Meng Zhang, PhD
Assistant Professor
Department of Molecular and Cellular Biology
Research Focus
The Zhang lab studies how cells organize, interact, and maintain homeostasis within their native environments, and how these dynamics are altered in aging and diseases using a combination of cutting-edge imaging technologies and sophisticated computational tools. We develop and apply spatial multi-omics tools for high-resolution, genomic-scale cell profiling in situ, charting cellular states and interactions across space and time. Our long-term goal is to leverage these insights to advance molecular understanding in biology, driving progress in precision medicine, disease intervention, and cell-based therapies.
Projects for new lab members:
- Understanding how single-cell molecular landscapes and cell-cell interactions change in aging and brain tumors using spatial multi-omics.
- Developing imaging-based methods for high-throughput proteome and metabolome profiling.
- Developing machine learning approaches to bridge live-cell imaging and genomic-scale molecular profiling in tissues.
Select Publications
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Zhang, Meng; Pan, X; Jung, W; Halpern, A; Eichhorn, S. W; Lei, Z; Cohen, L; Smith, K. A; Tasic, B; Yao, Z; Zeng, H; Zhuang, X Molecularly defined and spatially resolved cell atlas of the whole mouse brain.. Nature 2023, 624, 343-354.
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Yao, Z; van Valthoven, C.T. J.; Kunst, M; Zhang, Meng; McMillen, D A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain.. Nature 2023, 624, 317-332 .
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Fang, R; Xia, C; Close, J. L.; Zhang, Meng; He, J; Huang, Z; Halpern, A. R.; Long, B; Miller, J. A.; Lein, E. S.; Zhuang, X Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH.. Science 2022, 377, 56-62 .
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Zhang, Meng; Eichhorn, S. W.; Zingg, B; Yao, Z; Cotter, K; Zeng, H; Dong, H; Zhuang, X Spatially resolved cell atlas of the mouse primary motor cortex by MERFISH.. Nature 2021, 598, 137–143 .
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BRAIN Initiative Cell Census Network (BICCN). A multimodal cell census and atlas of the mammalian primary motor cortex.. Nature 2021, 598, 86–102.
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Zhang, Meng; Wang, L; Shu, S; Sancar, A; Zhong, D Bifurcating electron-transfer pathways in DNA photolyases determine the repair quantum yield.. Science 2016, 354, 209-213.
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