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  Fentanyl makeover: Core structural redesign could lead to safer pain medications

  Modified molecule shows diminished respiratory depression—the leading cause of opioid overdose deaths—while retaining full pain-blocking capability.

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  How “invisible” vaccine scaffolding boosts HIV immune response

  Scripps Research scientists designed a DNA scaffold that carries HIV vaccine proteins into the body and sharpens the immune response against the virus.

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  Scientists measure cellular membrane thickness inside cells for the first time

  Measuring membrane thickness was previously only possible in artificial membranes—now scientists can do it inside intact cells, providing crucial context for understanding how cells work.

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  Scripps Research study links sleep variability with sleep apnea and hypertension

  How consumers’ digital activity trackers could enable personalized health screening and early intervention for cardiovascular health and beyond.

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  Study uncovers disrupted brain balance in alcohol dependence

  Experiments show how dependence on alcohol rewires the brain's "go" and "stop drinking" signaling systems, with implications for preventing relapse.

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  New technique lights up where drugs go in the body, cell by cell

  Scripps Research scientists developed a technique that maps drug binding in individual cells throughout the body, potentially explaining side effects and guiding safer drug development.

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  A jolt to the system: Scripps Research biophysicists uncover new electrical transmission in cells

  “Tiny biological batteries” can change the cell membrane’s electrical properties—a discovery that has big implications for health, as many essential cellular processes hinge upon precise electrical activity.

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  Study reveals a key hormonal circuit in the kidneys

  Scripps Research scientists identify the protein that helps kidney cells regulate renin, providing foundational insight into how kidneys function.

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  Nanoparticle vaccine strategy could protect against Ebola and other deadly filoviruses

  Scripps Research scientists turn nanoparticles into virus “showcases” to help the immune system recognize deadly threats.

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  Study reveals high stakes of early immune development—and a potential probiotic fix

  Scripps Research scientists find that certain gut bacteria are essential for building immune defenses during infancy, pointing to new strategies for protecting children’s health.