Renan V.H. de Carvalho, PhD
Assistant Professor
Department of Immunology and Microbiology
Research Focus
The Laboratory of Immune Longevity (LIL) focuses on uncovering the drivers of long-lived immune responses. Our research spans a range of interests, but our top priority is understanding plasma cell longevity and the determinants of durable humoral immunity. Using transgenic mouse models alongside infection and immunization strategies, we aim to identify the mechanisms that lead to successful, long-lived immunity - and why such outcomes often fail to be accomplished.
Select Publications
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Barbulescu, Alexandru; Bilanovic, Jana; Langelaar, Tom; Teetz, A Katharin K.; Urnavicius, Linas; Hobbs, Alvaro; Shen, Jin-Ji J.; Abrahamse, Nadine H.; de Carvalho, Renan V H; Mesin, Luka; Ferreira, Cecilio L.; Bortolatto, Juliana; Victora, Gabriel D. Antibody-mediated feedback modulates interclonal competition in the germinal center. Immunity 2026, 59, 734-745.e5.
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Zhang, Fengwen; Jenkins, Jesse; de Carvalho, Renan V H; Nakandakari-Higa, Sandra; Chen, Teresia; Abernathy, Morgan E.; Baharani, Viren A.; Nyakatura, Elisabeth K.; Andrew, David; Lebedeva, Irina V.; Lorenz, Ivo C.; Hoffmann, H-Heinric H.; Rice, Charles M.; Victora, Gabriel D.; Barnes, Christopher O.; Hatziioannou, Theodora; Bieniasz, Paul D. Pan-sarbecovirus prophylaxis with human anti-ACE2 monoclonal antibodies. Nature Microbiology 2023, 8, 1051-1063.
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de Carvalho, Renan V H; Ersching, Jonatan; Barbulescu, Alexandru; Hobbs, Alvaro; Castro, Tiago B R; Mesin, Luka; Jacobsen, Johanne T.; Phillips, Brooke K.; Hoffmann, Hans-Heinric H.; Parsa, Roham; Canesso, Maria Cecilia C; Nowosad, Carla R.; Feng, Allan; Leist, Sarah R.; Baric, Ralph S.; Yang, Emily; Utz, P J.; Victora, Gabriel D. Clonal replacement sustains long-lived germinal centers primed by respiratory viruses. Cell 2023, 186, 131-146.e13.
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de Carvalho, Renan V H; Lima-Junior, Djalma S.; da Silva, Marcus Vinícius G; Dilucca, Marisa; Rodrigues, Tamara S.; Horta, Catarina V.; Silva, Alexandre L N; da Silva, Patrick F.; Frantz, Fabiani G.; Lorenzon, Lucas B.; Souza, Marcos Miche M.; Almeida, Fausto; Cantanhêde, Lilian M.; Ferreira, Ricardo de Godoi M; Cruz, Angela K.; Zamboni, Dario S. Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition. Nature Communications 2019, 10, 5273.
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de Carvalho, Renan V H; Andrade, Warrison A.; Lima-Junior, Djalma S.; Dilucca, Marisa; de Oliveira, Caroline V.; Wang, Kun; Nogueira, Paula M.; Rugani, Jeronimo N.; Soares, Rodrigo P.; Beverley, Stephen M.; Shao, Feng; Zamboni, Dario S. Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome. Cell Reports 2019, 26, 429-437.e5.
