Michael McHeyzer-Williams, PhD

Regulating adaptive immunity to enhance memory. Helper T cells are the master regulators of adaptive immunity that control the development of antigen-specific B cell immunity. Our research focuses on the cellular and molecular mechanisms controlling follicular helper T cell regulated development of antigen-specific B memory. Recent findings from our laboratory use high-order multidimensional single cell strategies to analyze B cell memory at antigen recall. These studies provide new insight into the cellular organization and molecular control of adaptive immunity that are central to long-term immune protection and have implications for contemporary vaccine design.