Neuroscience Chitra Mandyam
  • A Molecular On/Off Switch for CRISPR
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    A Molecular On/Off Switch for CRISPR

    The researchers believe this new understanding of anti-CRISPR proteins may eventually lead to more sophisticated and efficient tools for gene editing.

  • TSRI Researchers Develop New Method to ‘Fingerprint’ HIV
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    TSRI Researchers Develop New Method to ‘Fingerprint’ HIV

    "The ability to identify the glycan fingerprint on HIV’s glycoprotein will help us develop a vaccine that matches what is found on the virus."

  • Philip Dawson Named Dean of The Scripps Research Institute’s Graduate Program
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    Philip Dawson Named Dean of The Scripps Research Institute’s Graduate Program

    Dawson brings to his new role more than 25 years’ experience at Scripps Research as a student, alumnus, faculty member and associate dean.

  • News

    Scientists Discover New Class of Anti-Diabetes Compounds that Reduce Liver Glucose Production

    Scientists may have found a new tool for studying—and maybe even treating—Type 2 diabetes, the form of diabetes considered responsible for close to 95 percent of cases in the United States.

  • News

    Researchers Discover Key to Drug Resistance in Common Breast Cancer Treatment

    Two immune system molecules may be key to the development of drug resistance in estrogen-driven breast cancers.

  • News

    Scripps Florida Scientists Develop New Drug Delivery Method for Cancer Therapy

    The new method involves a class of pharmaceuticals known as antibody-drug conjugates (ADCs), which include some of the most promising next-generation antibody therapeutics for cancer.

  • News

    Potential Drug Candidates Halt Prostate and Breast Cancer Growth

    Next, the researchers plan to further develop their molecule-screening strategy into a platform to test molecules against any form of RNA defect-related disease.

  • In the Battle for Real Estate, a Disordered Protein Wins Out
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    In the Battle for Real Estate, a Disordered Protein Wins Out

    "This work at the molecular level has a real potential to benefit patients."

  • News

    Fighting Blindness: TSRI Scientists Bring a Key Protein into Focus

    Scientists from the Florida campus of The Scripps Research Institute (TSRI) have discovered how a protein called α2δ4 establishes proper vision.

  • New Enzyme-Like Tool Lets Chemists Modify Hard-to-Reach Spots on Drug Molecules
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    New Enzyme-Like Tool Lets Chemists Modify Hard-to-Reach Spots on Drug Molecules

    Chemists at Scripps Research have devised a versatile molecule-building tool for creating new drugs and other chemical products.

  • News

    TSRI Researchers Find Standard Pacemakers and Defibrillators Safe for MRI Using a New Protocol

    "Given the great clinical demand for MRI for patients with a standard pacemaker or defibrillator, we wanted to determine the risk."

  • News

    TSRI-Invented Compound Ozanimod Shows Positive Results in Late-Stage Clinical Trial for Relapsing Multiple Sclerosis

    Results from a new Phase 3 study conducted by the Celgene Corporation demonstrate that ozanimod, a drug candidate originally discovered and optimized at Scripps Research, can reduce the frequency of multiple sclerosis relapse.

  • News

    The Scripps Research Institute Announces New Board Members and Chairman of the Board

    Scripps Research, one of the world's largest, private, non-profit research organizations, today announced the appointment of nine new members to its Board of Directors.

  • News

    Scripps Florida Scientists Take Aim at Obesity-Linked Protein

    Is there a way to get metabolism to ramp up—even when it’s not cold out?

  • News

    Scripps Florida Collaboration Awarded $3.3 Million to Develop Next-Generation Breast Cancer Therapies

    "At Scripps Florida we not only do great science, but we have even greater opportunities to collaborate on projects like this."

  • TSRI Researchers Discover How the Brain Turns Chronic Stress into Pathological Anxiety
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    TSRI Researchers Discover How the Brain Turns Chronic Stress into Pathological Anxiety

    A Scripps Research team has described the role of two important molecules in the brain that work together to trigger intense anxiety.

    Translational Medicine Behavioral Science
  • News

    Scripps Florida Scientists Find Clue to Why Zika, But Not Its Close Relatives, Causes Birth Defects

  • News

    TSRI Chemists Unveil Versatile New Method for Making Chiral Drug Molecules

    "This method essentially mimics the ability of the enzymes in our cells to turn simple organic molecules into chiral molecules."

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