Bruno Melillo, PhD

Select Publications

• Goetzke, F Wieland; Bernard, Steffen M.; Ju, Cheng-We W.; Pollock, Jonathan; DeMeester, Kristen E.; Gross, Jacob; Simon, Gabriel M.; He, Chuan; Melillo, Bruno; Cravatt, Benjamin F. Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5. Nature Chemical Biology 2026, 22, 770-782.

  View

• Liu, Zhonglin; Remsberg, Jarrett R.; Li, Haoxin; Njomen, Evert; DeMeester, Kristen E.; Tao, Yongfeng; Xia, Guoqin; Hayward, Rachel E.; Yoo, Minjin; Nguyen, Tracey; Simon, Gabriel M.; Schreiber, Stuart L.; Melillo, Bruno; Cravatt, Benjamin F. Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders. Journal of the American Chemical Society 2024, 146, 10393-10406.

  View

• Njomen, Evert; Hayward, Rachel E.; DeMeester, Kristen E.; Ogasawara, Daisuke; Dix, Melissa M.; Nguyen, Tracey; Ashby, Paige; Simon, Gabriel M.; Schreiber, Stuart L.; Melillo, Bruno; Cravatt, Benjamin F. Multi-tiered chemical proteomic maps of tryptoline acrylamide-protein interactions in cancer cells. Nature Chemistry 2024, 16, 1592-1604.

  View

• Ogasawara, Daisuke; Konrad, David B.; Tan, Zher Yi Y.; Carey, Kimberly L.; Luo, Jessica; Won, Sang Joo J.; Li, Haoxin; Carter, Trever R.; DeMeester, Kristen E.; Njomen, Evert; Schreiber, Stuart L.; Xavier, Ramnik J.; Melillo, Bruno; Cravatt, Benjamin F. Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes. Cell Chemical Biology 2024, 31, 2138-2155.e32.

  View

• Won, Sang Joo J.; Zhang, Yuxiang; Reinhardt, Christopher J.; Hargis, Lauren M.; MacRae, Nicole S.; DeMeester, Kristen E.; Njomen, Evert; Remsberg, Jarrett R.; Melillo, Bruno; Cravatt, Benjamin F.; Erb, Michael A. Redirecting the pioneering function of FOXA1 with covalent small molecules. Molecular Cell 2024, 84, 4125-4141.e10.

  View