Chi-Huey Wong, PhD
Professor
Department of Chemistry
Scripps Family Chair Professor
Research Focus
Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Our current interests are centered on developing new methods to understand the role of glycosylation in protein structure and function, as well as in cancer progression, bacterial and viral infections, neurodegenerative disorders, and immune responses. Programmable one-pot and chemo-enzymatic methods for the synthesis of oligosaccharides and glycoproteins, glycan microarrays, glycosylation probes, and glycoengineered proteins like antibodies are being developed to study glycosylation in biology, disease progression, and drug discovery. Our goal is to identify novel targets associated with carbohydrate recognition to develop next-generation medicines. This includes low-sugar vaccines against cancer and microbial infections, glycoengineered antibodies with improved efficacy and control of glyco-immune checkpoints, and inhibitors of key enzymes involved in the biosynthesis of disease-associated glycans. Overall, by decoding complex glycosylation and building comprehensive wet-lab datasets, we are developing AI-driven, next-generation medicines.
Select Publications
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Lo, Jennifer M.; Wong, Chi-Huey Decoding Protein Glycosylation for Better Vaccine and Antibody Development. Accounts of Chemical Research 2026, 59, 501-517.
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Li, R; Krasnova, L.; Wong, C.- H. Expedient Assembly of Multi-antennary N-glycans from Common N-Glycan Cores with Orthogonal Protection for the Profiling of Glycan-binding Proteins. Journal of the American Chemical Society 2025, 147, 12937-12948 .
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Huang, Han-Wen; Wong, Chi-Huey Cell-based glycoengineering for production of homogeneous and specific glycoform-enriched antibodies with improved effector functions. Proceeding of the National Academy of Sciences 2025, 122:e2423853122.
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Wang, S.- W.; Lin, K.- Y.; Wong, Chi-Huey Mechanism of antigen presentation and specificity of antibody cross-reactivity elicited by an oligosaccharide-conjugate cancer vaccine. Journal of the American Chemical Society 2023, 145, 9840-9849 .
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Huang, H.- Y.; Ma, C.; Lin, K.- Y.; Wong, C.- H. Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models. Science Translational Medicine 2022, 14, eabm0899.
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Lin, Chih-Wei; Chen, Ming-Wei; Wong, Chi-Huey Homogeneous antibody and CAR-T cells with improved effector functions targeting SSEA-4 glycan on pancreatic cancer. Proceedings of the National Academy of Sciences 2021, 118 (50):e2114774118.
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