Sunnie M. Yoh, PhD - Scripps Research

Research Focus

My research focuses on studying disease mechanisms at the molecular level. My research is centered around innate immune pathways and their implications in autoimmunity, cancer and viral infection. One of my primary interests lies in unraveling the intricate ways in which innate immune surveillance operates on amyloidosis- a pathological hall mark of neurodegenerative disease (ND). My focus extends to understand detection of amyloids and a feedback loop between amyloidosis and neuroinflammation, a pivotal driver of NDs and develop a small molecule targeting immune surveillance machinery to break the loop.

In addition, my research endeavors aim to harness the therapeutic potential of small molecule modulators of innate immune pathways, particularly as vaccine adjuvants and in the realm of cancer immunotherapy. Employing a combination of system-based and mechanistic approaches, I delve into the intricate regulators of innate immune pathways to identify small molecule targets with promising therapeutic potential for a spectrum of immune-based diseases and treatment.

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Pohl, Marie O.; Martin-Sancho, Laura; Ratnayake, Ranjala; White, Kris M.; Riva, Laura; Chen, Qi-Yin; Lieber, Gauthier; Busnadiego, Idoia; Yin, Xin; Lin, Samuel; Pu, Yuan; Pache, Lars; Rosales, Romel; Déjosez, Marion; Qin, Yiren; Jesus, Paul D.; Beall, Anne; Yoh, Sunnie M.; Hale, Benjamin G.; Zwaka, Thomas P.; Matsunaga, Naoko; Garcı́a-Sastre, Adolfo; Stertz, Silke; Chanda, Sumit K.; Luesch, Hendrik Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity. 2022.
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Yin, Xin; Riva, Laura; Pu, Yuan; Martin-Sancho, Laura; Kanamune, Jun; Yamamoto, Yuki; Sakai, Kouji; Gotoh, Shimpei; Miorin, Lisa; Jesus, Paul D.; Yang, Ching‐Chieh; Herbert, Kristina M.; Yoh, Sunnie M.; Hultquist, Judd F.; Garcı́a-Sastre, Adolfo; Chanda, Sumit K. MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells. Cell Rep 2021.
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Yoh, Sunnie M.; Schneider, Monika; Seifried, Janna; Soonthornvacharin, Stephen; Akleh, Rana E.; Olivieri, Kevin; Jesus, Paul D.; Ruan, Chunhai; Castro, E. d.; Ruiz, Pedro A.; Germanaud, David; Portes, Vincent D.; Garcı́a-Sastre, Adolfo; König, Renate; Chanda, Sumit K. PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1. 2015.
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Jain, Prashant; Boso, Guney; Langer, Simon; Soonthornvacharin, Stephen; Jesus, Paul D.; Nguyen, Quy T.; Olivieri, Kevin; Portillo, Alex J.; Yoh, Sunnie M.; Pache, Lars; Chanda, Sumit K. Large-Scale Arrayed Analysis of Protein Degradation Reveals Cellular Targets for HIV-1 Vpu. 2018.
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Lin, Benjamin C.; Hong, Suk H.; Krig, Sheryl R.; Yoh, Sunnie M.; Privalsky, Martin L. A Conformational Switch in Nuclear Hormone Receptors Is Involved in Coupling Hormone Binding to Corepressor Release. 1997.
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