Ludovic Autin, PhD
Institute Investigator
Department of Integrative Structural and Computational Biology
Research Focus
Our work focus to fill the gaps existing between scientific visualization and artistic illustration leading to better understanding and a better view of some highly complex scientific data: such as induced-fit molecular recognition, viral unit self-assembly, the complex mechanism of DNA structure, and crowded cellular environments. We are developing software frameworks dedicated to multiscale molecular modeling and visualization: ePMV (protein visualization in third party 3D software), cellPACK (crowded cellular molecular modeling), cellPACKgpu (real time crowded cellular modeling), mesoscale ( web interface for integrating data ), cellPAINT ( illustration and interaction with molecular landscape) and cellPAINT-VR (modeling and interacting with biological structure in a Virtual Reality context).
HIV tour from the mesoscale explorer :
Mycoplasma Genitalium model :
CellPAINT:
PhD Paris 5 University September 2002 - September 2005
“Structural study of the tenase and the prothrombinase systems”,
Director: Bruno Villoutreix Paris 5 University – INSERM U648, Paris, France.
During his thesis work, Ludovic was the first to produce accurate atomic models of key large protein complexes involved in the blood coagulation pathway, the pro-coagulant Factor VIIIa-FXa and the prothrombinase complexes. The formation of these complexes is an essential event in the procoagulant reaction that leads to clot formation, but the exact understanding of these interactions wasn’t known at the time of his thesis. His work in protein-protein docking, the methods that predict at the atomic level how two proteins can bind, led to a better characterization of atomic interactions involved in this complex assembly. His 3D representations of these protein complexes allowed a better understanding of diseases such as hemophilia and thrombosis at the molecular level. In that work, he combined different approaches (homology modeling, protein-protein docking, loop modeling) to help understand the complex mechanisms of molecular biological systems.
Select Publications
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Rose, Alexander; Sehnal, David; Goodsell, David S.; Autin, Ludovic Mesoscale explorer: Visual exploration of large-scale molecular models. Protein science : a publication of the Protein Society 2024, 33, e5177.
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Autin, Ludovic; Goodsell, David S.; Viola, Ivan; Olson, Arthur CellVis2: a conference on visualizing the molecular cell. Trends in biochemical sciences 2024, 49, 559-563.
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Autin, Ludovic; Barbaro, Brett A.; Jewett, Andrew I.; Ekman, Axel; Verma, Shruti; Olson, Arthur J.; Goodsell, David S. Integrative structural modelling and visualisation of a cellular organelle. QRB discovery 2022, 3, e11.
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Maritan, Martina; Autin, Ludovic; Karr, Jonathan; Covert, Markus W.; Olson, Arthur J.; Goodsell, David S. Building Structural Models of a Whole Mycoplasma Cell. Journal of molecular biology 2022, 434, 167351.