Anne Hanneken, MD

Associate Professor of Translational Medicine

Department of Translational Medicine

Research Focus

The focus of our macular degeneration research program is on improving the function of the cells that support the chemistry of vision, the rod and cone photoreceptors. With a unique multidisciplinary team of ophthalmologists, computational chemists, cell biologists and biochemists, we are using advanced computer modeling technology to design a treatment that will protect visual pigments in the photoreceptor cells and improve visual function. The focus of the research is to identify a treatment that will stabilize the delicate opsin proteins that activate the visual transduction cascade (a series of biochemical steps that are responsible for vision in all vertebrate species).

Education

Professional Experience

Awards & Professional Activities

Select Publications

Abbas, Fatima; Becker, Silke; Jones, Bryan W.; Mure, Ludovic S.; Panda, Satchidananda; Hanneken, Anne; Vinberg, Frans Revival of light signalling in the postmortem mouse and human retina. 2022, 606, 351-357.
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Hanneken, Anne; Mercado, Maluz; Maher, Pamela Constitutive and Regulated Shedding of Soluble FGF Receptors Releases Biologically Active Inhibitors of FGF-2.. International Journal of Molecular Sciences 2021, 22, 2712.
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Mure, Ludovic S.; Vinberg, Frans; Hanneken, Anne; Panda, Satchidananda Functional diversity of human intrinsically photosensitive retinal ganglion cells.. Science (New York, N.Y.) 2019, 366, 1251-1255.
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Hanneken, Anne; Neikirk, Thomas; Johnson, Jennifer; Kono, Masahiro Biochemical Measurements of Free Opsin in Macular Degeneration Eyes: Examining the 11-CIS Retinal Deficiency Hypothesis of Delayed Dark Adaptation (An American Ophthalmological Society Thesis).. Transactions of the American Ophthalmological Society 2017, 115, T1.
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Anderson, D. M.; Ablonczy, Z.; Koutalos, Y.; Hanneken, Anne M.; Spraggins, J. M.; Calcutt, M. W.; Crouch, R. K.; Caprioli, R. M.; Schey, K. L. Bis(monoacylglycero) phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas. Scientific Reports 2017, 7, 17352.
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Adler, L.; Boyer, N. P.; Anderson, D. M.; Spraggins, J. M.; Schey, K. L.; Hanneken, Anne M.; Ablonczy, Z.; Crouch, R. K.; Koutalos, Y. Determination of N-retinylidene-N-retinylethanolamine (A2E) levels in central and peripheral areas of human retinal pigment epithelium. Photochemical & Photobiological Sciences 2015, 14, 1983-1990.
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Magazine

Professor Anne Hanneken honored by the Medical College of Wisconsin with 2024 Alumna of the Year Award

The Medical College of Wisconsin bestowed its 2024 Alumna of the Year Award to Anne Hanneken, MD, an associate professor in the Department of Molecular Medicine at Scripps Research.

Awards & Honors

News

Scripps Research and UC San Diego join national team to make vision-restoring whole eye transplants a reality

Technologies developed by both teams will map the human eye-brain connectome, extend the lifespan of the revived human eye, and help regenerate and monitor the optic nerve after a whole eye transplant.

Translational Medicine

Magazine

A conversation with Anne Hanneken, MD

The retina is an extension of the central nervous system, and so far, nearly impossible to transplant or regenerate. But Associate Professor Anne Hanneken, MD, is working to change that.

Translational Medicine

News

Light after death: scientists revive human eyes

By restoring the light-sensing function of human retinas hours after death, Scripps Research and collaborators reveal a new way to study age-related macular degeneration and other eye disorders.

Translational Medicine