Skip to main content

Kurt Wuthrich, PhD

Professor

Department of Integrative Structural and Computational Biology

Cecil H. and Ida M. Green Professor of Structural Biology

Kurt Wuthrich, PhD

Research Focus

For 50 years, Wuthrich groups at the ETH Zurich, Zurich, Switzerland, at Scripps Research, La Jolla, CA, USA and at the iHuman Institute of ShanghaiTech University, Shanghai, China have worked on nuclear magnetic resonance spectroscopy (NMR) with biological macromolecules. Contributions include the method for macromolecular structure determination with NMR in solution and the use of the principles of transverse relaxation-optimized spectroscopy (TROSY) for NMR experiments with large supramolecular assemblies. Applications over the years were focused on differentiation in higher organisms, immune suppression and neuropathology. As of April 2019, research using NMR techniques is continued at ShanghaiTech University, with a focus on trans-membrane signal transfer by G protein-coupled receptors (GPCRs). At Scripps Research and the ETH Zurich, projects on the general theme 'healthcare in the ageing human societies of the 21st century' are pursued, mainly considering the impact of sarcopenia on the human healthspan.

Select Publications


  • Wuthrich, Kurt NMR studies of structure and function of biological macromolecules (Nobel lecture). Angewandte Chemie-International Edition 2003, 42, 3340-3363.

    View
  • Zhang, Jinfeng; Feng, Dandan; Cheng, Jianjun; Wüthrich, Kurt Adenosine A Receptor (AAR) Ligand Screening Using the F-NMR Probe FPPA. 2023, 145, 15061-15064.

    View
  • Pan, Benxun; Liu, Dongsheng; Yang, Lingyun; Wüthrich, Kurt GPCR large-amplitude dynamics by F-NMR of aprepitant bound to the neurokinin 1 receptor. 2022, 119, e2122682119.

  • Wuthrich, Kurt Brownian motion, spin diffusion and protein structure determination in solution.. Journal of magnetic resonance (San Diego, Calif. : 1997) 2021, 107031.

  • Shimada, I.; Ueda, T.; Kofuku, Y.; Eddy, M. T.; Wuthrich, Kurt GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures. Nature Reviews Drug Discovery 2019, 18, 59-82.

    View
  • Susac, Lukas; Eddy, M. T.; Didenko, T.; Stevens, Raymond C.; Wuthrich, Kurt A2A adenosine receptor functional states characterized by 19F-NMR. Proceedings of the National Academy of Sciences of the United States of America 2018, 115, 12733-12738.

    View
Groundbreaking Science.
Life-changing Medicine.