Chi-Huey Wong, PhD

Scripps Family Chair Professor
Professor of Chemistry
Department of Chemistry
California Campus


 Email

Scripps Research Joint Appointments

The Skaggs Institute for Chemical Biology
Faculty, Graduate Program

Other Joint Appointments

Academia Sinica, Taipei, Taiwan

Research Focus

Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Current interest is centered on the development of discovery tools for understanding the role of biological glycosylation in cancer progression, bacterial and viral infection, neurodegenerative disorder and immune response. Programmable one-pot synthesis as well as chemo-enzymatic synthesis of oligosaccharides and homogeneous glycoproteins, and design of glycan microarrays and glycosylation probes are among the tools being developed for the study of cell-surface glycoconjugates. The ultimate goal of our research is to identify novel glycan targets for therapeutic development, including the development of carbohydrate-based vaccines, homogeneous antibodies with optimized effector functions, and inhibitors of key enzymes involved in the biosynthesis of glycan targets.

Our main focus is to develop new tools for understanding the role of biological glycosylation in the development of diseases with an ultimate goal of developing new therapeutic strategies to combat them.


Education

Ph.D. (Organic Chemistry), Massachusetts Institute of Technology, 1982
M.S. (Biochemical Sciences), National Taiwan University, 1977
B.S. (Chemistry & Biochemical Sciences), National Taiwan University, 1970

Professional Experience

2006-2019 Professor of Chemistry, Chemistry, Scripps Research
2006-2016 President, Academia Sinica
1996-2006 Member, The Skaggs Institute for Chemical Biology, Scripps Research
1989-2006 Ernest W. Hahn Professor of Chemistry, Chemistry, Scripps Research
1989-2006 Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences, Scripps Research
1991-1999 Head, Frontier Research Program on Glycotechnology, RIKEN: Institute of Physical and Chemical Research
1987-1989 Professor of Chemistry, Texas A&M University
1987-1989 Professor, Department of Biochemistry and Biophysics and the Institute of Biosciences and Technology, Texas A&M University
1986-1987 Associate Professor of Chemistry, Texas A&M University
1983-1986 Assistant Professor of Chemistry, Texas A&M University
1982-1983 Postdoctoral Fellow with G.M. Whitesides, Harvard University

Awards & Professional Activities

Searle Scholar Award in Biomedical Sciences, 1985; Presidential Young Investigator in Chemistry, 1986; ACS Arthur C. Cope Scholar Award, 1993; The IUPAC International Carbohydrate Award, 1994; Elected Member of Academia Sinica, Taipei 1994; Elected Member of the American Academy of Arts and Sciences, 1996; The ACS Harrison Howe Award in Chemistry, 1998; The ACS Claude S. Hudson Award in Carbohydrate Chemistry, 1999; The International Enzyme Engineering Award, 1999; Presidential Green Chemistry Award, 2000; Elected member of the National Academy of Sciences, 2002; The ACS Award for Creative Work in Synthetic Organic Chemistry, 2006; Humboldt Research Award for Senior Scientists, 2008; F. A. Cotton Medal for Excellence in Chemical Research, 2005;  The ACS Arthur C. Cope Award, 2012; The Wolf Prize in Chemistry, 2014; The Royal Society of Chemistry Robert Robinson Award, 2015.

Selected References

All Publications

Koeller, K., Wong, C.-H., "Enzymes for chemical synthesis," Nature, 2001, 409, 232-240.

Sears, P., Wong, C.-H., "Toward automated synthesis of oligosaccharides and glycoproteins," Science, 2001, 291, 2344-2350.

Shie, J.-J., Liu, Y.-C., Lee, Y.-M., Lim, C., Fang, J.-M., Wong, C.-H., “An azido-BODIPY probe for glycosylation: initiation of strong fluorescence upon triazole formation”, J. Am. Chem. Soc., 2014, 136, 9953-9961.

Lin, C.-W. et al., “A common glycan structure on immunoglobulin G for enhancement of effector functions”, Proc. Nat. Acad. Sci. U.S.A., 2015, 112, 10611-10616.

Danishefsky, S.J., Shue, Y.-K., Chang, M.N., Wong, C.-H., "Development of Globo-H Cancer Vaccine," Acc. Chem. Res., 2015, 48, 643-652.

Shivatare, S.S. et al., "Modular Synthesis of N-glycans and Arrays for the Hetero-ligand Binding Analysis of Antibodies," Nature Chem., 2016, 8, 338-346.

Krasnova, L.  and Wong, C.-H., “Understanding the chemistry and biology of glycosylation with glycan synthesis”, Annual Review of Biochemistry, 2016, 85, 599-630.

Kizuka, Y. et al., “High sensitivity and low toxicity fucose probe for glycan imaging and biomarker discovery”, Cell Chem. Biol., 2016, 23, 782-792.

Huang, Y.-W. et al., “Residues comprising the enhanced aromatic sequon influence protein N-glycosylation efficiency”, J. Am. Chem. Soc., 2017, 139, 12947-12955.

Tseng, T.-H. et al., “Substrate preference and interplay of fucosyltransferase 8 and N-acetylglucosaminyltransferases”, J. Am. Chem. Soc., 2017, 139, 9431-9434.

Liu, C.-P. Shivatare, V. S., Wu, C.-Y., Wong, C.-H., “Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation”, Proc. Nat. Acad. Sci. U.S.A., 2018, 115, 720-725.

Wu, W.-S., Cheng, W.-C., Cheng, T.-R., Wong, C.-H., “Affinity-based screen for inhibitors of bacterial transglycosylase”,  J. Am. Chem. Soc., 2018, 140, 2752-2755.

Shivatare, V. S. et al., “Unprecedented role of hybrid N-glycans as ligands for HIV-1 broadly neutralizing antibodies”, J. Am. Chem. Soc., 2018, 140, 5202-5210.

Lo, P.-W., Shie, J.-J., Chen, C.-H., Wu, C.-Y., Hsu, T.-L., Wong, C.-H., “O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2”, Proc. Nat. Acad. Sci. U.S.A., 2018, 115, 7302-7307.

Dey, S. and Wong, C.-H., “Programmable one-pot synthesis of heparin pentasaccharides enabling access to regiodefined sulfate derivatives”, Chem. Sci., 2018, 9, 6685-6691.

Cheng, C.-W. et al., “Hierarchical and programmable one-pot synthesis of oligosaccharides”, Nature Commun., 2018, 9, 5202.

Krasnova, L. and Wong, C.-H., “Oligosaccharide synthesis and translational innovation”, J. Am. Chem. Soc., 2019, 141, 3735-54.

Chuang, P.-K. et al., “Functional study and signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer”, Proc. Nat. Acad. Sci. U.S.A., 2019, 116, 3518-23.

Tseng, Y.-C. et al., “Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections”, Proc. Nat. Acad. Sci. U.S.A., 2019, 116, 4200-05.

Lo, H.-J. et al., “Synthesis of sialidase-resistant oligosaccharide and antibody glycoform containing α2,6-linked 3Fax-Neu5Ac”, J. Am. Chem. Soc., 2019, 141, 6484-6488.


Links

The Skaggs Institute for Chemical Biology

Molecules Caught in the Act-- Scientists at TSRI Solve Elusive Enzyme Mechanism

The Skaggs Institute Scientific Report

Antivirals, Anti-Cancers, and Antibiotics in One Pot