Joseph Kissil, PhD

A hallmark of cancer cells is that they lack contact inhibition, even when crowded. A new study from Kissil lab reveals a protein biologists thought they knew well, YAP, is playing an unexpected role in switching off that normal, healthy response, with input from many players.

"Until now, most of the research to screen for cancer drugs has used cells that are growing flat on a plate."

"Clearly, there is an urgent need to develop better options for these patients."

“Since this is a major pathway for diseases like cancer and fibrosis, our findings add a brand-new layer of valuable information."