Darrell Irvine, PhD
Professor
Department of Immunology and Microbiology
Lita Annenberg Hazen Chair; Professor and Vice-Chair, Department of Immunology & Microbiology
Research Focus
The Irvine Lab aims to collaborate across immunology, microbiology and other areas to engage with translational science opportunities, particularly around infectious disease and cancer. A major effort of Dr. Irvine's laboratory at Scripps will be directed toward vaccine development for HIV and cancer immunotherapy.
Engineering strategies directed toward problems in cellular immunology can lead to treatments for cancer, infectious diseases and autoimmune conditions. The Irvine lab aims to achieve this by integrating principles from immunology with biotechnology and materials chemistry. Specifically, Dr. Irvine applies engineering principles to modulate and empower the immune system in the prevention and treatment of human diseases. For example, his lab is developing synthetic materials (smart materials and nanotechnology) to enhance vaccines against infectious disease and cancer, as well as materials that can help improve anti-tumor immune responses.
Select Publications
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Guenaga, Javier; Ádori, Monika; Bale, Shridhar; Phulera, Swastik; Zygouras, Ioannis; Schleich, Fabian-Alexande A.; Castro Dopico, Xaquin; Agrawal, Sashank; Ota, Miyo; Wilson, Richard; Cluff, Jocelyn; Dzvelaia, Tamar; Mandolesi, Marco; Lee, Wen-Hsi H.; Walsh, Agnes A.; Melo, Mariane B.; Verkoczy, Laurent; Irvine, Darrell J.; Corcoran, Martin; Wilson, Ian A.; Carnathan, Diane; Silvestri, Guido; Ward, Andrew B.; Ozorowski, Gabriel; Karlsson Hedestam, Gunilla B.; Wyatt, Richard T. Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex. 2026.
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Ghosh, Amrit Ra R.; Habib, Rumi; Mishra, Nitesh; Roark, Ryan S.; Akauliya, Madhav; Albowaidey, Ali A.; Allen, Joel D.; Amereh, Khaled; Avillion, Gabriel; Bottermann, Maria; Liang, Bo; Chaudhary, Namit; Callaghan, Sean; Dye, Jonathan; Li, Xuduo; Ellis-Pugh, Jordan R.; Roy Chowdhury, Rohan; James, Nicole E.; Liu, Xiaotie; Maiorino, Laura; Villavicencio, Paula M.; Nedellec, Rebecca; Oberoi, Prabhgun; Sowers, Kirsten J.; Park, Younghoon; Prum, Thavaleak; Rodriguez, Linette; Ssozi, Maria; Torres, Jonathan L.; Walsh, Agnes A.; Warner, John E.; Weldon, Stephanie R.; Xu, Liling; Wiehe, Kevin; Crispin, Max; Ward, Andrew B.; Nair, Usha; Hahn, Beatrice H.; Burton, Dennis R.; Shapiro, Lawrence; Kwong, Peter D.; Irvine, Darrell J.; Andrabi, Raiees; Shaw, George M.; Batista, Facundo D. Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization. 2026, 11, eadz5064.
