Frederick Barrett: Psychoactive compounds to treat depression, addiction & inflammation

In a special year-end episode of Science Changing Life, we’re revisiting five moments from 2025 that continue to shape how we think about science. Featuring insights from Scripps Research experts across genetics, infectious disease, public health surveillance and chronic illness, this episode features some of this year’s most memorable soundbites.

The data is clear: inflammatory bowel diseases like ulcerative colitis and Crohn’s are on the rise worldwide. In this episode, we sit down with Dr. Amy Lightner—VP of Clinical Development at Calibr-Skaggs and colorectal surgeon at Scripps Clinic—to explore what drives these diseases, an upcoming phase 2 clinical trial for a new regenerative medicine, and how she balances life between the operating room and the research lab.

This year on Science Changing Life, we’ve had some amazing scientists join us to share their work, their stories and what drives them. There’s one question we love to ask our guests: What advice would you give to scientists just starting out? We compiled their refreshingly honest answers into one episode—hear what they had to say.

Depression and alcohol dependence are often seen as personal struggles—but decades of study by Scripps Research professor Cindy Ehlers reveal a much bigger picture. In this episode of Science Changing Life, Ehlers breaks down how biology, culture and trauma interact to shape mental health outcomes. Learn how her work is paving the way for more effective interventions, and how new strategies—like culturally grounded prevention programs and digital tools—can reduce harm in high-risk communities.